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公开(公告)号：EP1819708A2
公开(公告)日：2007-08-22
申请号：EP05849039.2
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which can be used in the treatment of respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, diseases of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions which contain said compounds.
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公开(公告)号：EP1819708B1
公开(公告)日：2012-01-11
申请号：EP05849039.2
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which can be used in the treatment of respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, diseases of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions which contain said compounds.
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3.发明公开SUBSTITUIERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ]NDLICHEN ERKRANKUNGEN 审中-公开取代的蝶啶FOR KEYSTONE]农村疾病治疗
公开(公告)号：EP1828189A1
公开(公告)日：2007-09-05
申请号：EP05813409.9
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P11/06
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines, which are suitable for treating respiratory tract or gastro-intestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system, or carcinomas. The invention also relates to pharmaceutical compositions containing said compounds.
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4.发明授权
公开(公告)号：EP2649052B1
公开(公告)日：2014-10-22
申请号：EP11796671.3
申请日：2011-12-09
发明人： PRIEPKE, Henning , KUELZER, Raimund , MACK, Juergen , PFAU, Roland , STENKAMP, Dirk , PELCMAN, Benjamin , ROENN, Robert , LUBRIKS, Dimitrijs , SUNA, Edgars
IPC分类号： C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/4184 , A61P29/00
CPC分类号： C07D403/04 , C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
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公开(公告)号：EP2539323B3
公开(公告)日：2017-10-04
申请号：EP11705858.6
申请日：2011-02-21
发明人： HAUEL, Norbert , CECI, Angelo , DOODS, Henri , KONETZKI, Ingo , MACK, Juergen , PRIEPKE, Henning , SCHULER-METZ, Annette , WALTER, Rainer , WIEDENMAYER, Dieter
IPC分类号： C07D211/62 , C07D213/81 , C07D233/90 , C07D239/28 , C07D261/18 , C07D271/10 , C07D239/557 , C07D207/277 , C07C237/24 , A61K31/165 , A61K31/44 , A61K31/505 , A61K31/506 , C07D401/12 , C07D405/12
CPC分类号： C07D401/12 , C07D405/12
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公开(公告)号：EP2401256B1
公开(公告)日：2013-04-17
申请号：EP10711628.7
申请日：2010-02-23
发明人： HAUEL, Norbert , CECI, Angelo , DOODS, Henri , KONETZKI, Ingo , MACK, Juergen , PRIEPKE, Henning , SCHULER-METZ, Annette , WALTER, Rainer , WIEDENMAYER, Dieter
IPC分类号： C07D211/62 , C07D213/81 , C07D233/90 , C07D239/28 , C07D261/18 , C07D271/10 , C07D239/557 , C07D207/277 , C07D237/24 , A61K31/165 , A61K31/44 , A61K31/505 , A61K31/506 , C07D401/12 , C07D405/12
CPC分类号： C07D405/12 , C07C237/24 , C07C2601/02 , C07D207/277 , C07D211/62 , C07D213/81 , C07D233/90 , C07D239/28 , C07D239/557 , C07D261/18 , C07D271/10 , C07D401/12
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7.发明公开SUBSTITUIERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ]NDLICHEN ERKRANKUNGEN 审中-公开SUTITANTERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ] NDLICHEN ERKRANKUNGEN
公开(公告)号：EP1824854A2
公开(公告)日：2007-08-29
申请号：EP05823962.5
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, disease of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions containing said compounds.
摘要翻译： 本发明涉及适用于治疗呼吸或胃肠疾病，关节，皮肤或眼睛炎性疾病，外周或中枢神经系统疾病或癌症的新型蝶啶。 本发明还涉及含有所述化合物的药物组合物。
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公开(公告)号：EP2403852B1
公开(公告)日：2014-10-29
申请号：EP10706659.9
申请日：2010-03-05
发明人： PFAU, Roland , ARNDT, Kirsten , DOODS, Henri , KLINDER, Klaus , KUELZER, Raimund , LUBRIKS, Dimitrijs , MACK, Juergen , PELCMAN, Benjamin , PRIEPKE, Henning , ROENN, Robert , STENKAMP, Dirk , SUNA, Edgars
IPC分类号： C07D235/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D403/12
CPC分类号： C07D235/30 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
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公开(公告)号：EP2032585B1
公开(公告)日：2014-07-23
申请号：EP07765267.5
申请日：2007-05-15
发明人： DOLLINGER, Horst , MARTYRES, Domnic , MACK, Juergen , GOEGGEL, Rolf , JUNG, Birgit , NICKOLAUS, Peter
IPC分类号： C07D519/00 , C07D475/08 , A61K31/519 , A61K31/55 , A61P35/00
CPC分类号： C07D475/08 , C07D519/00
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10.发明公开
公开(公告)号：EP2649052A1
公开(公告)日：2013-10-16
申请号：EP11796671.3
申请日：2011-12-09
发明人： PRIEPKE, Henning , KUELZER, Raimund , MACK, Juergen , PFAU, Roland , STENKAMP, Dirk , PELCMAN, Benjamin , ROENN, Robert , LUBRIKS, Dimitrijs , SUNA, Edgars
IPC分类号： C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/4184 , A61P29/00
CPC分类号： C07D403/04 , C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of formula (I), their use as inhibitors of the microsomal prostaglandin E
2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the 10 treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R
1 , R
2 , R
3 , R
4 , R
6 , R
2 ,R
7 , R
8 , R
9 , R
a , R
b have meanings given in the description.
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