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公开(公告)号：EP0337430A2
公开(公告)日：1989-10-18
申请号：EP89106518.7
申请日：1989-04-12
发明人： Hofstead, Sandra June , Matson, James Andrew , Lam, Kin Sing , Forenza, Salvatore , Bush, James Allen , Tomita, Koji
摘要： Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. The antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues. Kedarcidin has the following sequence:
摘要翻译： Kedarcidin是由链孢菌属（Streptoalloteichus sp。）生产的蛋白质抗肿瘤抗生素。 十一月 菌株L585-6，ATCC 53650.抗生素包含非蛋白发色团和具有114个氨基酸残基的单链多肽。 Kedarcidin具有以下顺序：
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公开(公告)号：EP0337430B1
公开(公告)日：1994-02-16
申请号：EP89106518.7
申请日：1989-04-12
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公开(公告)号：EP0450327B1
公开(公告)日：1996-06-05
申请号：EP91103316.5
申请日：1991-03-05
发明人： Lam, Kin Sing , Schroeder, Daniel R. , Mattei, Jacqueline , Forenza, Salvatore , Matson, James A.
CPC分类号： C07H19/044 , C12P19/28
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4.发明公开Biosynthesis of rebeccamycin analogs by tryptophan analogs feeding 失效Rebeccamycinanaloga - Biosynthese durchZuführungvon Tryptophananalogen。
公开(公告)号：EP0450327A1
公开(公告)日：1991-10-09
申请号：EP91103316.5
申请日：1991-03-05
发明人： Lam, Kin Sing , Schroeder, Daniel R. , Mattei, Jacqueline , Forenza, Salvatore , Matson, James A.
CPC分类号： C07H19/044 , C12P19/28
摘要： Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.
摘要翻译： 在发酵过程中，某些色氨酸类似物在重新克雷霉素生产菌株的发酵过程中向培养基中加入，导致产生具有有利抗肿瘤性质的新的雷贝卡霉素类似物。
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5.发明公开Rebeccamycin analog and pharmaceutical composition containing it 失效Rebeccamycinanalog和pharmazeutisches Mittel，das esenthält。
公开(公告)号：EP0445736A1
公开(公告)日：1991-09-11
申请号：EP91103317.3
申请日：1991-03-05
发明人： Lam, Kin Sing , Schroeder, Daniel R. , Mattei, Jaqueline Marie , Matson, James Andrew , Forenza, Salvatore
IPC分类号： C07H19/044 , A61K31/70 , C12P19/28
CPC分类号： C07H19/044 , C12P19/28
摘要： Addition of bromine to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of a new rebeccamycin derivative (1) having advantageous antineoplastic properties.
摘要翻译： 在克雷霉素生产菌株的发酵过程中向培养基中加入溴导致产生具有有利抗肿瘤性质的新的雷贝卡霉素衍生物（1）。
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公开(公告)号：EP0337430A3
公开(公告)日：1991-07-24
申请号：EP89106518.7
申请日：1989-04-12
发明人： Hofstead, Sandra June , Matson, James Andrew , Lam, Kin Sing , Forenza, Salvatore , Bush, James Allen , Tomita, Koji
摘要： Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. The antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues. Kedarcidin has the following sequence:
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