专利检索 ap:("Bristol-Myers Squibb Company" OR "Roche Innovation Center Copenhagen A/S") AND inv:"CACACE, Angela, M." 第 1 页

1.

发明公开
ANTISENSE OLIGONUCLEOTIDES TARGETING ALPHA-SYNUCLEIN AND USES THEREOF 审中-公开

公开(公告)号：EP3737387A1

公开(公告)日：2020-11-18

申请号：EP19702763.4

申请日：2019-01-11

申请人： Bristol-Myers Squibb Company , Roche Innovation Center Copenhagen A/S

发明人： OLSON, Richard, E. , CACACE, Angela, M. , MEREDITH, Jere, E., JR. , DEVIDZE, Nino , LOY, James, K. , BALDICK, Carl, J. , PENDRI, Annapurna , MCDONALD, Ivar, M. , HAGEDORN, Peter , JENSEN, Marianne, Lerbech

IPC分类号： A61K31/712 , C12N15/113

2.

发明公开
ANTISENSE OLIGONUCLEOTIDES TARGETING ALPHA-SYNUCLEIN AND USES THEREOF 审中-公开

公开(公告)号：EP3737761A1

公开(公告)日：2020-11-18

申请号：EP19702766.7

申请日：2019-01-11

申请人： Bristol-Myers Squibb Company , Roche Innovation Center Copenhagen A/S

发明人： OLSON, Richard, E. , CACACE, Angela, M. , MEREDITH JR., Jere, E. , DEVIDZE, Nino , LOY, James, K. , BALDICK, Carl, J. , PENDRI, Annapurna , MCDONALD, Ivar, M. , HAGEDORN, Peter , JENSEN, Marianne, Lerbech

IPC分类号： C12N15/113 , C07K14/47

3.

发明公开
METHODS OF SELECTING THERAPEUTIC MOLECULES 审中-公开

公开(公告)号：EP3954993A1

公开(公告)日：2022-02-16

申请号：EP21186197.6

申请日：2016-02-04

申请人： Bristol-Myers Squibb Company , Roche Innovation Center Copenhagen A/S

发明人： OLSON, Richard E. , CACACE, Angela, M. , HAGEDORN, Peter , HØG, Anja Mølhart , NIELSEN, Niels, Fisker , LI, Dong , BROWN, Jeffrey, M. , MERCER, Stephen, E. , JENSEN, Marianne, Lerbech

IPC分类号： G01N33/50

摘要： The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.

4.

发明公开
METHODS OF SELECTING THERAPEUTIC MOLECULES 审中-公开
标题翻译：选择治疗分子的方法

公开(公告)号：EP3254104A1

公开(公告)日：2017-12-13

申请号：EP16709167.7

申请日：2016-02-04

申请人： Bristol-Myers Squibb Company , Roche Innovation Center Copenhagen A/S

发明人： OLSON, Richard E. , CACACE, Angela, M. , HAGEDORN, Peter , HØG, Anja Mølhart , NIELSEN, Niels, Fisker , LI, Dong , BROWN, Jeffrey, M. , MERCER, Stephen, E. , JENSEN, Marianne, Lerbech

IPC分类号： G01N33/50

CPC分类号： G01N33/5058 , G01N33/5014

摘要： The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.