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公开(公告)号：EP3737761A1
公开(公告)日：2020-11-18
申请号：EP19702766.7
申请日：2019-01-11
发明人： OLSON, Richard, E. , CACACE, Angela, M. , MEREDITH JR., Jere, E. , DEVIDZE, Nino , LOY, James, K. , BALDICK, Carl, J. , PENDRI, Annapurna , MCDONALD, Ivar, M. , HAGEDORN, Peter , JENSEN, Marianne, Lerbech
IPC分类号： C12N15/113 , C07K14/47
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公开(公告)号：EP3737387A1
公开(公告)日：2020-11-18
申请号：EP19702763.4
申请日：2019-01-11
发明人： OLSON, Richard, E. , CACACE, Angela, M. , MEREDITH, Jere, E., JR. , DEVIDZE, Nino , LOY, James, K. , BALDICK, Carl, J. , PENDRI, Annapurna , MCDONALD, Ivar, M. , HAGEDORN, Peter , JENSEN, Marianne, Lerbech
IPC分类号： A61K31/712 , C12N15/113
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公开(公告)号：EP4081513A1
公开(公告)日：2022-11-02
申请号：EP20845303.5
申请日：2020-12-22
发明人： CHUPAK, Louis, S. , OLSON, Richard, E. , VELAPARTHI, Upender , ZHENG, Xiaofan , GENTLES, Robert, G. , DING, Min , WARRIER, Jayakumar, Sankara
IPC分类号： C07D401/04 , A61K31/4709 , A61P35/00
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4.发明公开ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 审中-公开芳基和杂四氢-1,4-二氮杂及其用途，用于阻止去甲肾上腺素，多巴胺和血清素再摄取
公开(公告)号：EP2146722A1
公开(公告)日：2010-01-27
申请号：EP08780604.8
申请日：2008-05-08
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D243/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The aryl- and heteroaryl-substituted tetrahydrobenzo-l,4-diazepine derivative compounds of the present invention are represented by formulae 1(A-D) having the following structure: where the substituents X and R1 -R8 are as defined herein.
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5.发明公开QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权CHINUKLIDINE衍生物如α-7尼古丁乙酰胆碱受体配体
公开(公告)号：EP2493892A1
公开(公告)日：2012-09-05
申请号：EP09744572.0
申请日：2009-10-29
发明人： COOK II, James H. , MCDONALD, Ivar, M. , KING, Dalton , OLSON, Richard, E. , WANG, Nenghui , IWUAGWU, Christiana, I. , ZUSI, F.,Christopher , MACOR, John, E.
IPC分类号： C07D498/20 , A61K31/439 , A61P25/28
CPC分类号： C07D498/20
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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6.发明公开ARYLOXY-AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 审中-公开和芳氧杂 - 取代tetrahydrobenzazepines及其使用的去甲肾上腺素，多巴胺和血清素回收抑制
公开(公告)号：EP2146720A1
公开(公告)日：2010-01-27
申请号：EP08747852.5
申请日：2008-05-08
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D471/04 , C07D223/16 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepine derivative compounds of the present invention are represented by formulae (I) (A-E) having the following structure where the carbon atom designated * is in the R or S configuration and the substituents X and R1-R9 are as defined herein.
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7.发明公开ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 有权芳基和杂-tetrahydrobenzazepines并用它来恢复LOCKING去甲肾上腺素，多巴胺和血清素
公开(公告)号：EP1904069A2
公开(公告)日：2008-04-02
申请号：EP06787476.8
申请日：2006-07-17
发明人： MOLINO, Bruce, F. , LIU, Shuang , SAMBANDAM, Aruna , GUZZO, Peter, R. , HU, Min , ZHA, Congxiang , NACRO, Kassoum , MANNING, David, D. , ISHERWOOD, Matthew, L. , FLEMING, Kristen, N. , CUI, Wenge , OLSON, Richard, E.
IPC分类号： A61K31/55 , C07D487/02 , C07D403/02
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II) where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
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公开(公告)号：EP1904069B1
公开(公告)日：2018-06-13
申请号：EP06787476.8
申请日：2006-07-17
发明人： MOLINO, Bruce, F. , LIU, Shuang , SAMBANDAM, Aruna , GUZZO, Peter, R. , HU, Min , ZHA, Congxiang , NACRO, Kassoum , MANNING, David, D. , ISHERWOOD, Matthew, L. , FLEMING, Kristen, N. , CUI, Wenge , OLSON, Richard, E.
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
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9.发明授权
公开(公告)号：EP2271650B1
公开(公告)日：2015-09-16
申请号：EP09733949.3
申请日：2009-04-20
发明人： COOK II, James, H. , MCDONALD, Ivar, M. , KING, Dalton , OLSON, Richard, E. , WANG, Nenghui , IWUAGWU, Christiana, I. , ZUSI, F., Christopher , MACOR, John, E.
IPC分类号： C07D498/20 , C07D519/00 , A61K31/439 , A61P25/28
CPC分类号： C07D498/20 , C07D519/00
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10.发明授权QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 有权CHINUKLIDINE衍生物如α-7尼古丁乙酰胆碱受体配体
公开(公告)号：EP2493892B1
公开(公告)日：2015-07-01
申请号：EP09744572.0
申请日：2009-10-29
发明人： COOK II, James H. , MCDONALD, Ivar, M. , KING, Dalton , OLSON, Richard, E. , WANG, Nenghui , IWUAGWU, Christiana, I. , ZUSI, F.,Christopher , MACOR, John, E.
IPC分类号： C07D498/20 , A61K31/439 , A61P25/28
CPC分类号： C07D498/20
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