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公开(公告)号：EP1839677B1
公开(公告)日：2010-12-15
申请号：EP05781799.1
申请日：2005-09-02
发明人： WANG, Zhibiao , LI, Faqi , XIAO, Ziwen , XIAO, Yanbing , LIU, Liping , WANG, Zhilong
IPC分类号： A61K49/22 , A61K9/127 , A61K31/685 , A61P35/00 , A61K41/00
CPC分类号： A61K41/0033 , A61K9/0009 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K31/685 , A61K49/226
摘要： An adjuvant of fluorocarbon emulsions for HIFU therapy, which can increase energy deposition in target regions during the therapy, comprises a discontinuous phase consisting of a core encapsuled by a film-forming material and a continuous phase consisting of aqueous medium, wherein the discontinuous phase is well distributed in the continuous one; the particle size of the discontinuous phase is 0.1-2µm; the amount of the film-forming material in the adjuvant is 0.1-100g/L; the core material used is a liquid which performs the liquid-gas phase transition at 38-100°C and is incorporated into the adjuvant in the amount of 5-200ml/L. The adjuvant of fluorocarbon emulsions for HIFU therapy is capable of upgrading the acoustic environment of target regions remarkably, increasing energy deposition in target tissues during HIFU therapy, and consequently significantly improving the damaging effect against tumor cells during clinical HIFU. And the usage of such adjuvant in HIFU therapy.
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2.发明公开A HIGH-INTENSITY FOCUSED ULTRASOUND PLASMID ADJUVANT AND ITS USE 审中-公开PLASMIDADJUVANZFÜRFOKUSSIERTEN ULTRASHALL HOHERINTENSITÄTUND DEREN VERWENDUNG
公开(公告)号：EP1847275A1
公开(公告)日：2007-10-24
申请号：EP05782127.4
申请日：2005-08-30
发明人： WANG, Zhibiao , LI, Faqi , LIU, Liping , XIAO, Yanbing , XIAO, Ziwen , WANG, Zhilong
CPC分类号： A61K33/10 , A61K31/575 , A61K31/66 , A61K33/42 , A61K41/0028 , A61K41/0052 , A61K45/06 , A61N7/02 , A61K2300/00
摘要： The present invention discloses a plasmid enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a nanometer-sized biocompatible solid. The present invention also discloses another plasmid enhancement agent for HIFU treatment, wherein, the enhancement agent comprises a discontinuous phase is comprised of a core material encapsulated by a membrane-forming material, and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and has a particle size ranging from 10-1000nm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; and the core material comprises nanometer-sized biocompatible solid selected from the group consisting of magnetic biomaterials, hydroxylapatite, and calcium carbonate, and the amount of the core material in the enhancement agent is 0.1-150g/L. The plasmid enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the effectiveness of clinical HIFU treatment to ablate the tumor cells can be significantly improved. Accordingly, the present invention discloses use of the above plasmid enhancement agent for HIFU treatment during HIFU treatment.
摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）处理的质粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括纳米尺寸的生物相容性固体。 本发明还公开了另一种用于HIFU处理的质粒增强剂，其中增强剂包括由膜形成材料包封的核心材料和由水性介质组成的连续相的不连续相; 不连续相均匀分散在连续相中，粒径范围为10-1000nm; 增强剂中的成膜材料的量为0.1-100g / L; 核心材料包括选自磁性生物材料，羟基磷灰石和碳酸钙的纳米尺寸的生物相容性固体，增强剂中的核心材料的量为0.1-150g / L。 用于本发明的HIFU处理的质粒增强剂可以显着改变目标位置的声学环境，并且可以在HIFU处理期间增加目标位置处的声能沉积。 最终可以显着改善临床HIFU治疗消融肿瘤细胞的功效。 因此，本发明公开了上述质粒增强剂在HIFU处理期间用于HIFU处理的用途。
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公开(公告)号：EP1842559A1
公开(公告)日：2007-10-10
申请号：EP05781870.0
申请日：2005-09-02
发明人： WANG, Zhibiao , LI, Faqi , XIAO, Yanbing , XIAO, Ziwen , LIU, Liping , WANG, Zhilong
IPC分类号： A61K49/00 , A61K49/22 , A61K9/127 , A61K31/685
CPC分类号： A61K41/0033 , A61K9/0019 , A61K9/107 , A61K9/127 , A61K31/685
摘要： The present invention discloses a particle enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprised of a core material encapsulated by a membrane-forming material and a continuous phase comprising of aqueous medium. The discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-8µm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; the core material is comprised of a liquid that does not undergo a liquid-gas phase transition at 38-100°C, and the amount of core material in the enhancement agent is 5-200g/L. The particle enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the ability of clinical HIFU treatment to ablate tumor cells can be significantly improved. Accordingly, the present invention discloses use of a particle enhancement agent for HIFU treatment during HIFU treatment.
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公开(公告)号：EP1842559B1
公开(公告)日：2010-08-25
申请号：EP05781870.0
申请日：2005-09-02
发明人： WANG, Zhibiao , LI, Faqi , XIAO, Yanbing , XIAO, Ziwen , LIU, Liping , WANG, Zhilong
IPC分类号： A61K41/00 , A61K9/127 , A61K31/685 , A61P35/00
CPC分类号： A61K41/0033 , A61K9/0019 , A61K9/107 , A61K9/127 , A61K31/685
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5.发明公开A HIGH-INTENSITY FOCUSED ULTRASOUND ADJUVANT AND THE SCREENING METHOD THEREOF 审中-公开FOKUSSIERTES HOCHINTENSITTSTS-ULTRASCHALLADJUVANS UND SCREENINGVERFAHRENDAFÜR
公开(公告)号：EP1842560A1
公开(公告)日：2007-10-10
申请号：EP05781912.0
申请日：2005-08-31
发明人： WANG, Zhilong , WANG, Zhibiao , LI, Faqi , XIAO, Yanbing , XIAO, Ziwen , LIU, Liping
CPC分类号： A61K41/0052 , A61K41/0028
摘要： The present invention discloses an enhancement agent for high intensity focused ultrasound (HIFU) treatment, which is administered to a patient before HIFU treatment and can reduce the level of EEF at the target location to be treated with HIFU. EEF is presented by the expression: EEF = ηPt / v (unit: J/mm 3 ), and refers to the HIFU energy needed to effectively treat a tumor per unit volume of the tumor, wherein, η=0.7; P refers to the total acoustic power of HIFU source (unit: W); t refers to the total time of HIFU treatment (unit: s); V refers to the volume of HIFU-induced lesions (unit: mm 3 ). If the amount of EEF at the target location before administration of the enhancement agent is defined as EEF (base) and the amount of EEF at the target location after administration of the enhancement agent is defined as EEF (measurement) , the ratio between EEF (base) and EEF (measurement) is more than 1, preferably more than 2, and more preferably over 4. The use of the enhancement agent for HIFU treatment of the present invention makes it possible to treat deep-seated tumors. In addition, patients with hepatic tumors can be effectively treated without removal of ribs. Accordingly, the present invention discloses methods for increasing acoustic energy deposition at target location during HIFU treatment and screening the enhancement agents for HIFU treatment.
摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）治疗的增强剂，其在HIFU治疗之前施用于患者，并且可以降低待HIFU治疗的目标位置处的EEF水平。 EEF由以下表达式表示：EEF =·Pt / v（单位：J / mm 3），并且是指每单位体积肿瘤有效治疗肿瘤所需的HIFU能量，其中，= 0.7; P指HIFU源的总声功率（单位：W）; t指HIFU治疗的总时间（单位：s）; V指HIFU诱导的病变体积（单位：mm 3）。 如果将增强剂施用前的目标位置处的EEF量定义为EEF（碱基），并且将施用增效剂后的目标位置处的EEF的量定义为EEF（测量值），则EEF 碱）和EEF（测量）大于1，优选大于2，更优选超过4.使用本发明的HIFU治疗用增强剂可以治疗深层肿瘤。 此外，可以有效地治疗肝肿瘤患者，而不需要排除肋骨。 因此，本发明公开了在HIFU处理期间增加目标位置处的声能沉积并筛选HIFU处理增强剂的方法。
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6.发明公开ADJUVANT OF FLUOROCARBON EMULSIONS FOR HIFU THERAPY AND THE USE THEREOF 有权ADJUVANS VON FLUOROCARBON-EMULSIONEN ZUR HIFU-THERAPIE UND VERWENDUNG DAVON
公开(公告)号：EP1839677A1
公开(公告)日：2007-10-03
申请号：EP05781799.1
申请日：2005-09-02
发明人： WANG, Zhibiao , LI, Faqi , XIAO, Ziwen , XIAO, Yanbing , LIU, Liping , WANG, Zhilong
IPC分类号： A61K49/00 , A61K49/22 , A61K9/127 , A61K31/685
CPC分类号： A61K41/0033 , A61K9/0009 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K31/685 , A61K49/226
摘要： The present invention discloses a fluoro-carbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-2µm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100°C, and the amount of the core material in the enhancement agent is 5-200ml/L. The fluoro-carbon emulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the ability of clinical HIFU treatment to ablate tumor cells can be significantly improved. Accordingly, the present invention discloses use of a fluoro-carbon emulsion enhancement agent for HIFU treatment during HIFU treatment.
摘要翻译： 本发明公开了一种用于HIFU处理的氟碳乳液增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括由膜形成材料包封的芯材料和由水性介质组成的连续相的不连续相; 不连续相均匀分散在连续相中，不连续相的粒径为0.1-2μm; 增强剂中的成膜材料的量为0.1-100g / L; 核心材料由在38-100℃下经历液相 - 气相转变的液体组成，增强剂中芯材的量为5-200ml / L。 本发明的用于HIFU处理的氟碳乳液增强剂可以显着改变目标位置的声学环境，并且可以在HIFU处理期间增加目标位置处的声能沉积。 最终，临床HIFU治疗消融肿瘤细胞的能力可以显着提高。 因此，本发明公开了在HIFU处理中使用氟碳乳液增强剂进行HIFU处理。
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