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公开(公告)号：EP1839677B1
公开(公告)日：2010-12-15
申请号：EP05781799.1
申请日：2005-09-02
发明人： WANG, Zhibiao , LI, Faqi , XIAO, Ziwen , XIAO, Yanbing , LIU, Liping , WANG, Zhilong
IPC分类号： A61K49/22 , A61K9/127 , A61K31/685 , A61P35/00 , A61K41/00
CPC分类号： A61K41/0033 , A61K9/0009 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K31/685 , A61K49/226
摘要： An adjuvant of fluorocarbon emulsions for HIFU therapy, which can increase energy deposition in target regions during the therapy, comprises a discontinuous phase consisting of a core encapsuled by a film-forming material and a continuous phase consisting of aqueous medium, wherein the discontinuous phase is well distributed in the continuous one; the particle size of the discontinuous phase is 0.1-2µm; the amount of the film-forming material in the adjuvant is 0.1-100g/L; the core material used is a liquid which performs the liquid-gas phase transition at 38-100°C and is incorporated into the adjuvant in the amount of 5-200ml/L. The adjuvant of fluorocarbon emulsions for HIFU therapy is capable of upgrading the acoustic environment of target regions remarkably, increasing energy deposition in target tissues during HIFU therapy, and consequently significantly improving the damaging effect against tumor cells during clinical HIFU. And the usage of such adjuvant in HIFU therapy.
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公开(公告)号：EP1847294B1
公开(公告)日：2009-10-14
申请号：EP05781862.7
申请日：2005-08-26
发明人： CHEN, Wenzhi , WEN, Yingang , Wang, Zhibao , WANG, Zhilong , LIN, Tao
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B90/14 , A61B2090/378
摘要： The invention relates to an ultrasound therapy system, and more particularly to a focused ultrasound therapy device, which uses an image alignment and fusion method to guide the therapy. The therapy system provided by the invention comprises central control means, ultrasound energy application means, moving and locating means for ultrasound energy application means, real-time B-type ultrasound image guiding means. Moreover, the inventive system also has patient's posture fixing means, with the aid of which a real-time B-type ultrasound image is aligned with a diagnostic image, and on the basis of the alignment the B-type ultrasound image and the diagnostic image are fused so as to guide the therapy. Compared to the known scheme in the art, the invention is effective and has low cost to resolve the high-intensity ultrasound focused therapy, and more particularly for the difficult tumor therapy problem it provides a very practical scheme, which can be easily used in clinical tumor therapies.
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3.发明公开APPARATUS FOR DELIVERY OF A MEDIA INTO A BODY CAVITY AND APPARATUS FOR BLOCKING ULTRASOUND 审中-公开装置适用于体内CAVE阻断超声波的介质的供应和设备
公开(公告)号：EP1854495A1
公开(公告)日：2007-11-14
申请号：EP05781828.8
申请日：2005-08-31
发明人： WANG, Zhilong , WANG, Zhibiao , BAI, Jin , XIONG, Zhengai
摘要： The present invention generally relates to a medical apparatus. More particularly, the present invention relates to an apparatus for delivering a medium to body cavity of mammals including a human, especially to an apparatus for expanding rectum. Specifically, the present invention relates to the field of focused ultrasound treatment with a main purpose to provide an auxiliary device for ultrasound therapy applied to uterine myoma so as to avoid damage by ultrasound after focused within body. Therefore, the present invention provides an apparatus for blocking ultrasound, comprising (1) lead-in means for entering into said body cavity; and (2) accommodation means for containing ultrasound blocking medium, which enwraps the lead-in means outside.
摘要翻译： 本发明基因的反弹涉及一种医疗装置。 更具体地，本发明涉及到用于一个介质输送到哺乳动物（包括人）的体腔，特别爱到用于扩大直肠。 具体而言，本发明涉及一种聚焦超声治疗领域具有主要目的是提供一种用于适用于子宫肌瘤超声治疗辅助装置，以便避免通过超声破坏聚焦体内之后。 因此，本发明提供了一种装置用于阻挡超声波，包括：（1）引入装置，用于输入到所述体腔内; 和（2），用于容纳含超声阻挡介质，其enwraps在导入外装置的装置。
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4.发明公开A HIGH-INTENSITY FOCUSED ULTRASOUND PLASMID ADJUVANT AND ITS USE 审中-公开PLASMIDADJUVANZFÜRFOKUSSIERTEN ULTRASHALL HOHERINTENSITÄTUND DEREN VERWENDUNG
公开(公告)号：EP1847275A1
公开(公告)日：2007-10-24
申请号：EP05782127.4
申请日：2005-08-30
发明人： WANG, Zhibiao , LI, Faqi , LIU, Liping , XIAO, Yanbing , XIAO, Ziwen , WANG, Zhilong
CPC分类号： A61K33/10 , A61K31/575 , A61K31/66 , A61K33/42 , A61K41/0028 , A61K41/0052 , A61K45/06 , A61N7/02 , A61K2300/00
摘要： The present invention discloses a plasmid enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a nanometer-sized biocompatible solid. The present invention also discloses another plasmid enhancement agent for HIFU treatment, wherein, the enhancement agent comprises a discontinuous phase is comprised of a core material encapsulated by a membrane-forming material, and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and has a particle size ranging from 10-1000nm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; and the core material comprises nanometer-sized biocompatible solid selected from the group consisting of magnetic biomaterials, hydroxylapatite, and calcium carbonate, and the amount of the core material in the enhancement agent is 0.1-150g/L. The plasmid enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the effectiveness of clinical HIFU treatment to ablate the tumor cells can be significantly improved. Accordingly, the present invention discloses use of the above plasmid enhancement agent for HIFU treatment during HIFU treatment.
摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）处理的质粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括纳米尺寸的生物相容性固体。 本发明还公开了另一种用于HIFU处理的质粒增强剂，其中增强剂包括由膜形成材料包封的核心材料和由水性介质组成的连续相的不连续相; 不连续相均匀分散在连续相中，粒径范围为10-1000nm; 增强剂中的成膜材料的量为0.1-100g / L; 核心材料包括选自磁性生物材料，羟基磷灰石和碳酸钙的纳米尺寸的生物相容性固体，增强剂中的核心材料的量为0.1-150g / L。 用于本发明的HIFU处理的质粒增强剂可以显着改变目标位置的声学环境，并且可以在HIFU处理期间增加目标位置处的声能沉积。 最终可以显着改善临床HIFU治疗消融肿瘤细胞的功效。 因此，本发明公开了上述质粒增强剂在HIFU处理期间用于HIFU处理的用途。
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公开(公告)号：EP1842559A1
公开(公告)日：2007-10-10
申请号：EP05781870.0
申请日：2005-09-02
发明人： WANG, Zhibiao , LI, Faqi , XIAO, Yanbing , XIAO, Ziwen , LIU, Liping , WANG, Zhilong
IPC分类号： A61K49/00 , A61K49/22 , A61K9/127 , A61K31/685
CPC分类号： A61K41/0033 , A61K9/0019 , A61K9/107 , A61K9/127 , A61K31/685
摘要： The present invention discloses a particle enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprised of a core material encapsulated by a membrane-forming material and a continuous phase comprising of aqueous medium. The discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-8µm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; the core material is comprised of a liquid that does not undergo a liquid-gas phase transition at 38-100°C, and the amount of core material in the enhancement agent is 5-200g/L. The particle enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the ability of clinical HIFU treatment to ablate tumor cells can be significantly improved. Accordingly, the present invention discloses use of a particle enhancement agent for HIFU treatment during HIFU treatment.
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公开(公告)号：EP1837051B1
公开(公告)日：2012-06-13
申请号：EP05771731.6
申请日：2005-08-02
发明人： CHEN, Wenzhi , WANG, Zhibiao , WANG, Zhilong , LIN, Tao , ZHAO, Chunliang
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B2090/378
摘要： The high intensity focused ultrasound therapeutic apparatus according to the invention comprises a ultrasonic transducer, an image sampling means, a drive unit for driving the'iultrasonic transducer and a movement mechanism for moving the ultrasonic transducer and the image sampling means. The high intensity focused ultrasound therapeutic apparatus further comprise a signal processing unit connected with the image sampling means, for accepting and saving the initial image from the target before the treatment is performed, and accepting and saving the image on a certain specific time during the high intensity focused ultrasound therapeutic process, and them estimating the treated effect based upon the before-treatment image and the after-treatment image, and a controller unit connected with the signal processing unit, the drive unit and the movement mechanism respectively controls the drive unit and the movement mechanism to stop the ultrasonic transducer if the signal processing unit determines that the expectant treatment effect have been obtained, and if the signal processing unit determines that the expectant treatment effect haven’t been obtained, controls the drive unit and the movement mechanism to go on.
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7.发明公开INTEGRAL TRANSDUCER APPARATUS FOR ULTRASONIC TREATMENT 审中-公开整合WANDLERGERÄTFÜRDIE ULTRASCHALLBEHANDLUNG
公开(公告)号：EP1837052A1
公开(公告)日：2007-09-26
申请号：EP05781872.6
申请日：2005-09-02
发明人： ZHOA, Chunliang , WANG, Zhibao , WANG, Zhilong , BAI, Jin
IPC分类号： A61N7/00
CPC分类号： A61N7/00
摘要： The present invention is to provide an integrated ultrasound therapy transducer. It includes a piezoelectric transducer to generate therapy ultrasound, a support to support the piezoelectric transducer, a power amplifying module to drive the piezoelectric transducer. Wherein both the power amplifying module and the piezoelectric transducer are installed within the enclosure of the therapy transducer. The advantages of the integrated ultrasound therapy transducer assembly of the present invention include minimizing ultrasound therapy equipment and to decrease its volume and weight; reducing the electromagnetic interference and radiation greatly; and realizing the consistent performances of the ultrasound therapy equipments in mass productions and making the ultrasound therapy equipments have interchangeability.
摘要翻译： 本发明是提供一种集成的超声治疗换能器。 它包括一个产生治疗超声波的压电换能器，支持压电换能器的支撑件，一个驱动压电换能器的功率放大模块。 其中功率放大模块和压电换能器都安装在治疗传感器的外壳内。 本发明的一体化超声治疗换能器组件的优点包括使超声治疗设备最小化并减小体积和重量; 大大降低电磁干扰和辐射; 实现超声波治疗设备在批量生产中的一致性，使超声治疗设备具有互换性。
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公开(公告)号：EP1466648A1
公开(公告)日：2004-10-13
申请号：EP02785032.0
申请日：2002-12-16
发明人： ZHAO, Chunliang , WANG, Zhibiao , WANG, Zhilong , YE, Fangwei
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B2017/00747
摘要： The invention provides an ultrasound therapeutic apparatus for treating skin lesions of human being, comprising a controlling device, an ultrasound transducer transmitting the therapeutic ultrasound beam to the subject, a focusing means. Said controlling device is the electrical control system of the ultrasound therapeutic apparatus. Said ultrasound transducer and said focusing means are placed in an ultrasound applicator, which can be held by hand. The ultrasound applicator, which can be held by hand, includes a handle and a housing forming a lumen and the said ultrasound transducer and said focusing means are placed in the said lumen. The ultrasound applicator can be held by clinicians' hand, performing a treatment on skin lesions of human being including the skin lesions of gynecology more conveniently.
摘要翻译： 本发明提供了一种用于治疗人的皮肤损伤的超声治疗装置，包括控制装置，将治疗性超声波束传送到对象的超声波换能器，聚焦装置。 所述控制装置是超声治疗仪的电气控制系统。 所述超声波换能器和所述聚焦装置被放置在可由手持的超声波施加器中。 可以手持的超声波施加器包括手柄和形成腔的壳体，并且所述超声换能器和所述聚焦装置放置在所述内腔中。 超声波治疗仪可以由临床医生掌握，更方便地对包括妇科皮肤病变在内的人体皮肤病变进行治疗。
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公开(公告)号：EP1842559B1
公开(公告)日：2010-08-25
申请号：EP05781870.0
申请日：2005-09-02
发明人： WANG, Zhibiao , LI, Faqi , XIAO, Yanbing , XIAO, Ziwen , LIU, Liping , WANG, Zhilong
IPC分类号： A61K41/00 , A61K9/127 , A61K31/685 , A61P35/00
CPC分类号： A61K41/0033 , A61K9/0019 , A61K9/107 , A61K9/127 , A61K31/685
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公开(公告)号：EP1847294A1
公开(公告)日：2007-10-24
申请号：EP05781862.7
申请日：2005-08-26
发明人： CHEN, Wenzhi , WEN, Yingang , Wang, Zhibao , WANG, Zhilong , LIN, Tao
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B90/14 , A61B2090/378
摘要： The present invention pertains to an ultrasound therapy system and more specifically, to a high-intensity focused ultrasound (HIFU) therapy apparatus guided by image registration and fusion method. The therapy system of the present invention comprises a central control means; an acoustic energy applicator; a mechanical driving and locating means of said acoustic energy applicator; a real-time B-mode ultrasound image guiding device. Further the therapy system of the present invention comprises an immobilization means for body position. By the help of this immobilization means for body position, real-time B-mode ultrasound images can be registered with diagnosis images, and then on the basis of registration, said B-mode ultrasound images are fused with said diagnosis images for guiding said therapy. Comparing to the existed technical solutions in this field, the present invention has effectively solved the difficult problems in high-intensity focused ultrasound therapy and particularly for tumor treatment with a low cost. And it provides a very practical technical solution, which can be easily applied to clinical treatment of tumors.
摘要翻译： 本发明涉及一种超声治疗系统，更具体地，涉及由图像配准和融合方法引导的高强度聚焦超声（HIFU）治疗装置。 本发明的治疗系统包括中央控制装置; 声能施加器; 所述声能施加器的机械驱动和定位装置; 实时B模式超声图像引导装置。 此外，本发明的治疗系统包括用于身体位置的固定装置。 借助于身体位置的这种固定装置，实时B模式超声图像可以与诊断图像一起登记，然后在注册的基础上，将所述B模式超声图像与用于引导所述治疗的所述诊断图像融合 。 与现有技术方案相比，本发明有效地解决了高强度聚焦超声治疗中的难题，特别是低成本肿瘤治疗。 它提供了一个非常实用的技术解决方案，可以很容易地应用于肿瘤的临床治疗。
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