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公开(公告)号：EP2510089B1
公开(公告)日：2015-10-21
申请号：EP10836590.9
申请日：2010-12-08
申请人： Codexis, Inc.
发明人： BONG, Yong Koy , CLAY, Michael, D. , COLLIER, Steven, J. , MIJTS, Benjamin , VOGEL, Michael , ZHANG, Xiyun , ZHU, Jun , NAZOR, Jovana , SMITH, Derek , SONG, Shiwei
CPC分类号： C12N9/0073 , C12N9/0083 , C12P17/165 , C12P17/182 , C12Y114/13022 , C12Y114/99 , Y02P20/52
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2.发明公开BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS 有权生物催化工艺基本上PRODUCING立体异构REINER，冷凝，双环脯氨酸
公开(公告)号：EP2307419A2
公开(公告)日：2011-04-13
申请号：EP09798485.0
申请日：2009-06-23
申请人： Codexis, Inc.
发明人： MIJTS, Benjamin , MULEY, Sheela , LIANG, Jack , NEWMAN, Lisa, M. , ZHANG, Xiyun , LALONDE, James , CLAY, Michael, D. , ZHU, Jun , GRUBER, John, M. , COLBECK, Jeffrey , MUNGER, John, D., Jr. , MAVINHALLI, Jagadeesh , SHELDON, Roger
IPC分类号： C07D487/04 , C07D487/02 , C07D403/12 , C07D403/02
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
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公开(公告)号：EP2649187A2
公开(公告)日：2013-10-16
申请号：EP11846568.1
申请日：2011-12-07
申请人： Codexis, Inc.
发明人： ANG, Ee Lui , CLAY, Michael, D. , BEHROUZIAN, Behnaz , EBERHARD, Ellen , COLLIER, Steven, J. , FU FAN, Jasyln , SMITH, Derek , SONG, Shiwei , ALVIZO, Oscar , WIDEGREN, Magnus , ZHU, Jun , XU, Junye , WILSON, Robert
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：EP2510089A2
公开(公告)日：2012-10-17
申请号：EP10836590.9
申请日：2010-12-08
申请人： Codexis, Inc.
发明人： BONG, Yong Koy , CLAY, Michael, D. , COLLIER, Steven, J. , MIJTS, Benjamin , VOGEL, Michael , ZHANG, Xiyun , ZHU, Jun , NAZOR, Jovana , SMITH, Derek , SONG, Shiwei
CPC分类号： C12N9/0073 , C12N9/0083 , C12P17/165 , C12P17/182 , C12Y114/13022 , C12Y114/99 , Y02P20/52
摘要： The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及用于制备prazole化合物的非天然存在的单加氧酶多肽，编码所述多肽的多核苷酸以及使用所述多肽的方法。
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公开(公告)号：EP2649187B1
公开(公告)日：2017-11-22
申请号：EP11846568.1
申请日：2011-12-07
申请人： Codexis, Inc.
发明人： ANG, Ee Lui , CLAY, Michael, D. , BEHROUZIAN, Behnaz , EBERHARD, Ellen , COLLIER, Steven, J. , FU FAN, Jasyln , SMITH, Derek , SONG, Shiwei , ALVIZO, Oscar , WIDEGREN, Magnus , ZHU, Jun , XU, Junye , WILSON, Robert
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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6.发明授权BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS 有权生物催化工艺基本上PRODUCING立体异构REINER，冷凝，双环脯氨酸
公开(公告)号：EP2307419B1
公开(公告)日：2013-11-06
申请号：EP09798485.0
申请日：2009-06-23
申请人： Codexis, Inc.
发明人： MIJTS, Benjamin , MULEY, Sheela , LIANG, Jack , NEWMAN, Lisa, M. , ZHANG, Xiyun , LALONDE, James , CLAY, Michael, D. , ZHU, Jun , GRUBER, John, M. , COLBECK, Jeffrey , MUNGER, John, D., Jr. , MAVINAHALLI, Jagadeesh , SHELDON, Roger
IPC分类号： C12P13/24 , C07D487/04 , C07D487/02 , C07D403/12 , C07D403/02
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
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