-
公开(公告)号：EP2483293B1
公开(公告)日：2016-11-30
申请号：EP10821066.7
申请日：2010-09-24
申请人： Codexis, Inc.
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
-
公开(公告)号：EP2649187B1
公开(公告)日：2017-11-22
申请号：EP11846568.1
申请日：2011-12-07
申请人： Codexis, Inc.
发明人： ANG, Ee Lui , CLAY, Michael, D. , BEHROUZIAN, Behnaz , EBERHARD, Ellen , COLLIER, Steven, J. , FU FAN, Jasyln , SMITH, Derek , SONG, Shiwei , ALVIZO, Oscar , WIDEGREN, Magnus , ZHU, Jun , XU, Junye , WILSON, Robert
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
-
公开(公告)号：EP3190123A1
公开(公告)日：2017-07-12
申请号：EP16201269.4
申请日：2010-09-24
申请人： Codexis, Inc.
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译： 提出了使用LovD酰基转移酶，具有酰基的硫酯和（i）硫醇清除剂和/或（ii）沉淀剂改善化学底物酰化的方法。 还提出了使用（i）活性炭作为硫醇清除剂和/或（ii）氢氧化铵作为沉淀剂生产辛伐他汀的改进方法。
-
公开(公告)号：EP2649187A2
公开(公告)日：2013-10-16
申请号：EP11846568.1
申请日：2011-12-07
申请人： Codexis, Inc.
发明人： ANG, Ee Lui , CLAY, Michael, D. , BEHROUZIAN, Behnaz , EBERHARD, Ellen , COLLIER, Steven, J. , FU FAN, Jasyln , SMITH, Derek , SONG, Shiwei , ALVIZO, Oscar , WIDEGREN, Magnus , ZHU, Jun , XU, Junye , WILSON, Robert
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
-
-
6.发明授权
公开(公告)号：EP2483292B1
公开(公告)日：2014-11-12
申请号：EP10821065.9
申请日：2010-09-24
申请人： Codexis, Inc.
发明人： GILSON, Lynne , COLLIER, Steven James , SUKUMARAN, Joly , YEO, Wan Lin , ALVISO, Oscar , TEO, Ee Ling , WILSON, Robert John , XU, Junye
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译： 本公开提供了可用于合成治疗重要的他汀类化合物的酰基转移酶。
-
7.发明公开IMPROVED LOV-D ACYLTRANSFERASE MEDIATED ACYLATION 有权VERBESSERTE DURCH LOV-D-ACYLTRANSFERASE VERMITTELTE ACYLIERUNG
公开(公告)号：EP2483293A1
公开(公告)日：2012-08-08
申请号：EP10821066.7
申请日：2010-09-24
申请人： Codexis, Inc.
IPC分类号： C07K14/00
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译： 本公开提供了可用于合成治疗重要的他汀类化合物的酰基转移酶。
-
公开(公告)号：EP2483292A1
公开(公告)日：2012-08-08
申请号：EP10821065.9
申请日：2010-09-24
申请人： Codexis, Inc.
发明人： GILSON, Lynne , COLLIER, Steven James , SUKUMARAN, Joly , YEO, Wan Lin , ALVISO, Oscar , TEO, Ee Ling , WILSON, Robert John , XU, Junye
IPC分类号： C07K14/00
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.014 秒)
