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    CD40 SPLICE VARIANTS, METHOD OF DETECTION THEREOF, COMPOSITIONS COMPRISING SAID VARIANT(S) OR NUCLEIC ACID ENCODING THE SAME AND USE THEREOF
    3.
    发明公开
    CD40 SPLICE VARIANTS, METHOD OF DETECTION THEREOF, COMPOSITIONS COMPRISING SAID VARIANT(S) OR NUCLEIC ACID ENCODING THE SAME AND USE THEREOF 审中-公开
    CD40剪接变体，方法OPTIONS检测，放在一起董先生包含选项或及其编码核酸及其用途

    公开(公告)号：EP1485480A2

    公开(公告)日：2004-12-15

    申请号：EP03702928.7

    申请日：2003-02-24

    申请人： Compugen Ltd.

    发明人： BERNSTEIN, Jeanne ,  MINTZ, Liat ,  ESHEL, Dani

    IPC分类号： C12N15/12

    CPC分类号： C07K16/2878 ,  A61K48/00 ,  C07K14/70578 ,  C12N2799/026

    摘要： Substantially pure CD40 splice variants which include unique tail sequences, fragments thereof comprising at least 10 amino acids including at least 4 amino acids of the unique tail sequence; the unique tail sequences, and homologues thereof having at least 10 amino acids and 90% identity and antibodies which bind to an epitope on such proteins are disclosed. Pharmaceutical composition comprising such protein, antibodies, isolated nucleic acid molecule that encode such proteins and pharmaceutical composition comprising such nucleic acid molecules are disclosed. The present invention relates to recombinant expression vectors which comprise such nucleic acid molecules and host cells which comprise such recombinant expression vectors are disclosed. In vitro methods of detecting in a sample the presence and/or quantity of such proteins or transcript which encodes such proteins are disclosed as are kits and reagents for performing the methods. Methods of modulating CD40-CD154 interactions in an individual are disclosed.

    NUCLEIC ACID AND AMINO ACID SEQUENCES OF A VEGF VARIANT
    5.
    发明公开
    NUCLEIC ACID AND AMINO ACID SEQUENCES OF A VEGF VARIANT 审中-公开
    甲VEGF变异的核酸和氨基酸序列

    公开(公告)号：EP1417310A2

    公开(公告)日：2004-05-12

    申请号：EP02741129.7

    申请日：2002-06-20

    申请人： Compugen Ltd.

    发明人： MINTZ, Liat ,  SAVITZKY, Kinneret ,  ENGEL, Sharon

    IPC分类号： C12N15/19

    CPC分类号： C07K14/52

    摘要： The invention concerns novel nucleic acid sequences and amino acid sequences of a novel variant of vascular endothelial growth factor (VEGF). The invention further concerns expression vectors and host cells containing said sequences as well as pharmaceutical compositions and detection methods using said sequences.