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公开(公告)号：EP2064234B1
公开(公告)日：2011-11-02
申请号：EP07875175.7
申请日：2007-09-18
申请人： Compugen Ltd.
发明人： COHEN, Yossi , SHEMESH, Ronen , TOPORIK, Amir , LEVINE, Zurit , WOOL, Assaf , DAHARY, Dvir , HECHT, Iris , BEIMAN, Merav , ROTMAN, Galit , AYALON-SOFFER, Michal
IPC分类号： C07K14/43
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
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2.发明公开VARIANTS OF HUMAN GLYCOPROTEIN HORMONE ALPHA CHAIN: COMPOSITIONS AND USES THEREOF 审中-公开人糖蛋白激素α链变异：组合和用途
公开(公告)号：EP1682576A1
公开(公告)日：2006-07-26
申请号：EP04799326.6
申请日：2004-11-07
申请人： Compugen Ltd. , Protalix Ltd.
发明人： SHEMESH, Ronen , BERNSTEIN, Jeanne , DAHARY, Dvir , SHALEV, Gil , BAUM, Gideon , SHAALTIEL, Yoseph
摘要： The present invention provides human glycoprotein hormone (hGPH) &-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino avid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the diagnosis, prevention and treatment of symptoms, diseases and disorders related to glycoprotein hormones.
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公开(公告)号：EP1721257A2
公开(公告)日：2006-11-15
申请号：EP05780004.7
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： COJOCARU, Gad, S. , POLLOCK, Sarah , LEVINE, Zurit , DIBER, Alexander , KOL, Guy , TOPORIK, Amir , SOREK, Rotem , DAHARY, Dvir , AYALON-SOFFER, Michal , AKIVA, Pinchas , NOVIK, Amit , COHEN, Yossi , SELLA-TAVOR, Osnat , WALACH, Shira , SAMEAH-GREENWALD, Shirley , SHEMESH, Ronen , SHKLAR, Maxim
IPC分类号： G06F15/16
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
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公开(公告)号：EP2167534B1
公开(公告)日：2012-07-04
申请号：EP08826161.5
申请日：2008-07-11
申请人： Compugen Ltd.
发明人： SHEMESH, Ronen , LEVINE, Zurit , TOPORIK, Amir , HERMESH, Chen , KLIGER, Yossef , GOFER, Eyal , WOOL, Assaf , DAHARY, Dvir , COHEN, Yossi
CPC分类号： C07K14/472 , A61K38/00 , C07K7/06 , C07K14/47 , C07K14/78 , C07K16/18 , C07K2317/34
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
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公开(公告)号：EP2167534A2
公开(公告)日：2010-03-31
申请号：EP08826161.5
申请日：2008-07-11
申请人： Compugen Ltd.
发明人： SHEMESH, Ronen , LEVINE, Zurit , TOPORIK, Amir , HERMESH, Chen , KLIGER, Yossi , GOFER, Eyal , WOOL, Assaf , DAHARY, Dvir , COHEN, Yossi
CPC分类号： C07K14/472 , A61K38/00 , C07K7/06 , C07K14/47 , C07K14/78 , C07K16/18 , C07K2317/34
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
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公开(公告)号：EP1713900A2
公开(公告)日：2006-10-25
申请号：EP05703149.4
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： DIBER, Alex , POLLOCK, Sarah , LEVINE, Zurit , NEMZER, Sergey , GREBINSKY, Vladimir , MELON, Brian , OLSON, Andrew , ROSENBERG, Avi , HAVIV, Ami , ZEVIN, Shaul , ZEKHARIA, Tomer , SHAKED, Zipi , OLSHANSKY, Moshe , FARKASH, Ariel , PRIVMAN, Eyal , NOVIK, Amit , KEREN, Naomi , COJOCARU, Gad, S. , AKIVA, Pinchas , SHEMESH, Ronen , SELLA-TAVOR, Osnat , MINTZ, Liat , XIE, Hanqing , DAHARY, Dvir , LEVANON, Erez , FREILICH, Shiri , BECK, Nili , ZHU, Wei-Yong , WASSERMAN, Alon , CHERMESH, Chen , AZAR, Idit , SOREK, Rotem , BERNSTEIN, Jeanne , COHEN, Yossi
IPC分类号： C12N1/00
CPC分类号： C07K14/705 , G06F19/20 , G06F19/22 , G06F19/28
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
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公开(公告)号：EP2064234A2
公开(公告)日：2009-06-03
申请号：EP07875175.7
申请日：2007-09-18
申请人： Compugen Ltd.
发明人： COHEN, Yossi , SHEMESH, Ronen , TOPORIK, Amir , LEVINE, Zurit , WOOL, Assaf , DAHARY, Dvir , HECHT, Iris , BEIMAN, Merav , ROTMAN, Galit , AYALON-SOFFER, Michal
IPC分类号： C07K14/43
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
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8.发明公开NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS OF COLON CANCER 审中-公开NEW核苷酸和氨基酸序列和试验和使用方法及其用于诊断结肠癌的
公开(公告)号：EP1749025A2
公开(公告)日：2007-02-07
申请号：EP05718397.2
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： SOREK, Rotem , AYALON-SOFFER, Michal , DAHARY, Dvir , NOVIK, Amit , TOPORIK, Amir , DIBER, Alexander , KOL, Guy , POLLOCK, Sarah , LEVINE, Zurit , COJOCARU, Gad, S. , SHEMESH, Ronen , COHEN, Yossi , SELLA-TAVOR, Osnat , SAMEAH-GREEN-WALD, Shirley , WALACH, Shira
IPC分类号： C07K14/435
CPC分类号： C12Q1/6886 , C12Q2600/112
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9.发明公开NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS 审中-公开NEW的核苷酸和氨基酸序列和它们在诊断试验和方法
公开(公告)号：EP1716256A2
公开(公告)日：2006-11-02
申请号：EP05805030.3
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： AYALON-SOFFER, Michal , POLLOCK, Sarah , SHEMESH, Ronen , SOREK, Rotem , ZURIT, Levine , SHAQED, Zipi , TOPORIK, Amir , COJOCARU, Gad, S. , DAHARY, Dvir , KOL, Guy , AKIVA, Pinchas , NOVIK, Amit , NEMZER, Sergey , DIBER, Alexander , SHKLAR, Maxim , SELLA-TAVOR, Osnat , BAZAK, Lily , FARKASH, Arial , COHEN, Yossi
CPC分类号： C07H21/04 , C07K14/47 , C12Q1/6883
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
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10.发明公开NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS OF CARDIAC DISEASE 审中-公开NEW核苷酸和FOR USE IN心脏病的诊断中的氨基酸序列和试验AND METHOD
公开(公告)号：EP1713827A2
公开(公告)日：2006-10-25
申请号：EP05726249.5
申请日：2005-01-27
申请人： Compugen Ltd.
发明人： COHEN, Yossi , DIBER, Alexander , TOPORIK, Amir , POLLOCK, Sarah , LEVINE, Zurit , AYALON-SOFFER, Michal , COJOCARU, Gad, S. , NOVIK, Amit , KOL, Guy , SELLA-TAVOR, Osnat , WALACH, Shira , SAMEAH-GREENWALD, Shirley , DAHARY, Dvir , SHEMESH, Ronen
CPC分类号： G01N33/6887 , G01N2800/32
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markets of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
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