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1.发明公开
公开(公告)号：EP1532238A2
公开(公告)日：2005-05-25
申请号：EP02778744.9
申请日：2002-11-05
申请人： Curagen Corporation
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHANT, John, S. , CHAPOVAL, Andrei , CHAUDHURI, Amitabha , EDINGER, Shlomit, R. , EISEN, Andrew , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GUO, Xiaojia , JI, Weizhen , KHRAMTSOV, Nikolai, V. , LEITE, Mario, W. , LI, Li , MEZES, Peter, S. , MILLET, Isabelle , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E.A. , RASTELLI, Luca , RIEGER, Daniel, K. , QUINN SENGER, Kerry, E. , SMITHSON, Glennda , SPADERNA, Steven, K. , SPYTEK, Kiberly, A. , STONE, David, J. , TWOMLOW, Nancy , VERNET, Corine, A.M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHIONG, Mei
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1638986A1
公开(公告)日：2006-03-29
申请号：EP02799178.5
申请日：2002-11-05
申请人： Curagen Corporation
发明人： AGEE, Michele, L. , ALSOBROOK, John, P. II , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine E. , CHANT, John S. , CHAUDHURI, Amitabha , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha, A. , GORMAN, Linda , GERLACH, Valerie, L. , JI, Weizhen , KEKUDA; Ramesh , KHRAMTSOV, Nikolai, V. , LI, Li , MALYANKAR, Uriel M. , MACDOUGALL, John, R. , MEZES, Peter, S. , MILLER, Charles, E. , MILLET, Isabelle , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , RASTELLI, Luca , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , TAUPIER, Raymond, J. Jr. , VERNET, Corine, A. M. , ZERHUSEN, Bryan, D. , ZHONG, Mel
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1549951A2
公开(公告)日：2005-07-06
申请号：EP03739026.7
申请日：2003-05-30
申请人： Curagen Corporation
发明人： ALVAREZ, Enrique , ANDERSON, David, W. , DHANABAL, Mohanraj , KHRAMTSOV, Nikolai, V. , LAROCHELLE, William, J. , LICHENSTEIN, Henri, S. , LI,Li , OOI, Chean, Eng , PADIGARU, Muralidhara , SHIMKETS, Richard, A. , ZHONG, Mei
CPC分类号： C07K14/4703 , A61K38/00
摘要： The proteins of the invention are a family used to modulate the activity of cells and their ability to attract blood vessels. The proteins are used to inhibit angiogenesis, inhibit cell migration, and inhibit actin filament formation. These proteins are used in this context to diagnose and treat proliferative disorders such as cancer.
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