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公开(公告)号：EP1638986A1
公开(公告)日：2006-03-29
申请号：EP02799178.5
申请日：2002-11-05
申请人： Curagen Corporation
发明人： AGEE, Michele, L. , ALSOBROOK, John, P. II , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine E. , CHANT, John S. , CHAUDHURI, Amitabha , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha, A. , GORMAN, Linda , GERLACH, Valerie, L. , JI, Weizhen , KEKUDA; Ramesh , KHRAMTSOV, Nikolai, V. , LI, Li , MALYANKAR, Uriel M. , MACDOUGALL, John, R. , MEZES, Peter, S. , MILLER, Charles, E. , MILLET, Isabelle , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , RASTELLI, Luca , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , TAUPIER, Raymond, J. Jr. , VERNET, Corine, A. M. , ZERHUSEN, Bryan, D. , ZHONG, Mel
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1572995A3
公开(公告)日：2005-12-14
申请号：EP02792183.2
申请日：2002-10-02
申请人： Curagen Corporation
发明人： SMITHSON, Glennda , MILLET, Isabelle , PEYMAN, John A. , KEKUDA, Ramesh , JU, Jingfang , LI, Li , GUO, Xiaojia , PATTURAJAN, Meera , SPYTEK, Kimberly A. , EDINGER, Shlomit R. , ELLERMAN, Karen , MALYANKAR, Uriel M. , ORT, Tatiana , GORMAN, Linda , ZERHUSEN, Bryan D. , ANDERSON, David W. , ZHONG, Mei , CATTERTON, Elina , JI, Weizhen , MILLER, Charles E. , RASTELLI, Luca , STONE, David J. , PENA, Carol E. A. , SHENOY, Suresh G. , SHIMKETS, Richard A. , ROTHENBERG, Mark E. , LEACH, Martin D. , AGEE, Michele L. , BERGHS, Constance , DIPIPPO, Vincent A. , EISEN, Andrew , GANGOLLI, Esha A. , RIEGER, Daniel K. , SPADERNA, Steven K.
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公开(公告)号：EP1578905A2
公开(公告)日：2005-09-28
申请号：EP02765778.2
申请日：2002-06-04
申请人： Curagen Corporation
发明人： AGEE, Michele L. , ANDERSON, David W. , BERGHS, Constance , CASMAN, Stacie J. , CATTERTON, Elina , DIPIPPO, Vincent A. , EDINGER, Shlomit R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha A. , GERLACH, Valerie L. , GORMAN, Linda , GUO, Xiaojia , HERRMANN, John L. , HJALT, Tord , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai V. , LI, Li , LIU, Xiaohong , MALYANKAR, Uriel M. , MILLER, Charles E. , MILLET, Isabelle , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol E.A. , RASTELLI, Luca , RIEGER, Daniel K. , ROTHENBERG, Mark E. , SHENOY, Suresh G. , SHIMKETS, Richard A. , SMITHSON, Glennda , SPADERNA, Steven K. , SPYTEK, Kimberly A. , STONE, David J. , VERNET, Corine A.M. , ZHONG, Haihong , ZHONG, Mei , ALSOBROOK, John P.,II , BURGESS, Catherine E. , LEPLEY, Denise M.
IPC分类号： C12N1/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
摘要翻译： 本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。 公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。
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公开(公告)号：EP1572948A2
公开(公告)日：2005-09-14
申请号：EP03754372.5
申请日：2003-06-04
申请人： Curagen Corporation
发明人： ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , EDINGER, Shlomit, R. , EISEN, Andrew , ELLERMAN, Karen , GERLACH, Valerie, L. , GORMAN, Linda , GUO, Xiaojia , GUSEV, Vladimir, Y. , JI, Weizhen , LI, Li , MACDOUGALL, John, R. , MALYANKAR, Uriel, M. , MILLET, Isabelle , ORT, Tatiana , PADIGARU, Muralidhara , PRAYAGA, Sudhirdas, K. , PATTURAJAN, Meera , PENA, Carol E.A. , PEYMAN, John A. , RIEGER, Daniel K. , ROTHENBERG, Mark E. , SCIORE, Paul , SHENOY, Suresh G. , SMITHSON, Glennda , SPYTEK, Kimberly A. , STONE, David J. , TAUPIER, Raymond J., Jr. , TSCHERNEV, Velizar T. , VERNET, Corine A.M. , VOSS, Edward Z. , ZERHUSEN, Bryan D. , ZHONG, Mei
IPC分类号： C12N1/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1572898A2
公开(公告)日：2005-09-14
申请号：EP02807098.5
申请日：2002-09-09
申请人： Curagen Corporation
发明人： AGEE, Michele L. , ALSOBROOK, John P.II , ANDERSON, David W. , BERGHS, Constance , BOLDOG, Ferenc L. , BURGESS, Catherine E. , CASMAN, Stacie J. , CATTERTON, Elina , CHANT, John S. , CHAUDHURI, Amitabha , CRABTREE, Julie , DIPIPPO, Vincent A. , EDINGER, Shlomit R. , EISEN, Andrew J. , ELLERMAN, Karen , GANGOLLI, Esha A. , GERLACH, Valerie L. , GIOT, Loic , GORMAN, Linda , GUO, Xiaojia , GUSEV, Vladimir Y. , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai , LEACH, Martin D. , LEPLEY, Denise M. , LI, Li , LIU, Xiaohong , MALYANKAR, Uriel M. , MILLER, Charles E. , OOI, Chean Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol E.A. , RIEGER, Daniel K. , ROTHENBURG, Mark E. , SHENOY, Suresh G. , SHIMKETS, Richard A. , SPADERNA, Steven K. , SPYTEK, Kimberly A. , TAUPIER, Raymond J.,jr. , TWOMLOW, Nancy , VERNET, Corine A.M. , VOSS, Edward Z. , ZERHUSEN, Bryan D. , ZHONG, Mei
IPC分类号： C12N1/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1537239A2
公开(公告)日：2005-06-08
申请号：EP03767213.6
申请日：2003-08-06
申请人： Curagen Corporation
发明人： BERGHS, Constance , ELLERMAN, Karen , GUO, Xiaojia , LI, Li , ORT, Tatiana , RIEGER, Daniel, K. , VERNET, Corine, A., M. , ZHONG, Mei
IPC分类号： C12Q1/68
摘要： Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obestiy, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.
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公开(公告)号：EP1581616A2
公开(公告)日：2005-10-05
申请号：EP03707305.3
申请日：2003-01-06
申请人： Curagen Corporation
发明人： ANDERSON, David W. , BALLINGER, Robert A. , BAUMGARTNER, Jason C. , BURGESS, Catherine E. , CASMAN, Stacie J. , CHANT, John S. , BERGHS, Constance , GANGOLLI, Esha A. , EDINGER, Shlomit R. , ELLERMAN, Karen , FURTAK, Katarzyna , GERLACH, Valerie L. , GILBERT, Jennifer A. , GUNTHER, Erik , GORMAN, Linda , GUO, Xiaojia , JI, Weizhen , LI, Li , LIU, Xiaohong , MILLER, Charles E. , MILLET, Isabelle , PADIGARU, Muralidhara , PATTURAJAN, Meera , RASTELLI, Luca , MACDOUGALL, John R. , MISHRA, Vishnu S. , PENA, Carol E.A. , SPADERNA, Steven K. , SHIMKETS, Richard A. , SMITHSON, Glennda , SPYTEK, Kimberly A. , STONE, David J. , SHENOY, Suresh G. , ORT, Tatiana , TAUPIER, Raymond J., Jr. , TCHERNEV, Velizar T. , VERNET, Corine A. , WOLENC, Adam R. , ZERHUSEN, Bryan D. , ZHONG, Mei
IPC分类号： C12N1/00
CPC分类号： C12N15/113 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/5421 , C07K14/705 , C07K14/82 , C12N9/1051 , C12N9/1211 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12Y204/0115
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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8.发明公开
公开(公告)号：EP1532238A2
公开(公告)日：2005-05-25
申请号：EP02778744.9
申请日：2002-11-05
申请人： Curagen Corporation
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHANT, John, S. , CHAPOVAL, Andrei , CHAUDHURI, Amitabha , EDINGER, Shlomit, R. , EISEN, Andrew , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GUO, Xiaojia , JI, Weizhen , KHRAMTSOV, Nikolai, V. , LEITE, Mario, W. , LI, Li , MEZES, Peter, S. , MILLET, Isabelle , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E.A. , RASTELLI, Luca , RIEGER, Daniel, K. , QUINN SENGER, Kerry, E. , SMITHSON, Glennda , SPADERNA, Steven, K. , SPYTEK, Kiberly, A. , STONE, David, J. , TWOMLOW, Nancy , VERNET, Corine, A.M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHIONG, Mei
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1492807A2
公开(公告)日：2005-01-05
申请号：EP02806720.5
申请日：2002-08-02
申请人： Curagen Corporation
发明人： ZERHUSEN, Bryan, D , PATTURAJAN, Meera , KEKUDA, Ramesh , MILLER, Charles, E , RIEGER, Daniel,K , PENA, Carol,E, A , SHIMKETS, Richard, A , LI,Li , BERGHS, Constance , ZHONG, Mei , CASMAN, Stacie, J , VOSS, Edward, Z , BOLDOG,Ferenc, L , PADIGARU, Muralidhara , SMITHSON, Glennda , SHENOY, Suresh, G , JI, Weizhen , GORMAN, Linda , VERNET, Corine, A, M. , LEITE, Mario, W , GUO, Xiaojia , ANDERSON, David, W , SPYTEK, Kimberly,A , GERLACH, Valerie, L , BURGESS, Catherine, E , KHRAMTSOV, Nikolai, V , ORT, Tatiana , ELLERMAN, Karen , RASTELLI, Luca , AGEE, Michele, L , CHAUDHURI, Amitabha , CHANT, John, S , DIPIPPO, Vicent, A , EDINGER, Shlomit, R , EISEN, Andrew , GANGOLLI, Esha,A , GIOT, Loic , OOI, Chean, Eng , ROTHENBERG, Mark, E , SPADERNA, Steven,K , HJALT, Tord , LIU, Xiaohong , TAUPIER, Raymond J,Jr , CATTERTON, Elina
IPC分类号： C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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