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1.发明公开
公开(公告)号：EP1532238A2
公开(公告)日：2005-05-25
申请号：EP02778744.9
申请日：2002-11-05
申请人： Curagen Corporation
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHANT, John, S. , CHAPOVAL, Andrei , CHAUDHURI, Amitabha , EDINGER, Shlomit, R. , EISEN, Andrew , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GUO, Xiaojia , JI, Weizhen , KHRAMTSOV, Nikolai, V. , LEITE, Mario, W. , LI, Li , MEZES, Peter, S. , MILLET, Isabelle , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E.A. , RASTELLI, Luca , RIEGER, Daniel, K. , QUINN SENGER, Kerry, E. , SMITHSON, Glennda , SPADERNA, Steven, K. , SPYTEK, Kiberly, A. , STONE, David, J. , TWOMLOW, Nancy , VERNET, Corine, A.M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHIONG, Mei
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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2.发明公开NOVEL ANTIBODIES THAT BIND TO ANTIGENIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING THE ANTIGENS, AND METHOD OF USE 审中-公开WHAT抗体与抗原多肽结合NUCLEIC其中所述的抗原代码，使用方法
公开(公告)号：EP1390057A2
公开(公告)日：2004-02-25
申请号：EP02763906.1
申请日：2002-04-03
申请人： Curagen Corporation
发明人： PADIGARU, Muralidhara , SHENOY, Suresh, G. , KEKUDA, Ramesh , RASTELLI, Luca , MEZES, Peter, S. , SMITHSON, Glennda , GUO, Xiaojia , GERLACH, Valerie , CASMAN, Stacie, J. , BOLDOG, Ferenc, L. , LI, Li , ZERHUSEN, Bryan, D. , TCHERNEV, Velizar, T. , GANGOLLI, Esha, A. , VERNET, Corine, A., M. , SPYTEK, Kimberly, A. , MALYANKAR, Uriel M. , PATTURAJAN, Meera , MILLER, Charles, E. , TAUPIER, Raymond J., Jr. , HEYES, Melvyn P. , JU, Jingfang , PEYMAN, John A. , CATTERTON, Elina , MACDOUGALL, John R. , EDINGER, Shlomit R. , STONE, David J. , MAZUR, Ann
IPC分类号： A61K38/16
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12Y204/0115
摘要： Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
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公开(公告)号：EP1261712B1
公开(公告)日：2006-12-13
申请号：EP01920218.3
申请日：2001-03-05
申请人： Curagen Corporation
发明人： VERNET, Corine, A., M. , FERNANDES, Elma , SHIMKETS, Richard, A. , HERRMANN, John, L. , MAJUMDER, Kumud , MACDOUGALL, John , MISHRA, Vishnu , MEZES, Peter, S. , RASTELLI, Luca
IPC分类号： C12N15/12 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , G01N33/68 , C12Q1/68 , A61K38/17 , A61K31/70 , A61K39/395 , C12N1/21 , C12N5/10
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C07K14/54 , C07K14/70571 , Y02A50/423 , Y10T436/143333
摘要： Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1638986A1
公开(公告)日：2006-03-29
申请号：EP02799178.5
申请日：2002-11-05
申请人： Curagen Corporation
发明人： AGEE, Michele, L. , ALSOBROOK, John, P. II , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine E. , CHANT, John S. , CHAUDHURI, Amitabha , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha, A. , GORMAN, Linda , GERLACH, Valerie, L. , JI, Weizhen , KEKUDA; Ramesh , KHRAMTSOV, Nikolai, V. , LI, Li , MALYANKAR, Uriel M. , MACDOUGALL, John, R. , MEZES, Peter, S. , MILLER, Charles, E. , MILLET, Isabelle , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , RASTELLI, Luca , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , TAUPIER, Raymond, J. Jr. , VERNET, Corine, A. M. , ZERHUSEN, Bryan, D. , ZHONG, Mel
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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5.发明公开HUMAN PROTEINS, POLYNUCLEOTIDES ENCODING THEM AND METHODS OF USING THE SAME 审中-公开人类蛋白质，多核苷酸编码它们及其使用方法
公开(公告)号：EP1349930A2
公开(公告)日：2003-10-08
申请号：EP01977537.8
申请日：2001-10-05
申请人： Curagen Corporation
发明人： SHIMKETS, Richard, A. , TAUPIER, Raymond, J., Jr. , BURGESS, Catherine, E. , ZERHUSEN, Bryan, D. , MEZES, Peter, S. , RASTELLI, Luca , MALYANKAR, Uriel, M. , GROSSE, William, M. , ALSOBROOK, John, P., II , LEPLEY, Denise, M. , SPYTEK, Kimberly, Ann , LI, Li , EDINGER, Shlomit , GERLACH, Valerie , ELLERMAN, Karen , MACDOUGALL, John , GUNTHER, Erik , MILLET, Isabelle , STONE, David , SMITHSON, Glennda , SZEKERES, Edward S., Jr.
IPC分类号： C12N15/12 , C07K14/47 , C07K14/475 , C07K14/705 , C12N15/63 , C12N1/21 , C12N5/10 , C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12Q2600/156 , C12Q2600/158
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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6.发明公开
公开(公告)号：EP1572922A2
公开(公告)日：2005-09-14
申请号：EP03726032.0
申请日：2003-03-06
申请人： Curagen Corporation
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHAUDHURI, Amitabha , COLMAN, Steven, D. , EDINGER, Shlomit, R. , ETTENBERG, Seth , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, Linda , GUO, Xiaojia , KEKUDA, Ramesh , LI, Li , MACLACHLAN, Timothy , MALYANKAR, Uriel, M. , MEZES, Peter, S. , MILLER, Charles, E. , MILLET, Isabelle , PATTURAJAN, Meera , PEYMAN, John
IPC分类号： C12N1/00
摘要： The present invention relates to novel polypeptides, and the nucleic acids encoding them, having properties related to stimulation of biochemical or physiological responses in a cell, a tissue, an organ or an organism. More particularly, the novel polypeptides are gene products of novel genes, or are specified biologically active fragments or derivatives thereof. Methods of use encompass diagnostic and prognostic assay procedures as well as methods of treating diverse pathological conditions.
摘要翻译： 本发明涉及新的多肽和编码它们的核酸，其具有与刺激细胞，组织，器官或生物体中的生化或生理反应有关的性质。 更具体地说，新多肽是新基因的基因产物，或者是特定的生物活性片段或衍生物。 使用方法包括诊断和预后测定程序以及治疗不同病理状况的方法。
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公开(公告)号：EP1261712A2
公开(公告)日：2002-12-04
申请号：EP01920218.3
申请日：2001-03-05
申请人： Curagen Corporation
发明人： VERNET, Corine, A., M. , FERNANDES, Elma , SHIMKETS, Richard, A. , HERRMANN, John, L. , MAJUMDER, Kumud , MACDOUGALL, John , MISHRA, Vishnu , MEZES, Peter, S. , RASTELLI, Luca
IPC分类号： C12N15/12 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , G01N33/68 , C12Q1/68 , A61K38/17 , A61K31/70 , A61K39/395 , C12N1/21 , C12N5/10
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C07K14/54 , C07K14/70571 , Y02A50/423 , Y10T436/143333
摘要： Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：EP1232266A2
公开(公告)日：2002-08-21
申请号：EP01918899.4
申请日：2001-03-20
申请人： Curagen Corporation
发明人： TAUPIER, Raymond, J., Jr. , MAJUMDER, Kumud , SPADERNA, Steven, K. , SMITHSON, Glenda , MEZES, Peter, S. , VERNET, Corine, A., M.
CPC分类号： C07K14/47
摘要： The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
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9.发明公开NOVEL ANTIBODIES THAT BIND TO ANTIGENIC POLYPEPTIDES, NUCLEIC ACIDS AND ENCODINGTHE ANTIGENS, AND METHODS OF USE. 审中-公开新抗原多肽结合的抗体ANTI编码基因NUCLEIC和使用方法
公开(公告)号：EP1430110A2
公开(公告)日：2004-06-23
申请号：EP02736496.7
申请日：2002-03-08
申请人： Curagen Corporation
发明人： RASTELLI, Luca , MEZES, Peter, S. , SMITHSON, Glennda , GUO, Xiaojia , GERLACH, Valerie , CASMAN, Stacie, J. , BOLDOG, Ferenc L. , LI, Li , ZERHUSEN, Bryan, D. , TCHERNEV, Velizar, T. , GANGOLLI, Esha, A. , VERNET, Corine, A., M. , PENA, Carol, E.A. , BURGESS, Catherine, E. , LIU, Xiaohong , SPYTEK, Kimberly, A. , RIEGER, Daniel, K.A. , GORMAN, Linda , SPADERNA, Steven, K. , VOSS, Edward, Z. , ANDERSON, David, W. , PATTURAJAN, Meera , MILLER, Charles, E. , TAUPIER, Raymond J. jr. , PADIGARU, Muralidhara , SHENOY, Suresh G. , KEKUDA, Ramesh , GUSEV, Vladimir Y. , POCHART, Pascale, F.-J. , ZHONG, Mei , MISHRA, Vishnu , ALSOBROOK, John, P. II , LEPLEY, Denise, M. , MALYANKAR, Uriel, M.
摘要： Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
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10.发明公开
公开(公告)号：EP1399537A2
公开(公告)日：2004-03-24
申请号：EP02726701.2
申请日：2002-04-03
申请人： Curagen Corporation
发明人： LI, Li , GERLACH, Valerie , LIU, Xiaohong , MILLER, Charles, E. , SPYTEK, Kimberly, A. , ZERHUSEN, Bryan, D. , PENA, Carol, E., A. , SHENOY, Suresh, G. , ZHONG, Haihong , SMITHSON, Glennda , CASMAN, Stacie, J. , BOLDOG, Ferenc, L. , VOSS, Edward, Z. , VERNET, Corine, A., M. , MACDOUGALL, John, R. , RASTELLI, Luca , ANDERSON, David, W. , ZHONG, Mei , MEZES, Peter, S. , FURTAK, Katarzyna , PATTURAJAN, Meera , BURGESS, Catherine E. , MALYANKAR, Uriel M. , SHIMKETS, Richard A. , TAUPIER, Raymond J., Jr. , EDINGER, Shlomit R. , MAZUR, Ann
IPC分类号： C12N1/00
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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