公开(公告)号：EP1401855A2

公开(公告)日：2004-03-31

申请号：EP02746584.8

申请日：2002-06-17

申请人： Curagen Corporation

发明人： SHIMKETS, Richard, A. ,  JEFFERS, Michael, E. ,  PRAYAGA, Sudhirdas, K. ,  BOLDOG, Ferenc, L. ,  YANG, Meijia ,  BURGESS, Catherine, E. ,  FERNANDES, Elma, R. ,  HERRMANN, John, L. ,  LAROCHELLE, William J. ,  LICHENSTEIN, Henri S. ,  GORMAN, Linda ,  ZHONG, Mei ,  PADIGARU, Muralidhara ,  PENA, Carol E., A. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  RIEGER, Daniel K. ,  GROSSE, William M.

IPC分类号： C07H21/04 ,  C12N15/11 ,  C12N15/85 ,  C12N15/86 ,  C07K5/00 ,  C07K17/00 ,  G01N33/50

CPC分类号： C07K14/50

摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.

摘要翻译： 本发明提供了FGF-CX（一种新的分离的多肽）以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽，多核苷酸或其片段的任何衍生物，变体，突变体或片段的抗体 抗体。 本发明另外提供了其中将FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及其它用途的方法。

公开(公告)号：EP1383533A2

公开(公告)日：2004-01-28

申请号：EP02723842.7

申请日：2002-04-11

申请人： Curagen Corporation ,  Millennium Pharmaceuticals, Inc.

发明人： PENA, Carol, E., A. ,  GUO, Xiaojia ,  SHIMKETS, Richard, A. ,  PADIGARU, Muralidhara ,  KEKUDA, Ramesh ,  SPYTEK, Kimberly, A. ,  MEHRABAN, Fuad ,  TOPPER, James, N. ,  MALYANKAR, Uriel, M. ,  WASSERMAN, Scott ,  EDINGER, R. Shlomit ,  SMITHSON, Glennda ,  GUNTHER, Erik ,  KOMUVES, Laszlo

IPC分类号： A61K39/00

CPC分类号： C07K14/47

摘要： Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

公开(公告)号：EP1352065A2

公开(公告)日：2003-10-15

申请号：EP01993342.3

申请日：2001-12-19

申请人： Curagen Corporation

发明人： GANGOLLI, Esha, A. ,  PATTURAJAN, Meera ,  VERNET, Corine, A., M. ,  MALYANKAR, Uriel, M. ,  KEKUDA, Ramesh ,  STONE, David, J. ,  ANDERSON, David ,  SHIMKETS, Richard, A. ,  BURGESS, Catherine, E. ,  ZERHUSEN, Bryan, D. ,  LIU, Xiaohong ,  SPYTEK, Kimberly, A. ,  CASMAN, Stacie, J. ,  BOLDOG, Ferenc, L. ,  SMITHSON, Glennda ,  LI, li ,  JI, Weizhen

IPC分类号： C12N15/12 ,  C07K14/485 ,  C07K16/22 ,  C12Q1/68 ,  G01N33/50 ,  A61K31/7088 ,  A61K38/18

CPC分类号： C07K14/435 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：EP1250456A2

公开(公告)日：2002-10-23

申请号：EP01900897.8

申请日：2001-01-05

申请人： Curagen Corporation

发明人： SHIMKETS, Richard, A. ,  LEACH, Martin, D.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The invention provides nucleic acids containing single-nucleotide polymorphisms identified for transcribed human sequences, as well as methods of using the nucleic acids.

公开(公告)号：EP1235908A2

公开(公告)日：2002-09-04

申请号：EP00982559.7

申请日：2000-12-08

申请人： Curagen Corporation

发明人： PRAYAGA, Sudhirdas, K. ,  SHIMKETS, Richard, A.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  G01N33/53 ,  C12Q1/68 ,  G01N33/68 ,  G01N33/50 ,  A61K38/17

摘要： The invention provides polypeptides, designated herein as NOV polypeptides, as well as polynucleotides encoding NOV polypeptides, and antibodies that immunospecifically-bind to NOV polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the NOV polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.

公开(公告)号：EP1220918A2

公开(公告)日：2002-07-10

申请号：EP00968517.3

申请日：2000-09-29

申请人： Curagen Corporation

发明人： BURGESS, Catherine ,  SHIMKETS, Richard, A. ,  BOLDOG, Ferenc, L. ,  YANG, Meijia ,  LAROCHELLE, William ,  MINSKOFF, Stacey

IPC分类号： C12N15/12 ,  C07K14/50 ,  G01N33/53 ,  C12Q1/68 ,  A61K38/18 ,  A61K31/70 ,  A61K39/395

CPC分类号： C07K14/503 ,  A61K38/00 ,  A61K2039/505

摘要： The present invention provides HDGFX, a novel isolated polypeptide, as well as a polynucleotide encoding HDGFX and antibodies that immunospecifically bind to HDGFX or any derivative, variant, mutant, or fragment of the HDGFX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the HDGFX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.

公开(公告)号：EP1198584A1

公开(公告)日：2002-04-24

申请号：EP00943423.4

申请日：2000-06-02

申请人： Curagen Corporation

发明人： SHIMKETS, Richard, A.

IPC分类号： C12Q1/00

CPC分类号： C12Q1/6809 ,  C12Q2525/191 ,  C12Q2525/131

摘要： The present invention relates to methods for mapping expressed nucleic acid sequences to their chromosomal location. The invention also relate to methods for mapping gene response patterns in hybrid cells containing expressed genes located on exogenous chromosomal segments.

公开(公告)号：EP1198563A2

公开(公告)日：2002-04-24

申请号：EP00952219.4

申请日：2000-07-27

申请人： Curagen Corporation

发明人： JEFFERS, Michael ,  SHIMKETS, Richard, A. ,  PRAYAGA, Sudhirdas, K. ,  BOLDOG, Ferenc, L. ,  YANG, Meijia ,  BURGESS, Catherine ,  FERNANDES, Elma ,  HERRMANN, John, L. ,  LAROCHELLE, William, J. ,  LICHENSTEIN, Henri

IPC分类号： C12N15/00

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505

摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.

公开(公告)号：EP1194545A2

公开(公告)日：2002-04-10

申请号：EP00941673.6

申请日：2000-06-23

申请人： Curagen Corporation

发明人： SHIMKETS, Richard, A. ,  FERNANDES, Elma ,  VERNET, Corine ,  YANG, Meijia ,  BOLDOG, Ferenc, L. ,  HERRMANN, John, L.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K14/575 ,  C07K14/705 ,  A61K38/17 ,  C07K16/18 ,  C07K16/28 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K14/47 ,  C07K14/515 ,  C07K14/575 ,  C07K14/705

摘要： The invention provides novel polypeptides, designated herein as SECX polypeptides, as well as polynucleotides encoding SECX polypeptides. Also provided are antibodies that immunospecifically-bind to SECX polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the SECX polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.

公开(公告)号：EP1144439A3

公开(公告)日：2002-02-06

申请号：EP00957527.5

申请日：2000-08-18

申请人： Curagen Corporation ,  GENENTECH, INC.

发明人： LEWIN, David ,  SHIMKETS, Richard, A. ,  LASKY, Lawrence ,  TAILLON, Bruce ,  GOLD, Steven

IPC分类号： C12N15/12 ,  C12Q1/68 ,  C07K14/52

CPC分类号： C07K14/521