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公开(公告)号：EP1817287B1
公开(公告)日：2010-02-10
申请号：EP05851607.1
申请日：2005-11-10
发明人： ARGADE, Ankush, B., Rigel Pharmaceuticals, Inc. , GOODSON, Theodore, Junior , HERRON, David, Kent , JOSEPH, Sajan , LEPORE, Salvatore, Donato , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , MERRITT, Leander , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D211/46 , C07D213/75 , C07D401/12 , C07D401/14 , C07D417/12 , C07D295/18 , C07D409/14 , C07D413/12 , C07D333/38 , C07D409/06 , A61K31/4427 , A61P7/00 , A61K31/381 , A61K31/44 , C07C271/16
CPC分类号： C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
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公开(公告)号：EP1483265B1
公开(公告)日：2006-11-22
申请号：EP03711146.5
申请日：2003-03-04
发明人： CLAYTON, Joshua, Ryan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , MALHOTRA, Sushant , MARQUART, Angela, Lynn , MCLEAN, Johnathan, Alexander , MENDEL, David , BURKHOLDER, Timothy, Paul , LI, Yihong , REEL, Jon, Kevin , SULLIVAN, John Morris , BERRIDGE, Brian Raymond , RUEGG, Charles Edward
IPC分类号： C07D487/06 , A61P25/08
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
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公开(公告)号：EP1644334B1
公开(公告)日：2008-01-02
申请号：EP04785659.6
申请日：2004-04-13
发明人： FRANCISKOVICH, Jeffry, Bernard , HERRON, David, Kent , LINEBARGER, Jared, Harris , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , MERRITT, Leander , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , WEIGEL, Leland, Otto , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D213/81 , C07D401/14 , C07D211/46 , C07C317/46 , C07C323/62 , C07D207/12 , C07D213/79
CPC分类号： C07D213/79 , C07C317/46 , C07C323/62 , C07C2601/14 , C07D207/12 , C07D211/46 , C07D213/81 , C07D401/14
摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor (I).
摘要翻译： 本申请涉及如本文所定义的式I的化合物（或其前药或该化合物或其前药的药学上可接受的盐），其药物组合物及其作为因子Xa和/或凝血酶抑制剂的用途 作为其制备方法及其中间体（I）。
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公开(公告)号：EP1670783A2
公开(公告)日：2006-06-21
申请号：EP04817758.8
申请日：2004-09-24
发明人： FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HERRON, David, Kent , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , MERRITT, Leander , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/12 , C07D401/14 , C07D213/81 , C07D417/14 , C07D409/14 , C07D409/12 , C07C65/21 , C07D295/14 , C07D498/04 , C07D317/30
CPC分类号： C07C49/84 , C04B35/632 , C07C65/05 , C07C65/21 , C07D213/81 , C07D295/155 , C07D317/30 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1644334A1
公开(公告)日：2006-04-12
申请号：EP04785659.6
申请日：2004-04-13
发明人： FRANCISKOVICH, Jeffry, Bernard , HERRON, David, Kent , LINEBARGER, Jared, Harris , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , MERRITT, Leander , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , WEIGEL, Leland, Otto , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D213/81 , C07D401/14 , C07D211/46 , C07C317/46 , C07C323/62 , C07D207/12 , C07D213/79
CPC分类号： C07D213/79 , C07C317/46 , C07C323/62 , C07C2601/14 , C07D207/12 , C07D211/46 , C07D213/81 , C07D401/14
摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor (I).
摘要翻译： 本申请涉及如本文所定义的式I化合物（或其前体药物或其药学上可接受的盐），其药物组合物及其作为因子Xa和/或凝血酶抑制剂的用途，以及 作为其制备方法及其中间体（I）。
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公开(公告)号：EP1307444B1
公开(公告)日：2007-10-03
申请号：EP01958825.0
申请日：2001-07-18
发明人： HERRON, David, Kent , JOSEPH, Sajan , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , SMITH, Gerald, Floyd , WAID, Philip, Parker , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D213/81 , C07D237/24 , A61K31/4402 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61P7/02
CPC分类号： C07D401/14 , C07D237/24 , C07D403/04
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1817287A1
公开(公告)日：2007-08-15
申请号：EP05851607.1
申请日：2005-11-10
发明人： ARGADE, Ankush, B., Rigel Pharmaceuticals, Inc. , GOODSON, Theodore, Junior , HERRON, David, Kent , JOSEPH, Sajan , LEPORE, Salvatore, Donato , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , MERRITT, Leander , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D211/46 , C07D213/75 , C07D401/12 , C07D401/14 , C07D417/12 , C07D295/18 , C07D409/14 , C07D413/12 , C07D333/38 , C07D409/06 , A61K31/4427 , A61P7/00 , A61K31/381 , A61K31/44 , C07C271/16
CPC分类号： C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
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公开(公告)号：EP1483265A1
公开(公告)日：2004-12-08
申请号：EP03711146.5
申请日：2003-03-04
发明人： CLAYTON, Joshua, Ryan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , MALHOTRA, Sushant , MARQUART, Angela, Lynn , MCLEAN, Johnathan, Alexander , MENDEL, David , BURKHOLDER, Timothy, Paul , LI, Yihong , REEL, Jon, Kevin , SULLIVAN, John Morris , BERRIDGE, Brian Raymond , RUEGG, Charles Edward
IPC分类号： C07D487/06 , A61P25/08
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
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9.发明公开
公开(公告)号：EP1456175A1
公开(公告)日：2004-09-15
申请号：EP02786700.1
申请日：2002-12-02
发明人： HERRON, David, Kent , JOSEPH, Sajan , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , WAID, Philip, Parker , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D213/82 , A61K31/44 , C07D401/14 , C07D453/02 , C07D401/12 , C07D213/81 , A61P7/02
CPC分类号： C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D453/02
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1819693B1
公开(公告)日：2009-08-26
申请号：EP05851697.2
申请日：2005-11-15
发明人： FRANCISKOVICH, Jeffry, Bernard , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/00 , C07D409/00 , C07D401/12 , C07D409/12 , C07D213/75 , C07D409/14 , C07C271/16 , C07C235/64 , A61K31/4465 , A61K31/4436 , A61P7/02
CPC分类号： C07D213/75 , C07C235/64 , C07C237/06 , C07C271/16 , C07C275/10 , C07C275/16 , C07C275/26 , C07C275/28 , C07C275/30 , C07D211/22 , C07D211/46 , C07D295/088 , C07D295/192 , C07D295/205 , C07D295/215 , C07D401/12 , C07D409/12 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
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