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公开(公告)号：EP1140903B1
公开(公告)日：2004-08-04
申请号：EP99964279.6
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , DENNY, Carl, Penman , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D409/14 , C07D405/14 , C07D213/74 , A61K31/395 , A61K31/435 , A61K31/495 , A61P7/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
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公开(公告)号：EP1019045A1
公开(公告)日：2000-07-19
申请号：EP98932921.4
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , KYLE, Jeffrey, Alan , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/505 , C07D209/04 , C07D209/12 , C07D209/18 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D249/16 , C07D401/12 , C07D403/12 , C07D409/12
CPC分类号： C07D401/14 , C07D209/08 , C07D209/30 , C07D231/56 , C07D235/06 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP0963370A1
公开(公告)日：1999-12-15
申请号：EP97952325.0
申请日：1997-12-08
发明人： FISHER, Matthew, J. , FRANCISKOVICH, Jeffry, Bernard , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , SCARBOROUGH, Robert, M. , SMYTH, Mark , SU, Ting
CPC分类号： C07C311/06 , C07C311/19 , C07C2601/14 , C07D211/62
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.
摘要翻译： 公开了与哺乳动物整联蛋白相关的新化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗血栓形成或再狭窄病症。
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公开(公告)号：EP1819693B1
公开(公告)日：2009-08-26
申请号：EP05851697.2
申请日：2005-11-15
发明人： FRANCISKOVICH, Jeffry, Bernard , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/00 , C07D409/00 , C07D401/12 , C07D409/12 , C07D213/75 , C07D409/14 , C07C271/16 , C07C235/64 , A61K31/4465 , A61K31/4436 , A61P7/02
CPC分类号： C07D213/75 , C07C235/64 , C07C237/06 , C07C271/16 , C07C275/10 , C07C275/16 , C07C275/26 , C07C275/28 , C07C275/30 , C07D211/22 , C07D211/46 , C07D295/088 , C07D295/192 , C07D295/205 , C07D295/215 , C07D401/12 , C07D409/12 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1819693A1
公开(公告)日：2007-08-22
申请号：EP05851697.2
申请日：2005-11-15
发明人： FRANCISKOVICH, Jeffry, Bernard , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/00 , C07D409/00 , C07D401/12 , C07D409/12 , C07D213/75 , C07D409/14 , C07C271/16 , C07C235/64 , A61K31/4465 , A61K31/4436 , A61P7/02
CPC分类号： C07D213/75 , C07C235/64 , C07C237/06 , C07C271/16 , C07C275/10 , C07C275/16 , C07C275/26 , C07C275/28 , C07C275/30 , C07D211/22 , C07D211/46 , C07D295/088 , C07D295/192 , C07D295/205 , C07D295/215 , C07D401/12 , C07D409/12 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1007037A1
公开(公告)日：2000-06-14
申请号：EP98932926.3
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： A61K31/38 , A61K31/40 , A61K31/42 , A61K31/165 , A61K31/445 , C07C233/64 , C07D209/44 , C07D211/32 , C07D333/06
CPC分类号： C07C271/66 , A61K31/00 , C07C257/18 , C07C259/18 , C07C271/64 , C07D209/44 , C07D211/60 , C07D261/20 , C07D333/38
摘要： This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1140905B1
公开(公告)日：2003-05-14
申请号：EP99967352.8
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong , KYLE,Jeffrey , Wiley,Michael
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D405/14 , C07D213/82 , A61K31/4545 , A61K31/4427 , A61P7/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14
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公开(公告)号：EP1140905A1
公开(公告)日：2001-10-10
申请号：EP99967352.8
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan, Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D405/14 , C07D213/82 , A61K31/4545 , A61K31/4427 , A61P7/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14
摘要： This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1140903A1
公开(公告)日：2001-10-10
申请号：EP99964279.6
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , DENNY, Carl, Penman , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D409/14 , C07D405/14 , C07D213/74 , A61K31/395 , A61K31/435 , A61K31/495 , A61P7/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1140881B1
公开(公告)日：2006-05-17
申请号：EP99964269.7
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong , Kyle, Jefferey.A
IPC分类号： C07D295/12 , C07D401/04 , C07D401/12 , C07D409/14 , C07D401/14 , A61K31/44 , A61K31/445
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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