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公开(公告)号：EP2870143A1
公开(公告)日：2015-05-13
申请号：EP13737175.3
申请日：2013-07-03
发明人： BILOTTA, Joseph Anthony , CHEN, Zhi , CHIN, Elbert , DING, Qingjie , ERICKSON, Shawn David , GABRIEL, Stephen Deems , KLUMPP, Klaus , MA, Han , MERTZ, Eric , PLANCHER, Jean-Marc , WEIKERT, Robert James
IPC分类号： C07D249/14 , C07D403/12 , A61K31/4196 , A61P31/14
CPC分类号： C07D249/14 , A61K31/4196 , A61K31/5377 , A61K38/21 , A61K38/55 , A61K45/06 , C07D403/12 , A61K2300/00
摘要： The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
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公开(公告)号：EP2717881A1
公开(公告)日：2014-04-16
申请号：EP12726438.0
申请日：2012-06-07
发明人： JAVANBAKHT, Hassan , KLUMPP, Klaus , REN, Suping , ZHANG, Zhuming
IPC分类号： A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/12 , C07H19/10 , C07H19/20
CPC分类号： C07H19/20 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/207 , Y02A50/385
摘要： The application provides methods for treatment or prophylaxis of dengue virus mediated diseases with compounds of Formula I wherein R1, R2a, R2b, R3, R4, R5 R6, R8a, R9 and R10 are as defined herein. The application further discloses methods for treatment or prophylaxis of dengue virus mediated diseases with pharmaceutical compositions comprising compounds of Formula I.
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公开(公告)号：EP1928475A2
公开(公告)日：2008-06-11
申请号：EP06778153.4
申请日：2006-08-03
IPC分类号： A61K31/7064 , A61K31/7076 , C07H19/10
摘要： The invention provides novel nucleoside compounds of formula I wherein R1, R2a, R2b, R3, R4, R5 R6, R8a, R9 and R10 are as defined herein which are useful for the treatment of Hepatitis C Virus (HCV) mediated diseases. The invention further provides methods for treatment or prophylaxis of HCV mediated diseases with compounds of formula I and pharmaceutical compositions comprising these compounds,
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