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23 条记录 (耗时 0.015 秒)

    Indole derivatives
    4.
    发明公开
    Indole derivatives 失效
    Indolderivate。

    公开(公告)号：EP0458207A2

    公开(公告)日：1991-11-27

    申请号：EP91108019.0

    申请日：1991-05-17

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Okada, Satoshi ,  Sawada, Kozo ,  Kayakiri, Natsuko ,  Saitoh, Yuki ,  Tanaka, Hirokazu ,  Hashimoto, Masashi

    IPC分类号： C07D209/12 ,  C07D209/14 ,  C07D403/10 ,  C07D405/06 ,  C07D413/10 ,  C07D417/10 ,  A61K31/40

    CPC分类号： C07D403/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D413/10 ,  C07D417/10 ,  Y02P20/55

    摘要： The present invention relates to novel indole derivatives and a pharmaceutically acceptable salt thereof which have pharmacological activities such as inhibitory activity on testosteron 5a-reductase and the like, to process for preparation thereof, to a pharmaceutical composition comprising the same and to a use of the same for manufacturing a medicament.

    摘要翻译： 本发明涉及下式的新的吲哚衍生物：其中R 1是羧基或被保护的羧基，R 2是氢，低级烷基或卤素，R 3是芳基或芳（低级）烷基 其各自可以具有合适的取代基，或下式的基团：A是可以被氧代或低级亚烯基取代的低级亚烷基，Q是羰基或低级亚烷基，X是或< CHEM>其中R 4是氢或低级烷基，R 5是氢，低级烷基或YZR 3，Y是键或低级亚烷基，Z是低级亚烷基，-O-或 其中R 6为氢，可具有合适的取代基或氨基保护基的低级烷基，芳基（低级）烷基及其药学上可接受的盐，其具有抑制活性的睾酮5α-还原酶和 类似物，其制备方法，涉及包含其的药物组合物及其用于制备药物的用途。

    Indolizin derivatives, process for their preparation and pharmaceutical composition containing them
    7.
    发明公开
    Indolizin derivatives, process for their preparation and pharmaceutical composition containing them 失效
    吲哚啉衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：EP0519353A3

    公开(公告)日：1993-04-14

    申请号：EP92109968.5

    申请日：1992-06-13

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Okada, Satoshi ,  Sawada, Kozo ,  Kuroda, Akio ,  Watanabe, Shinya ,  Tanaka, Hirokazu

    IPC分类号： C07D471/04 ,  A61K31/435

    CPC分类号： C07D471/04 ,  Y02P20/55

    摘要： A compound of the formula :

    wherein
    R 1 is carboxy or protected carboxy, R 2 is hydrogen, lower alkyl or halogen, R 3 is aryl or ar(lower)alkyl, each of which may have suitable substituent(s), [substituted carbamoyl]-(lower)alkyl, or a group of the formula :

    is heterocyclic group containing nitrogen atom, and
    n is 0 or 1, R 11 is hydrogen or lower alkyl, A is lower alkylene which may be substituted by oxo, or lower alkenylene, Q is carbonyl or lower alkylene, X is

    in which R 4 is hydrogen or lower alkyl, and R 5 is hydrogen, lower alkyl or Y-Z-R 3 , Y is bond or lower alkylene, Z is lower alkylene, lower alkenylene, -0-or

    in which R 6 is hydrogen, lower alkyl, ar(lower)alkyl which may have suitable substituent(s) or amino protective group,
    and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them.

    Indolizin derivatives, process for their preparation and pharmaceutical composition containing them
    8.
    发明公开
    Indolizin derivatives, process for their preparation and pharmaceutical composition containing them 失效
    吲嗪衍生物，它们的制备方法和含有它们的药物组合物。

    公开(公告)号：EP0519353A2

    公开(公告)日：1992-12-23

    申请号：EP92109968.5

    申请日：1992-06-13

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Okada, Satoshi ,  Sawada, Kozo ,  Kuroda, Akio ,  Watanabe, Shinya ,  Tanaka, Hirokazu

    IPC分类号： C07D471/04 ,  A61K31/435

    CPC分类号： C07D471/04 ,  Y02P20/55

    摘要： A compound of the formula :

    wherein

    R 1 is carboxy or protected carboxy,
    R 2 is hydrogen, lower alkyl or halogen,
    R 3 is aryl or ar(lower)alkyl, each of which may have suitable substituent(s), [substituted carbamoyl]-(lower)alkyl, or a group of the formula :


    is heterocyclic group containing nitrogen atom, and
    n is 0 or 1,
    R 11 is hydrogen or lower alkyl,
    A is lower alkylene which may be substituted by oxo, or lower alkenylene,
    Q is carbonyl or lower alkylene,
    X is

    in which
    R 4 is hydrogen or lower alkyl, and
    R 5 is hydrogen, lower alkyl or Y-Z-R 3 ,
    Y is bond or lower alkylene,
    Z is lower alkylene, lower alkenylene, -0-or

    in which R 6 is hydrogen, lower alkyl, ar(lower)alkyl which may have suitable substituent(s) or amino protective group,
    and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them.

    摘要翻译： 下式的化合物： worin - [R <1>是羧基或保护的羧基，R <2>是氢，低级烷基或卤素，R <3>为芳基或芳（低级）烷基，其中的每一个可以具有 合适的取代基（一个或多个）[substituiertem氨基甲酰基]（低级）烷基，或下式基团的：其中被杂环基团含有氮原子，且n为0或1，R <1> <1 >是氢或低级烷基，A是低级亚烷基可被氧代基，或低级亚烯基可以substituiertem，Q是羰基或低级亚烷基，X是其中R <4>是氢或低级烷基，且R <5 >是氢，低级烷基或YZR <3>，Y是键或低级亚烷基，Z是低级亚烷基，低级亚烯基，-O-或其中R <6>是氢，低级烷基，芳（低级） 可具有合适的取代基（一个或多个）或氨基保护基团，及其药学上可接受的盐或其烷基，处理用于制备药物和它们的组成包含它们。