ACOUSTIC PERFUSION DEVICES
    1.
    发明公开
    ACOUSTIC PERFUSION DEVICES 审中-公开
    声学灌注装置

    公开(公告)号:EP3234099A1

    公开(公告)日:2017-10-25

    申请号:EP15825713.9

    申请日:2015-12-18

    IPC分类号: C12M1/00 B01D43/00

    摘要: Acoustic perfusion devices for separating biological cells from other material in a fluid medium are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid medium is being drawn.

    摘要翻译: 公开了用于从流体介质中的其他材料分离生物细胞的声灌注装置。 这些装置包括连接到声室的入口端口,出口端口和收集端口。 超声换能器在声室中产生声驻波,其允许流体的连续流动通过采集端口被回收,同时保持声室内的生物细胞返回到流体介质从其中被抽出的生物反应器。

    ACOUSTOPHORETIC DEVICE WITH UNIFORM FLUID FLOW
    5.
    发明公开
    ACOUSTOPHORETIC DEVICE WITH UNIFORM FLUID FLOW 审中-公开
    具有均匀流体流动的ACOUSTOPHORETIC装置

    公开(公告)号:EP3164488A2

    公开(公告)日:2017-05-10

    申请号:EP15814616.7

    申请日:2015-07-02

    IPC分类号: C12N13/00

    CPC分类号: B01D21/283 B01D21/0045

    摘要: An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.

    摘要翻译: 公开了包括流体混合物的基本上垂直的流动路径以便改善颗粒/次要流体与主要流体的分离的声波输送装置。 垂直流动路径减小了由重力引起的声室中的速度不均匀性。 该装置包括其中产生多维声驻波的声室。 可以使用倾倒扩散器将流体引入声学腔室,其中多个入口进入声学腔室的底部附近,使得流动对称性降低重力驱动的流动不均匀性和入口混合物流动之间的任何流动干涉效应 进入声室并且连续重力驱动的粒子群落退出。