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公开(公告)号：EP1696030A1
公开(公告)日：2006-08-30
申请号：EP06007996.9
申请日：1998-09-14
申请人： GENENTECH, INC.
发明人： Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth , Botstein, David , Goddard, Audrey , Roy, Margart , Ferrara, Napoleone , Tumas, Daniel , Schwall, Ralph
IPC分类号： C12N15/12 , C07K14/515 , C12N15/86 , C12N5/10 , C07K16/18 , A61K38/18 , A61K39/395 , A61K39/44 , C07K19/00 , G01N33/68 , G01N33/53 , C12Q1/68
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00 , G01N2800/32 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： The present invention concerns isolated nucleic acid molecules encoding the TIE ligands NL1, NL5, NL8 and NL4, the protein encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码TIE配体NL1，NL5，NL8和NL4的分离的核酸分子，由这种核酸分子编码的蛋白质，以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：EP2067472A8
公开(公告)日：2010-06-02
申请号：EP08018727.1
申请日：2002-12-30
申请人： Genentech, Inc.
发明人： Frantz, Gretchen , Hillan, Kenneth , Phillips, Heidi , Polakis, Paul , Smith, Victoria , Spencer, Susan D. , Williams, P. Mickey , Wu, Thomas D. , Zhang, Zemin
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K51/1018 , A61K51/1045 , A61K2039/505 , C07K16/18
摘要： The present invention is directed to composition of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：EP1696029A1
公开(公告)日：2006-08-30
申请号：EP06007995.1
申请日：1998-09-14
申请人： GENENTECH, INC.
发明人： Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth , Botstein, David , Goddard, Audrey , Roy, Margart , Ferrara, Napoleone , Tumas, Daniel , Schwall, Ralph
IPC分类号： C12N15/12 , C07K14/515 , C12N15/86 , C12N5/10 , C07K16/18 , A61K38/18 , A61K39/395 , A61K39/44 , C07K19/00 , G01N33/68 , G01N33/53 , C12Q1/68
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00 , G01N2800/32 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： The present invention concerns isolated nucleic acid molecules encoding the TIE ligands NL1, NL5, NL8 and NL4, the protein encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码TIE配体NL1，NL5，NL8和NL4的分离的核酸分子，由这种核酸分子编码的蛋白质，以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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4.发明公开
公开(公告)号：EP1482040A3
公开(公告)日：2004-12-08
申请号：EP04012203.8
申请日：1998-09-14
申请人： Genentech Inc.
发明人： Fong, Sherman , Ferrara, Napoleone , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth , Williams, P. Mickey
IPC分类号： C12N15/12 , C07K14/475 , C07K14/515 , C07K16/22 , C12N5/10 , G01N33/53 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligand homologues NL2, NL3 and NL6 (FLS139), the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码新型TIE配体同源物NL2，NL3和NL6（FLS139）的分离的核酸分子，由这种核酸分子编码的蛋白质以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：EP1482041B1
公开(公告)日：2009-07-08
申请号：EP04012204.6
申请日：1998-09-14
申请人： Genentech, Inc.
发明人： Fong, Sherman , Ferrara, Napoleone , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth , Williams, P. Mickey
IPC分类号： C12N15/12 , C07K14/475 , C07K14/515 , C07K16/22 , C12N5/10 , G01N33/53 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
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6.发明公开Compositions and methods for the diagnosis and treatment of tumor 审中-公开Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
公开(公告)号：EP2067472A1
公开(公告)日：2009-06-10
申请号：EP08018727.1
申请日：2002-12-30
申请人： Genentech, Inc.
发明人： Frantz, Gretchen , Hillan, Kenneth , Phillips, Heidi , Polakis, Paul , Smith, Victoria , Spencer, Susan D. , Williams, P. Mickey , Wu, Thomas D. , Zhang, Zemin
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K51/1018 , A61K51/1045 , A61K2039/505 , C07K16/18
摘要： The present invention is directed to composition of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质的组合物以及使用这些物质组合物的方法。
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公开(公告)号：EP1482040B1
公开(公告)日：2006-06-07
申请号：EP04012203.8
申请日：1998-09-14
申请人： Genentech Inc.
发明人： Fong, Sherman , Ferrara, Napoleone , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth , Williams, P. Mickey
IPC分类号： C12N15/12 , C07K14/475 , C07K14/515 , C07K16/22 , C12N5/10 , G01N33/53 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
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公开(公告)号：EP2014770A3
公开(公告)日：2009-02-18
申请号：EP08012474.6
申请日：1998-10-29
申请人： Genentech, Inc.
发明人： Botstein, David, A. , Cohen, Robert, L. , Gurney, Austin, L. , Hillan, Kenneth , Lawrence, David, A. , Levine, Arnold, J. , Pennica, Diane , Roy, Margaret, Ann , Goddard, Audrey , Wood, William, I.
CPC分类号： C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2317/74 , C12Q1/6886 , C12Q2600/136
摘要： Wnt-l-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
摘要翻译： 提供了Wnt-1诱导的分泌蛋白（WISPs），其基因至少由Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体以及用于产生多肽的方法。
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公开(公告)号：EP2014770A2
公开(公告)日：2009-01-14
申请号：EP08012474.6
申请日：1998-10-29
申请人： Genentech, Inc.
发明人： Botstein, David, A. , Cohen, Robert, L. , Gurney, Austin, L. , Hillan, Kenneth , Lawrence, David, A. , Levine, Arnold, J. , Pennica, Diane , Roy, Margaret, Ann , Goddard, Audrey , Wood, William, I.
CPC分类号： C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2317/74 , C12Q1/6886 , C12Q2600/136
摘要： Wnt-l-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
摘要翻译： 提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。
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公开(公告)号：EP1724349A1
公开(公告)日：2006-11-22
申请号：EP06007999.3
申请日：1998-09-14
申请人： GENENTECH, INC.
发明人： Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth , Botstein, David , Goddard, Audrey , Roy, Margaret , Ferrara, Napoleone , Tumas, Daniel , Schwall, Ralph
IPC分类号： C12N15/12 , C07K14/515 , C12N15/86 , C12N5/10 , C07K16/18 , A61K38/18 , A61K39/395 , A61K39/44 , C07K19/00 , G01N33/68 , G01N33/53 , C12Q1/68
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00 , G01N2800/32 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： The present invention concerns isolated nucleic acid molecules encoding the TIE ligands NL1, NL5, NL8 and NL4, the protein encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码TIE配体NL1，NL5，NL8和NL4的分离的核酸分子，由这种核酸分子编码的蛋白质，以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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