利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.015 秒)

    Wisp polypeptides and therapeutical applications thereof
    4.
    发明公开
    Wisp polypeptides and therapeutical applications thereof 有权
    Wisp多肽及其治疗应用

    公开(公告)号：EP2180053A2

    公开(公告)日：2010-04-28

    申请号：EP10000199.9

    申请日：2001-10-12

    申请人： Genentech, Inc.

    发明人： Desnoyer, Luc ,  Filvaroff, Ellen H. ,  Pennica, Diane

    IPC分类号： C12N15/12 ,  C07K14/47 ,  A61K38/17 ,  C12N15/62

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/47

    摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.

    摘要翻译： 本发明涉及用于治疗和修复软骨的方法，所述软骨包括由损伤或退行性软骨疾病（包括关节炎）损伤的软骨，包括施用WISP多肽。 任选地，所述施用可以与一种或多种软骨剂（例如肽生长因子，分解代谢拮抗剂，骨关节，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或退行性软骨疾病损伤的软骨的治疗和修复，包括与标准手术技术组合施用WISP多肽。 或者，该方法提供了由损伤或退行性软骨疾病损伤的软骨的治疗和修复，包括施用先前用有效量的WISP多肽处理的软骨细胞。

    Polypeptides and nucleic acids encoding the same
    5.
    发明公开
    Polypeptides and nucleic acids encoding the same 审中-公开
    WNT-1-induzierbare基因

    公开(公告)号：EP2033970A3

    公开(公告)日：2009-06-17

    申请号：EP08013645.0

    申请日：1998-10-29

    申请人： Genentech, Inc.

    发明人： Levine, Arnold J. ,  Pennica, Diane

    IPC分类号： C07K14/47 ,  A61K38/17

    CPC分类号： G01N33/57484 ,  C07K14/47 ,  C07K2317/24 ,  C07K2319/02 ,  G01N33/68

    摘要： DNAs are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

    摘要翻译： 提供DNA，其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。