公开(公告)号：EP0900231A1

公开(公告)日：1999-03-10

申请号：EP97922303.0

申请日：1997-04-24

申请人： Heska Corporation

发明人： GRIEVE, Robert, B. ,  RUSHLOW, Keith, E. ,  HUNTER, Shirley, Wu ,  FRANK, Glenn, R. ,  STEIGLER, Gary, L. ,  GAINES, Patrick, J. ,  SILVER, Gary

IPC分类号： C07K ,  G01N33 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61P33 ,  C07H21 ,  C07K5 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N7 ,  C12N9 ,  C12N15 ,  C12P21 ,  A61K35

CPC分类号： C12N9/6408 ,  A61K35/00 ,  C07K16/40 ,  C12N9/48 ,  C12N9/641 ,  C12N9/6424 ,  C12N9/6472

摘要： The present invention relates to flea serine protease proteins and flea cysteine protease proteins; to flea serine protease and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

公开(公告)号：EP1328662A2

公开(公告)日：2003-07-23

申请号：EP01977740.8

申请日：2001-10-11

申请人： Heska Corporation

发明人： GAINES, Patrick, J. ,  WISNEWSKI, Nancy

IPC分类号： C12Q1/68 ,  C12P21/04 ,  C12P21/06 ,  C07H21/04 ,  A01N43/04 ,  C12N15/09

CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

摘要： The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea peritrophin activity, as weell as the use of such therapeutic compositions to treat animals.

公开(公告)号：EP1169343A2

公开(公告)日：2002-01-09

申请号：EP00918540.6

申请日：2000-04-07

申请人： Heska Corporation

发明人： BRANDT, Kevin, S. ,  GAINES, Patrick, J. ,  STINCHCOMB, Dan, T. ,  WISNEWSKI, Nancy

IPC分类号： C07K14/435 ,  C12N15/12 ,  C12N5/10 ,  C07K16/18 ,  G01N33/50 ,  A61K48/00 ,  A61K38/17

CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

摘要： The present invention relates to flea head, nerve cord, hindgut and malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.

公开(公告)号：EP1328662B1

公开(公告)日：2010-09-08

申请号：EP01977740.8

申请日：2001-10-11

申请人： Heska Corporation

发明人： GAINES, Patrick, J. ,  WISNEWSKI, Nancy

IPC分类号： C12Q1/68 ,  C12P21/04 ,  C12P21/06 ,  C07H21/04 ,  A01N43/04 ,  C12N15/09 ,  C07K14/435 ,  C12N15/11

CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

摘要： The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea peritrophin activity, as weell as the use of such therapeutic compositions to treat animals.

公开(公告)号：EP1578911A2

公开(公告)日：2005-09-28

申请号：EP02784031.3

申请日：2002-10-04

申请人： Heska Corporation

发明人： BRANDT, Kevin, S. ,  GAINES, Patrick, J. ,  STINCHCOMB, Dan, T. ,  WISNEWSKI, Nancy

IPC分类号： C12N1/00

CPC分类号： C07K14/4359

摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, antibodies, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.