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11 条记录 (耗时 0.019 秒)

    METHOD TO DETECT $i(DIROFILARIA IMMITIS) INFECTION
    2.
    发明公开
    METHOD TO DETECT $i(DIROFILARIA IMMITIS) INFECTION 失效
    用于确定心丝虫感染一

    公开(公告)号：EP0934529A1

    公开(公告)日：1999-08-11

    申请号：EP97941677.0

    申请日：1997-09-18

    申请人： Heska Corporation

    发明人： GRIEVE, Robert, B. ,  FRANK, Glenn, R. ,  MONDESIRE, Roy, R. ,  PORTER, James, P. ,  WISNEWSKI, Nancy

    IPC分类号： G01N33 ,  C07K1 ,  C07K14 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21

    CPC分类号： C07K14/4354 ,  G01N33/569 ,  G01N2333/4353

    摘要： The present invention includes a method to detect D. immitis infection in a host animal using a D. immitis Di33 protein to detect anti-D. immitis Di33 antibodies in a bodily fluid of the animal. Also included is a method to detect D. immitis infection in a host animal using a D. immitis anti-Di33 protein to detect Di33 proteins in a bodily fluid of the animal. The present invention also relates to D. immitis detection kits that include either a Di33 protein or an anti-Di33 antibody; such kits also include a composition to detect an immunocomplex between the anti-Di33 antibody and D. immitis Di33 protein. The present invention also includes Di33 proteins, nucleic acid molecules encoding such proteins, as well as recombinant molecules and recombinant cells comprising such nucleic acid molecules, and anti-Di33 antibodies. Also included are methods to produce such proteins, nucleic acid molecules and antibodies.

    FLEA HEAD, NERVE CORD, HINDGUT AND MALPIGHIAN TUBULE NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF
    8.
    发明公开
    FLEA HEAD, NERVE CORD, HINDGUT AND MALPIGHIAN TUBULE NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF 审中-公开
    核酸分子和HEAD，神经TRAIN，REAR和肠malphigian VESSEL跳蚤蛋白，其使用

    公开(公告)号：EP1578911A2

    公开(公告)日：2005-09-28

    申请号：EP02784031.3

    申请日：2002-10-04

    申请人： Heska Corporation

    发明人： BRANDT, Kevin, S. ,  GAINES, Patrick, J. ,  STINCHCOMB, Dan, T. ,  WISNEWSKI, Nancy

    IPC分类号： C12N1/00

    CPC分类号： C07K14/4359

    摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, antibodies, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.

    FLEA GABA RECEPTOR SUBUNIT NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF
    9.
    发明公开
    FLEA GABA RECEPTOR SUBUNIT NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF 审中-公开
    蚤GABA受体亚基编码核酸分子，蛋白质以及它们的用途

    公开(公告)号：EP1337641A2

    公开(公告)日：2003-08-27

    申请号：EP01998635.5

    申请日：2001-11-21

    申请人： Heska Corporation

    发明人： WISNEWSKI, Nancy ,  BRANDT, Kevin, S.

    IPC分类号： C12N15/12 ,  C07K14/705 ,  G01N33/53 ,  A61K38/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  G01N2500/04

    摘要： The present invention relates to flea GABA receptor subunit nucleic acid molecules; to flea GABA receptor subunit proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and inhibitory compounds, particularly those that specifically inhibit flea GABA receptor subunit activity, as well as the use of such therapeutic compositions to treat animals.