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1.发明公开FLEA AND TICK OCTOPAMINE RECEPTOR NUCLEIC ACID MOLECULES, PROTEINS AND THEREOF 审中-公开从跳蚤和蜱及比重OCTOPAMINREZEPTOR核酸分子和蛋白质
公开(公告)号：EP1543325A4
公开(公告)日：2008-02-20
申请号：EP03765537
申请日：2003-07-11
申请人： HESKA CORP
发明人： BRANDT KEVIN S
IPC分类号： C07K14/705 , G01N33/50 , A61K45/00 , A61P25/00 , A61P33/14 , A61P43/00 , C07H21/04 , C07K14/435 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15
CPC分类号： C07K14/70571 , C07K14/43527 , C07K14/4359 , C12N2799/021 , Y10S530/858
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2.发明公开FLEA PERITROPHIN NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF 有权跳蚤，蛋白质及其应用的核酸分子OFF PERITROPHIN
公开(公告)号：EP1328662A2
公开(公告)日：2003-07-23
申请号：EP01977740.8
申请日：2001-10-11
申请人： Heska Corporation
CPC分类号： C07K14/4359 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C12N2799/021
摘要： The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea peritrophin activity, as weell as the use of such therapeutic compositions to treat animals.
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公开(公告)号：EP3355917A1
公开(公告)日：2018-08-08
申请号：EP16775160.1
申请日：2016-09-27
发明人： ROSE, Horst , REICHE, Dania-Birte , TAMMEN, Harald
IPC分类号： A61K39/35 , A61K39/385 , C12N15/62 , C07K17/06 , C07K19/00
CPC分类号： A61K39/35 , A61K38/00 , A61K39/385 , A61K2039/552 , A61K2039/55505 , A61K2039/575 , A61K2039/577 , A61K2039/622 , C07K7/06 , C07K14/43531 , C07K14/4359 , C07K14/47 , C07K2319/10 , C07K2319/21 , C07K2319/33 , C12N7/00 , C12N2740/16033 , C12N2740/16071
摘要： The present invention relates to (isolated) recombinant proteins, also referred to as improved MAT (iMAT) molecules, comprising at least one translocation module, at least one targeting module and at least one antigen module, wherein at least one cysteine residue is substituted with a different amino acid residue. Such iMAT molecules are useful specifically as vaccines, e.g. for therapy and/or prevention of allergies and/or infectious diseases and/or prevention of transmission of infectious diseases in animals, more preferably ruminants, pigs, dogs and/or cats, but excluding equines. The present invention further relates to nucleic acids encoding such iMAT molecules, corresponding vectors and primary cells or cell lines.
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4.发明公开Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 审中-公开该Nervenkords头的蛋白质和Nukleinsäuremolekule，肠道的更深部分和跳蚤和您使用的马氏船只。
公开(公告)号：EP1710252A3
公开(公告)日：2006-12-27
申请号：EP06010625.9
申请日：2000-04-07
申请人： Heska Corporation
CPC分类号： C07K14/4359 , A61K38/00 , A61K48/00 , A61K2039/505 , C12N2799/021
摘要： The present invention relates to flca head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.
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5.发明授权NOVEL ECTOPARASITE SALIVA PROTEINS AND APPARATUS TO COLLECT SUCH PROTEINS 失效新的蛋白质从EKTOPARASITENSPEICHEL和设备收集它
公开(公告)号：EP0784682B1
公开(公告)日：2004-04-28
申请号：EP95938243.3
申请日：1995-10-06
申请人： Heska Corporation
CPC分类号： C07K16/18 , A61K38/00 , A61K39/00 , C07K14/4359 , G01N1/24
摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection apparatus capable of collecting ectoparasite saliva proteins substantially free of contaminating material. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.
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6.发明公开DNA MOLECULES ENCODING CTENOCEPHALIDES FELIS GLUTAMATE GATED CHLORIDE CHANNELS 审中-公开DNA分子受控Ctenophalides FELIS CODE谷氨酸氯离子通道。
公开(公告)号：EP1012231A4
公开(公告)日：2003-03-19
申请号：EP98940839
申请日：1998-08-10
申请人： MERCK & CO INC
发明人： WARMKE JEFFREY W , ETTER ADRIAN , CULLY DORIS F , PARESS PHILIP S , COHEN CHARLES J , BROCHU RICHARD
IPC分类号： C12N15/09 , C07K14/435 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/02 , C12N1/20 , C07H21/04 , C12N15/00
CPC分类号： C07K14/4359 , C07K14/70571
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7.发明授权Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 有权核酸分子和所述头部的蛋白，神经干，后肠和跳蚤和它们的使用的马氏容器
公开(公告)号：EP1947112B1
公开(公告)日：2012-05-16
申请号：EP08075174.6
申请日：2000-04-07
申请人： Heska Corporation
CPC分类号： C07K14/4359 , A61K38/00 , A61K48/00 , A61K2039/505 , C12N2799/021
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8.发明公开Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 有权核酸分子和所述头部的蛋白，神经干，后肠和跳蚤和它们的使用的马氏容器
公开(公告)号：EP1947112A3
公开(公告)日：2008-08-06
申请号：EP08075174.6
申请日：2000-04-07
申请人： Heska Corporation
CPC分类号： C07K14/4359 , A61K38/00 , A61K48/00 , A61K2039/505 , C12N2799/021
摘要： The present invention relates to isolated nucleic acid molecule selected from the group consisting of:
(a) an isolated nucleic acid molecule comprising a nucleic acid sequence that hybridizes to a polynucleotide sequence encoding a protein consisting of SEQ ID NO:1873 under conditions comprising (a) hybridizing in a solution comprising IX SSC and 0% formamide, at a temperature of about 37°C and (b) washing in a solution comprising IX SSC and 0% formamide, at a temperature of about 47.5°C; and,
(b) an isolated nucleic acid molecule fully complementary in sequence to the nucleic acid molecule of (a).
The invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and inhibitory compounds. Also included are therapeutic compositions comprising such proteins, nucleic acids, or protective compounds derived from proteins of the present invention.-
9.发明公开FLEA AND TICK OCTOPAMINE RECEPTOR NUCLEIC ACID MOLECULES, PROTEINS AND THEREOF 审中-公开从蚤TICK AND及比重OCTOPAMINREZEPTOR核酸分子和蛋白质
公开(公告)号：EP1543325A2
公开(公告)日：2005-06-22
申请号：EP03765537.0
申请日：2003-07-11
申请人： Heska Corporation
发明人： BRANDT, Kevin, S.
CPC分类号： C07K14/70571 , C07K14/43527 , C07K14/4359 , C12N2799/021 , Y10S530/858
摘要： The present invention relates to tick octopamine receptor nucleic acid molecules; to tick octopamine receptor proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes inhibitory compounds, particularly those that specifically inhibit tick octopamine receptor activity, as well as the use of such compounds to treat animals.
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10.发明公开NOVEL ECTOPARASITE SALIVA PROTEINS AND APPARATUS TO COLLECT SUCH PROTEINS 失效使用蛋白质AUS EKTOPARASITENSPEICHEL SOWIEGERÄTZUM SAMMELN SOLCHER蛋白
公开(公告)号：EP0939642A4
公开(公告)日：2003-06-18
申请号：EP97920304
申请日：1997-04-10
申请人： HESKA CORP
发明人： HUNTER SHIRLEY WU , SIM GEK-KEE , WEBER ERIC R
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K35/64 , A61K38/00 , A61K39/00 , A61K39/35 , A61K48/00 , A61K49/00 , A61P17/00 , A61P29/00 , A61P37/00 , A61P37/08 , C07K14/435 , C07K16/18 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N1/02 , G01N1/24 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/04 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： G01N1/24 , A61K38/00 , A61K39/00 , C07K14/43563 , C07K14/4359 , C07K16/18
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