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公开(公告)号：EP1766052A4
公开(公告)日：2009-12-16
申请号：EP04754188
申请日：2004-06-03
发明人： BHAT BALKRISHEN , SWAYZE ERIC , ALLERSON CHARLES , DANDE PRASAD , PRAKASH THAZHA P , GRIFFEY RICHARD H
CPC分类号： C12N15/113 , A61K31/07 , C07H21/04 , C12N15/111 , C12N2310/14 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2320/51 , C12N2310/3521
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公开(公告)号：EP1127312A4
公开(公告)日：2004-09-08
申请号：EP99921921
申请日：1999-05-12
发明人： GRIFFEY RICHARD , SWAYZE ERIC
摘要： Methods for the computer-generation of virtual libraries of compounds are disclosed, including methods for tracking the addition of fragments, use of reagents, and the transformations performed. A tracking table is generated for sample compound C1 and includes entries: (a) listing the order of fragments used, and (b) listing the transformations performed for each synthesis path.
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公开(公告)号：EP1633307A4
公开(公告)日：2009-06-24
申请号：EP04754158
申请日：2004-06-03
IPC分类号： C07H21/04 , A61K20060101 , A61K48/00 , C12N15/00 , C12N15/113
CPC分类号： C12N15/1135 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322
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4.发明公开
公开(公告)号：EP1083980A4
公开(公告)日：2004-01-07
申请号：EP99924185
申请日：1999-05-12
发明人： ECKER DAVID J , GRIFFEY RICHARD , CROOKE STANELY T , SAMPATH RANGA , SWAYZE ERIC , MOHAN VENKATRAMAN , HOFSTADLER STEVEN , MCNEIL JOHN
IPC分类号： G01N31/00 , A61K45/00 , A61P43/00 , B01J19/00 , C07B61/00 , C07K1/04 , C12N15/10 , C12N15/113 , C12P19/30 , C12Q1/68 , C40B20/00 , C40B30/00 , C40B30/02 , C40B40/02 , C40B50/02 , C40B50/06 , C40B60/14 , G01N33/53 , G01N33/566 , G01N33/68 , G06F17/30 , G06F17/50 , C12N15/11 , C12P19/34 , G01N33/543 , G06F15/18
CPC分类号： G01N33/6848 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00313 , B01J2219/00351 , B01J2219/00585 , B01J2219/0059 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , C07K1/047 , C12N15/1048 , C12N15/113 , C12Q1/6811 , C40B60/14 , G01N33/68 , G01N33/6851
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5.发明公开DOUBLE STRANDED COMPOSITIONS COMPRISING A 3'-ENDO MODIFIED STRAND FOR USE IN GENE MODULATION 审中-公开具有使用在该基因调制3'-ENDO-MODIFIED STRAND双链COMPOSITIONS
公开(公告)号：EP1644475A4
公开(公告)日：2009-06-03
申请号：EP04754155
申请日：2004-06-03
IPC分类号： C07H21/04 , C12N20060101 , C12N15/11 , C12N15/113
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2320/51
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6.发明公开GENERATION OF COMBINATORIAL LIBRARIES OF COMPOUNDS CORRESPONDING TO VIRTUAL LIBRARIES OF COMPOUNDS 审中-公开CREATING化合物的组合库合规性化合物的虚拟图书馆
公开(公告)号：EP1077993A4
公开(公告)日：2004-09-08
申请号：EP99922956
申请日：1999-05-12
发明人： GRIFFEY RICHARD , SWAYZE ERIC
IPC分类号： G01N33/566 , B01J19/00 , C07B61/00 , C07K1/04 , C12N15/10 , C12Q1/00 , C40B30/02 , C40B40/02 , C40B50/00 , C40B50/02 , C40B50/06 , C40B60/14 , G01N33/68
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00313 , B01J2219/00351 , B01J2219/00585 , B01J2219/0059 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , C12N15/1048 , C40B60/14 , G01N33/68
摘要： The present invention provides methods for the generation of virtual libraries of compounds and using these libraries to build combinatorial libraries. The virtual compounds are generated in silico. The present invention encompasses methods for tracking the addition of fragments, use of reagents, and transformations performed. Further, methods for interfacing the information necessary to generate libraries of compounds with instrumentation that conducts the actual synthesis of the compounds are provided.
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公开(公告)号：EP1765074A4
公开(公告)日：2009-08-12
申请号：EP04754153
申请日：2004-06-03
发明人： BHAT BALKRISHEN , SWAYZE ERIC , PRAKASH THAZHA P , ALLERSON CHARLES , DANDE PRASAD , GRIFFEY RICHARD H
IPC分类号： C07H21/04 , A01N43/04 , C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2320/50 , C12Y301/03048 , C12N2310/3525 , C12N2310/3521
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公开(公告)号：EP1305028A4
公开(公告)日：2004-01-21
申请号：EP01959380
申请日：2001-08-01
IPC分类号： C07D233/50 , A61K31/341 , A61K31/40 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/455 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/513 , A61K31/52 , A61K31/522 , A61P31/04 , C07C237/42 , C07D213/82 , C07D239/47 , C07D239/54 , C07D241/44 , C07D307/68 , C07D333/38 , C07D333/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/18 , C07D473/34 , A61K31/54 , A61K31/18 , A61K31/34 , A61K31/35 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , C07C233/00 , C07C235/00 , C07D207/00 , C07D211/00
CPC分类号： C07D213/82 , C07D241/44 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/18 , C07D473/34
摘要： Provided are antibacterial compounds having Formula (I) wherein X is CH, O, S, N or NH; Y is CH or N; n is 0 or 1; one of R1 and R1' is -C(O)NR5R5', -C(O)-Q-NR5R5', -CH2NR5R5' or -S(O)2NR5R5' and the other is H or R3, one of R2 and R2' is -NHC(O)R6 or -NHS(O)2R6 or -NHS(O)R6 and the other is H or R4; Q is an amino acid or peptide; R3 is H, halogen, -NR5R5' or -NHC(O)R6; R4 is selected from the group consisting of H, halogen, hydroxyl, amino, carboxyl, alkyl, alkenyl and alkynyl; R5 is selected from the group consisting of H, alkyl, alkenyl or alkynyl optionally substituted with halogen, OH, amino, amidinyl, guanidinyl, urea, alkyl, carboxyl, oxo, carboxamide; R5' is H or R5 and R5' together form a 5-16 member heterocycle optionally substituted with halogen, OH, amino, alkyl, carboxyl, carbonyl or carboxamide; and R6 is selected from the group consisting of H; amino, alkyl, alkenyl or alkynyl, each optionally substituted with halogen, amino, amidinyl, guanidinyl, urea, carboxyl or carbvoxamide; a 5-16 member carbocycle or heterocycle; and a 5-16 member heterocycle-substituted alkyl or carbocycle-substituted alkyl, wherein said carbocycle and heterocycle are optionally substituted with halogen, OH, amino, alkyl, carboxyl, oxo or carboxamide.
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