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1.发明公开COMPOUNDS CO-INDUCING CHOLINERGIC UP-REGULATION AND INFLAMMATION DOWN-REGULATION AND USES THEREOF 审中-公开化合物胆碱能上调，炎性下调及其应用的复合诱导
公开(公告)号：EP1385824A2
公开(公告)日：2004-02-04
申请号：EP02712224.1
申请日：2002-02-17
IPC分类号： C07D211/60
CPC分类号： A61K31/4425 , A61K31/405 , A61K31/439 , A61K31/4439 , A61K31/455
摘要： Chimeric compounds are disclosed which are covalent conjugates of reversible or irreversible cholinergic up-regulators and non-steroidal anti-inflammatory drugs (NSAIDs), methods for their synthesis and use thereof for treatment and/or prevention of central nervous system (CNS) disorders and diseases.
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2.发明公开
公开(公告)号：EP1928560A2
公开(公告)日：2008-06-11
申请号：EP06851338.1
申请日：2006-04-06
发明人： ROBERTSON, Dan, E. , RICHARDSON, Toby , KUSTEDJO, Karen , AMITAI, Gabriel , LEJEUNE, Keith , BERBERICH, Jason , CHAPLIN, Jennifer, Ann , SINCLAIR, Jessica
IPC分类号： A62D3/02 , A62D101/04
CPC分类号： A62D3/02 , A62D2101/02 , C12N9/00 , C12N9/16
摘要： The invention provides novel enzymes and methods for enzyme-based active decontamination, e.g., nerve agent detoxification. In one aspect, the invention provides enzymes having non-heme chloroperoxidase (nhCPOs) activity, and methods for bleaching and degradation of lignin. The invention provides polypeptides, nucleic acids, infective vehicles, transduced or infected cells or plants and/or transgenic plants to, and methods of using them, e.g., provide self-protecting, pesticide-resistant and/or herbicide-resistant cells or plants, where in one aspect the polypeptides of the invention act to hydrolyzing P-S or P-F bonds and detoxify acetylcholinesterases or butyrylcholinesterases. In one aspect, the invention provides an enzyme mixture or composition that provides broad-spectrum, agent-specific oxidation and hydrolysis activities as well as hypohalite generation for oxidation or hydrolysis of V-agents, G-agents and H-agents and which generates oxidants such as chlorine dioxide and reactive radicals for killing of biological agents, including anthrax spores.
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