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1.发明公开COMPOUNDS CO-INDUCING CHOLINERGIC UP-REGULATION AND INFLAMMATION DOWN-REGULATION AND USES THEREOF 审中-公开化合物胆碱能上调，炎性下调及其应用的复合诱导
公开(公告)号：EP1385824A2
公开(公告)日：2004-02-04
申请号：EP02712224.1
申请日：2002-02-17
IPC分类号： C07D211/60
CPC分类号： A61K31/4425 , A61K31/405 , A61K31/439 , A61K31/4439 , A61K31/455
摘要： Chimeric compounds are disclosed which are covalent conjugates of reversible or irreversible cholinergic up-regulators and non-steroidal anti-inflammatory drugs (NSAIDs), methods for their synthesis and use thereof for treatment and/or prevention of central nervous system (CNS) disorders and diseases.
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2.发明公开AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY 失效与毒蕈碱AGONISTICHER活动ACTING AZA螺环化合物胆碱能系统
公开(公告)号：EP0711292A1
公开(公告)日：1996-05-15
申请号：EP94921036.0
申请日：1994-07-15
申请人： KOSMIN, Gerald, Emmanuel , STATE OF ISRAEL, REPRESENTED BY PRIME MINISTER'S OFFICE, ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH
CPC分类号： C07D471/10 , C07D491/10 , C07D497/10 , C07D513/10
摘要： The invention relates to spiro compounds having central and peripheral nervous system activity, for example muscarinic agonist activity, having formulae (I, II, III, IV, V, VI, VII, VIII and IX) and their pharmaceutically acceptable salts, quaternary compounds which are structurally derived from said compounds having a tertiary nitrogen atom, enantiomers and racemates, wherein ring A together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms, and the value of each of the other symbols in the formulae is defined.
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3.发明授权AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY 失效与毒蕈碱AGONISTICHER活动ACTING AZA螺环化合物胆碱能系统
公开(公告)号：EP0711292B1
公开(公告)日：2002-01-23
申请号：EP94921036.3
申请日：1994-07-15
申请人： KOSMIN, Gerald, Emmanuel , STATE OF ISRAEL, REPRESENTED BY PRIME MINISTER'S OFFICE, ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH
IPC分类号： C07D471/10 , A61K31/435 , C07D498/10 , C07D453/02 , C07D497/10 , C07D513/10
CPC分类号： C07D471/10 , C07D491/10 , C07D497/10 , C07D513/10
摘要： The invention relates to spiro compounds having central and peripheral nervous system activity, for example muscarinic agonist activity, having formulae (I, II, III, IV, V, VI, VII, VIII and IX) and their pharmaceutically acceptable salts, quaternary compounds which are structurally derived from said compounds having a tertiary nitrogen atom, enantiomers and racemates, wherein ring A together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms, and the value of each of the other symbols in the formulae is defined.
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