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公开(公告)号：EP3418275A1
公开(公告)日：2018-12-26
申请号：EP17753486.4
申请日：2017-02-16
发明人： SIM, Tae Bo , HUR, Woo Young , SONG, Chi Man , YOON, Ho Jong , CHOI, Seung Hye , CHO, Han Na , CHOI, Hwan Geun , KIM, Nam Doo , SON, Jung Beom , KO, Eun Hwa , KIM, Hyun Kyoung , CHO, Joong Heui , KANG, Seock Yong , KIM, So Young , KO, Yi Kyung , LEE, Seung Yeon , YOON, Suk Kyoon , BAE, Jae Hyun
IPC分类号： C07D333/10 , C07D409/12 , A61K31/381 , A61K31/4436
CPC分类号： A61K31/381 , A61K31/4436 , C07D333/10 , C07D409/12 , Y02P20/55
摘要： The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.
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公开(公告)号：EP4092029A1
公开(公告)日：2022-11-23
申请号：EP20913360.2
申请日：2020-07-14
发明人： SIM, Tae Bo , CHO, Han Na , CHOI, Seung Hye , HUR, Woo Young , SONG, Chi Man , LEE, Ji Hoon , LEE, Jung Yeol , PARK, Sun You , CHOI, Myeong A , JOO, Jeong Min
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
摘要： The present disclosure relates to a 7-amino-3,4-dihydropyrimidopyrimidin-2-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anti-cancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.
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公开(公告)号：EP3929195A1
公开(公告)日：2021-12-29
申请号：EP20759694.1
申请日：2020-02-17
发明人： SIM, Tae Bo , HUR, Woo Young , SONG, Chi Man , SENGUPTA, Sandip , PARK, Chan Sun , CHOI, Seung Hye , CHO, Han Na , SHIN, In Jae
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
摘要： The present disclosure relates to a pyrido[3,4-d]pyrimidin-8-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anticancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.
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4.发明授权2,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权2,7-取代THIEN [3,2-d]嘧啶化合物作为蛋白激酶抑制剂
公开(公告)号：EP2491043B1
公开(公告)日：2014-07-16
申请号：EP10825157.0
申请日：2010-10-15
发明人： SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , HAM, Young Jin , JUN, Eun Jin , LEE, Jung Hun , KIM, Hwan
IPC分类号： C07D495/04 , C07D495/02 , A61K31/505 , A61P35/00
CPC分类号： C07D495/04 , C07D519/00
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5.发明公开
公开(公告)号：EP4190331A1
公开(公告)日：2023-06-07
申请号：EP21850952.9
申请日：2021-07-30
发明人： SIM, Tae Bo , CHOI, Seung Hye , CHO, Han Na , KIM, Nam Kyoung , HUR, Woo Young , SONG, Chi Man , NAM, Ky Youb , YOON, Jeong Hyeok
IPC分类号： A61K31/4535 , A61P35/00 , A23L33/10
摘要： The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of gastrointestinal stromal tumor. The 2,3,5-substituted thiophene compound exhibits high inhibitory activity against the growth of gastrointestinal stromal tumor, and thus may be effectively used for the prevention, amelioration or treatment of gastrointestinal stromal tumor.
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6.发明公开
公开(公告)号：EP4105213A1
公开(公告)日：2022-12-21
申请号：EP20914046.6
申请日：2020-07-14
发明人： SIM, Tae Bo , PARK, Chan Sun , CHOI, Seung Hye , CHO, Han Na , SENGUPTA, Sandip , SHIN, In Jae , HUR, Woo Young , KUMAR, Jayprakash Narayan
IPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , A61P35/00
摘要： The present invention relates to a pyrido[[3,4- d ]pyrimidine derivative compound showing excellent antiproliferative efficacy against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating, or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition for cancer cells. The compound exhibits excellent inhibitory activity and antiproliferative efficacy against cancer cells, and thus the compound is useful not only for inhibiting cancer cells, but also for preventing cancer metastasis and proliferative diseases or for treating cancer.
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7.发明公开2,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权2,7-取代THIEN [3,2-d]嘧啶化合物作为蛋白激酶抑制剂
公开(公告)号：EP2491043A2
公开(公告)日：2012-08-29
申请号：EP10825157.0
申请日：2010-10-15
发明人： SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , HAM, Young Jin , JUN, Eun Jin , LEE, Jung Hun , KIM, Hwan
IPC分类号： C07D495/04 , C07D495/02 , A61K31/505 , A61P35/00
CPC分类号： C07D495/04 , C07D519/00
摘要： Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.
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8.发明公开
公开(公告)号：EP4190330A1
公开(公告)日：2023-06-07
申请号：EP21849180.1
申请日：2021-07-30
发明人： SIM, Tae Bo , CHOI, Seung Hye , CHO, Han Na , HUR, Woo Young , SONG, Chi Man , NAM, Ky Youb , YOON, Jeong Hyeok
IPC分类号： A61K31/4535 , A61P3/04 , A23L33/10
摘要： The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of mastocytosis. The 2,3,5-substituted thiophene compound has excellent inhibitory activity against the growth of mastocytosis cells and against an inflammatory response caused by mastocytosis, and thus may be effectively used for the prevention, amelioration or treatment of mastocytosis.
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9.发明授权THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES 有权噻吩并[3,2-d]嘧啶衍生物对蛋白激酶具有抑制活性
公开(公告)号：EP2528925B1
公开(公告)日：2017-07-05
申请号：EP11737323.3
申请日：2011-01-31
申请人： Hanmi Science Co., Ltd. , Korea Institute of Science and Technology , Catholic University Industry Academic Cooperation Foundation
发明人： SON, Jung Beom , JUNG, Seung Hyun , CHOI, Wha Il , JUNG, Young Hee , CHOI, Jae Yul , SONG, Ji Yeon , LEE, Kyu Hang , LEE, Jae Chul , KIM, Eun Young , AHN, Young Gil , KIM, Maeng Sup , CHOI, Hwan Geun , SIM, Tae Bo , HAM, Young Jin , PARK, Dong-sik , KIM, Hwan , KIM, Dong-Wook
IPC分类号： C07D495/04 , C07D495/14 , C07D409/14 , A61P35/00
CPC分类号： C07D495/04
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10.发明公开THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES 有权带有锁定对蛋白激酶噻吩并[3,2-D]嘧啶衍生物
公开(公告)号：EP2528925A2
公开(公告)日：2012-12-05
申请号：EP11737323.3
申请日：2011-01-31
申请人： Hanmi Science Co., Ltd. , Korea Institute of Science and Technology , Catholic University Industry Academic Cooperation
发明人： SON, Jung Beom , JUNG, Seung Hyun , CHOI, Wha Il , JUNG, Young Hee , CHOI, Jae Yul , SONG, Ji Yeon , LEE, Kyu Hang , LEE, Jae Chul , KIM, Eun Young , AHN, Young Gil , KIM, Maeng Sup , CHOI, Hwan Geun , SIM, Tae Bo , HAM, Young Jin , PARK, Dong-sik , KIM, Hwan , KIM, Dong-Wook
IPC分类号： C07D495/04 , C07D495/14 , C07D409/14 , A61P35/00
CPC分类号： C07D495/04
摘要： The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.
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