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1.发明授权THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES 有权噻吩并[3,2-d]嘧啶衍生物对蛋白激酶具有抑制活性
公开(公告)号：EP2528925B1
公开(公告)日：2017-07-05
申请号：EP11737323.3
申请日：2011-01-31
申请人： Hanmi Science Co., Ltd. , Korea Institute of Science and Technology , Catholic University Industry Academic Cooperation Foundation
发明人： SON, Jung Beom , JUNG, Seung Hyun , CHOI, Wha Il , JUNG, Young Hee , CHOI, Jae Yul , SONG, Ji Yeon , LEE, Kyu Hang , LEE, Jae Chul , KIM, Eun Young , AHN, Young Gil , KIM, Maeng Sup , CHOI, Hwan Geun , SIM, Tae Bo , HAM, Young Jin , PARK, Dong-sik , KIM, Hwan , KIM, Dong-Wook
IPC分类号： C07D495/04 , C07D495/14 , C07D409/14 , A61P35/00
CPC分类号： C07D495/04
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2.发明公开THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES 有权带有锁定对蛋白激酶噻吩并[3,2-D]嘧啶衍生物
公开(公告)号：EP2528925A2
公开(公告)日：2012-12-05
申请号：EP11737323.3
申请日：2011-01-31
申请人： Hanmi Science Co., Ltd. , Korea Institute of Science and Technology , Catholic University Industry Academic Cooperation
发明人： SON, Jung Beom , JUNG, Seung Hyun , CHOI, Wha Il , JUNG, Young Hee , CHOI, Jae Yul , SONG, Ji Yeon , LEE, Kyu Hang , LEE, Jae Chul , KIM, Eun Young , AHN, Young Gil , KIM, Maeng Sup , CHOI, Hwan Geun , SIM, Tae Bo , HAM, Young Jin , PARK, Dong-sik , KIM, Hwan , KIM, Dong-Wook
IPC分类号： C07D495/04 , C07D495/14 , C07D409/14 , A61P35/00
CPC分类号： C07D495/04
摘要： The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.
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3.发明公开BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE 审中-公开具有锁定效应蛋白激酶双环杂芳基衍生物
公开(公告)号：EP2528920A2
公开(公告)日：2012-12-05
申请号：EP11737311.8
申请日：2011-01-28
发明人： JUNG, Seung Hyun , JUNG, Young Hee , CHOI, Wha Il , SON, Jung Beom , JEON, Eun Ju , YANG, In Ho , SONG, Tae Hun , LEE, Mi Kyoung , KO, Myoung Sil , AHN, Young Gil , KIM, Maeng Sup , HAM, Young Jin , SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , PARK, Dong-sik , KIM, Hwan
IPC分类号： C07D487/04 , C07D495/04 , A61K31/519 , A61P43/00
CPC分类号： C07D495/04
摘要： The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.
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4.发明公开STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF 审中-公开作为β-淀粉样蛋白纤维形成抑制剂的STYRYLBENZOFURAN衍生物及其制备方法
公开(公告)号：EP2291364A2
公开(公告)日：2011-03-09
申请号：EP09762685.7
申请日：2009-06-12
发明人： KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
IPC分类号： C07D307/78 , A61K31/343
CPC分类号： C07D307/81 , C07D307/80
摘要： The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
摘要翻译： 本发明涉及有效抑制脑中β-淀粉样原纤维形成以用于预防或治疗退行性脑疾病的新型化合物，其制备方法，以及包含其作为活性成分的药物组合物。
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5.发明授权METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME 有权用于生产四唑甲烷硫酸盐及采用了新的连接
公开(公告)号：EP2524916B1
公开(公告)日：2014-07-23
申请号：EP11733103.3
申请日：2011-01-14
发明人： BANG, Keuk Chan , PARK, Bum Woo , CHOI, Jong Won , LEE, Jae Chul , AN, Yong Hoon , AHN, Young Gil , KIM, Maeng Sup
IPC分类号： C07D405/14 , C07D403/02 , C07D417/12 , C07D403/10 , C07D405/12
CPC分类号： C07D417/12 , C07D403/10 , C07D405/12 , C07D405/14
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6.发明公开METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME 有权用于生产四唑甲烷硫酸盐及采用了新的CONNECTION
公开(公告)号：EP2524916A2
公开(公告)日：2012-11-21
申请号：EP11733103.3
申请日：2011-01-14
发明人： BANG, Keuk Chan , PARK, Bum Woo , CHOI, Jong Won , LEE, Jae Chul , AN, Yong Hoon , AHN, Young Gil , KIM, Maeng Sup
IPC分类号： C07D405/14 , C07D403/02 , C07D417/12
CPC分类号： C07D417/12 , C07D403/10 , C07D405/12 , C07D405/14
摘要： According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.
摘要翻译： 。根据本发明，用于使用新的4-碘-4H-苯并吡喃-2- carbothionic酸S-苯并噻唑-2-基酯制备四唑甲磺酸盐酰化反应包括一种方法。 本发明的方法可以缩短反应时间，提高安全性与传统方法相比，能够以高收率制备率的高纯度四唑甲磺酸盐，而无需使用柱色谱法。
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7.发明授权QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS 有权喹啉或喹唑啉衍生物的细胞凋亡诱导作用，对细胞
公开(公告)号：EP2611797B1
公开(公告)日：2016-12-28
申请号：EP11822135.7
申请日：2011-08-31
发明人： BAE, In Hwan , BYUN, Eun Young , JU, Hae Kyoung , SONG, Ji Young , JUNG, Seung Hyun , JUN, Seung Ah , KIM, Ho Seok , JUNG, Young Hee , SHIM, Mi Yon , AHN, Young Gil , KIM, Maeng Sup
IPC分类号： C07D403/12 , C07D239/94 , A61K31/517 , A61P35/00 , C07K5/083
CPC分类号： C07K5/02 , A61K31/4709 , A61K31/495 , C07D215/42 , C07D239/94 , C07D403/12 , C07K5/0806
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8.发明公开QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS 有权喹啉或喹唑啉衍生物的细胞凋亡诱导作用，对细胞
公开(公告)号：EP2611797A2
公开(公告)日：2013-07-10
申请号：EP11822135.7
申请日：2011-08-31
发明人： BAE, In Hwan , BYUN, Eun Young , JU, Hae Kyoung , SONG, Ji Young , JUNG, Seung Hyun , JUN, Seung Ah , KIM, Ho Seok , JUNG, Young Hee , SHIM, Mi Yon , AHN, Young Gil , KIM, Maeng Sup
IPC分类号： C07D403/12 , C07D239/94 , A61K31/517 , A61P35/00
CPC分类号： C07K5/02 , A61K31/4709 , A61K31/495 , C07D215/42 , C07D239/94 , C07D403/12 , C07K5/0806
摘要： Provided is a pharmaceutical composition comprising, as an active ingredient, a quinoline or quinazoline derivative of formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof, which is effective in the prevention and treatment of a cancer, inflammation, autoimmune diseases or neurodegenerative disorders which are induced by the overexpression of inhibitor of apoptosis proteins (IAPs).
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