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公开(公告)号:EP1015098A1
公开(公告)日:2000-07-05
申请号:EP98906708.7
申请日:1998-02-25
CPC分类号: B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要: A method for casting-in-place composite and/or nonfilled structures (11) which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configurationcan be used , and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast-in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the apropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing (12) and can be used for size-based separations wherein the cast structure (11) acts as a semipermeable membrane barrier. The present invention also encompasses these structures as well as housings containing the structures.
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公开(公告)号:EP1015098B1
公开(公告)日:2002-08-14
申请号:EP98906708.7
申请日:1998-02-25
IPC分类号: B01D61/00 , B01D61/18 , B01D63/00 , B01D63/16 , B01D69/10 , B01D69/14 , B01J20/28 , B01L3/02
CPC分类号: B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要: A method for casting-in-place composite and/or nonfilled structures (11) which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configurationcan be used , and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast-in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the apropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing (12) and can be used for size-based separations wherein the cast structure (11) acts as a semipermeable membrane barrier. The present invention also encompasses these structures as well as housings containing the structures.
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