公开(公告)号：EP1753441A2

公开(公告)日：2007-02-21

申请号：EP05749169.8

申请日：2005-05-20

申请人： Merck & Co., Inc.

发明人： ANDERSON, Annaliesa, S.

IPC分类号： A61K38/00 ,  A61K39/085 ,  A61K39/02 ,  C07K1/00

CPC分类号： C07K14/31 ,  A61K39/00

摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a derivative of a full length S. aureus polypeptide. The full-length naturally occurring polypeptide is referred to herein as full length “ORF0826”. The SEQ ID NO: 1 derivative contains an alanine addition after the initial methionine. A His-tag derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.

摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽以及这些多肽的用途。 SEQ ID NO：1是全长金黄色葡萄球菌多肽的衍生物。 全长天然存在的多肽在本文中称为全长“ORF0826”。 SEQ ID NO：1衍生物在初始甲硫氨酸之后含有丙氨酸添加。 发现SEQ ID NO：1的His标签衍生物产生针对金黄色葡萄球菌的保护性免疫应答。

公开(公告)号：EP1791978A2

公开(公告)日：2007-06-06

申请号：EP05798108.6

申请日：2005-09-13

申请人： Merck & Co., Inc.

发明人： ANDERSON, Annaliesa, S. ,  MONTGOMERY, Donna, L.

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/02 ,  C12N15/00

CPC分类号： C07K14/31 ,  A61K39/00

摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. aureus polypeptide. The full-length polypeptide is referred to herein as full-length penicillin-binding protein 4 (“PBP4”). A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.

摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽以及这些多肽的用途。 SEQ ID NO：1是全长金黄色葡萄球菌多肽的截短衍生物。 全长多肽在本文中称为全长青霉素结合蛋白4（“PBP4”）。 发现SEQ ID NO：1的His-标记的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。

公开(公告)号：EP1784212A2

公开(公告)日：2007-05-16

申请号：EP05858353.5

申请日：2005-07-01

申请人： Merck & Co., Inc.

发明人： MONTGOMERY, Donna,I ,  JANSEN, Kathrin, Ute ,  ANDERSON, Annaliesa, S. ,  MACCLEMENTS, William, I

IPC分类号： A61K39/085

CPC分类号： A61K39/085

摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. aureus polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length “ORF2331”. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.

公开(公告)号：EP1651166B1

公开(公告)日：2010-02-17

申请号：EP04778847.6

申请日：2004-07-22

申请人： Merck & Co., Inc.

发明人： ANDERSON, Annaliesa, S. ,  JANSEN, Kathrin Ute ,  KELLY, Rosemarie ,  SCHULTZ, Loren, D. ,  MONTGOMERY, Donna, L. ,  MCCLEMENTS, William, L.

IPC分类号： A61K39/085 ,  C07K14/31 ,  C12N15/31 ,  C12N15/81

CPC分类号： A61K39/085 ,  C07K14/31 ,  C07K2319/35

公开(公告)号：EP1982185A2

公开(公告)日：2008-10-22

申请号：EP07716897.9

申请日：2007-01-23

申请人： Merck & Co., Inc.

发明人： BROWN, Martha, J. ,  ANDERSON, Annaliesa, S. ,  COPE, Leslie, D. ,  JANSEN, Kathrin, Ute ,  MCNEELY, Tessie ,  HARVEY, Barrett ,  DURR, Erberhard ,  ERNST, Robin

IPC分类号： G01N33/53 ,  C12N5/06 ,  C12N5/16

CPC分类号： C07K16/1271 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/92

摘要： The present invention features antigen binding protein that bind an ORF0657n target region (SEQ ID NO: 1). ORF0657n is an S. aureus protein. ORF0657n target regions are provided by the mAb 1G3.BD4, mAb 2H2.BE11, mAb 13C7.BC1, and mAb 13G11.BF3 binding sites. In a lethal model challenge, mAb 2H2.BE11 and mAb 13C7.BC1 provided for increased survival against S. aureus infection. There was also protection demonstrated in an ex vivo model with either the IgG1 or the IgG2b form of mAb 2H2; and in a passive immunization murine indwelling catheter model using mAb 2H2.BE11.

公开(公告)号：EP1725255A2

公开(公告)日：2006-11-29

申请号：EP05751309.5

申请日：2005-02-23

申请人： Merck & Co., Inc.

发明人： ANDERSON, Annaliesa, S. ,  CLARK, Desmond, J.

IPC分类号： A61K39/085 ,  A61K39/02 ,  A61K39/38 ,  A61K38/00 ,  A01N37/18 ,  C07K1/00

CPC分类号： C07K14/31 ,  A61K39/00

摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length S. aureus polypeptide. The full-length polypeptide is referred to herein as full length “ORF0594”. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.

公开(公告)号：EP2126070A2

公开(公告)日：2009-12-02

申请号：EP08726829.8

申请日：2008-03-14

申请人： Merck & Co., Inc.

发明人： ANDERSON, Annaliesa, S. ,  MCNEELY, Tessie ,  COOK, James, C., III ,  MCCLEMENTS, William, L. ,  MONTGOMERY, Donna, L.

IPC分类号： C12N15/00 ,  C12N1/20 ,  C12Q1/68 ,  C07K1/00 ,  C07H21/04

CPC分类号： A61K39/085

摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. epidermidis polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF2695e. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. epidermidis.

摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽以及这些多肽的用途。 SEQ ID NO：1是全长表皮葡萄球菌多肽的截短衍生物。 全长天然存在的多肽在本文中被称为全长ORF2695e。 发现SEQ ID NO：1的His-标记的衍生物产生针对表皮葡萄球菌的保护性免疫应答。

公开(公告)号：EP2117574A2

公开(公告)日：2009-11-18

申请号：EP08794276.9

申请日：2008-01-18

申请人： Merck & Co., Inc.

发明人： ANDERSON, Annaliesa, S. ,  MCNEELY, Tessie ,  COOK, James, C., III ,  MCCLEMENTS, William, L. ,  MONTGOMERY, Donna, L.

IPC分类号： A61K38/00

CPC分类号： A61K39/085 ,  A61K2039/55505

摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. epidermidis polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF1319e. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. epidermidis.

公开(公告)号：EP1791560A2

公开(公告)日：2007-06-06

申请号：EP05858114.1

申请日：2005-09-13

申请人： Merck & Co., Inc.

发明人： ANDERSON, Annaliesa, S. ,  YUAN, Jeffrey

IPC分类号： A61K39/085

CPC分类号： A61K39/085 ,  A61K2039/55505

摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length S. aureus polypeptide. The full-length polypeptide is based on full-length SA0024. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.

摘要翻译： 本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽以及这些多肽的用途。 SEQ ID NO：1是全长金黄色葡萄球菌多肽的截短衍生物。 全长多肽基于全长SA0024。 发现SEQ ID NO：1的His-标记的衍生物产生针对金黄色葡萄球菌的保护性免疫应答。

公开(公告)号：EP1651166A2

公开(公告)日：2006-05-03

申请号：EP04778847.6

申请日：2004-07-22

申请人： Merck & Co., Inc.

发明人： ANDERSON, Annaliesa, S. ,  JANSEN, Kathrin Ute ,  KELLY, Rosemarie ,  SCHULTZ, Loren, D. ,  MONTGOMERY, Donna, L. ,  MCCLEMENTS, William, L.

IPC分类号： A61K6/00

CPC分类号： A61K39/085 ,  C07K14/31 ,  C07K2319/35

摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1, uses of such polypeptides, and expression systems for producing such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length S. aureus polypeptide. The full-length polypeptide is referred to herein as full-length “ORF0657n”. Polypeptides containing the amino acid sequence of SEQ ID NO: 1 were found to produce a protective immune response against S. aureus.

摘要翻译： 本发明的特征在于包含在结构上与SEQ ID NO：1有关的氨基酸序列的多肽，这种多肽的用途以及用于产生这种多肽的表达系统。 SEQ ID NO：1是全长金黄色葡萄球菌多肽的截短衍生物。 全长多肽在本文中称为全长“ORF0657n”。 发现含有SEQ ID NO：1的氨基酸序列的多肽产生针对金黄色葡萄球菌的保护性免疫应答。