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    HETEROCYCLISCHE AMINOALKYLPYRIDINDERIVATE ALS PSYCHOPHARMAKA
    2.
    发明公开
    HETEROCYCLISCHE AMINOALKYLPYRIDINDERIVATE ALS PSYCHOPHARMAKA 有权
    杂环烯丙基氨基甲酰基吡啶二胺

    公开(公告)号：EP1292592A1

    公开(公告)日：2003-03-19

    申请号：EP01956484.8

    申请日：2001-06-19

    申请人： MERCK PATENT GmbH

    发明人： DORSCH, Dieter ,  BÖTTCHER, Henning ,  ARLT, Michael ,  GOTTSCHLICH, Rudolf ,  SEYFRIED, Christoph ,  BARTOSZYK, Gerd ,  HARTING, Jürgen

    IPC分类号： C07D401/12 ,  C07D417/12 ,  A61K31/4427 ,  C07D405/12 ,  C07D213/64

    CPC分类号： C07D213/64 ,  C07D213/38 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12

    摘要： The invention relates to formula (1) heterocyclic aminoalkyl pyridine derivatives, whereby R1 represents the radical of a heterocycle comprising 1 to 3 ring structures which are saturated, unsaturated or aromatic and optionally annellated with other ring structures to form a condensed ring system, and which comprise a total of 1 to 4 N-, O- and/or S-atoms, said heterocycle being optionally substituted once, twice or three times by at least one of the following groups: -A, -OR?4, -N(R4)¿2, -NO2, -CN, Hal, -COOR4, -CON(R4)2, -COR4, = O; R2 represents a phenyl group which is optionally substituted once, twice, three, four or five times by at least one of the following groups: Hal, A, -O-A, -NO¿2? or CN, or a thienyl group which is optionally substituted once or twice by at least one of the following groups: Hal, A, -O-A, -NO2, -CN or thienyl; -X- represents -O-, -S-, sulfinyl, sulfonyl, or -C(R?4)¿2-; -Y- represents -[C(R4)2]n-; -Z- represents -C(R4)2-; and n represents 1, 2, 3 or 4. The invention also relates to the compatible salts and solvates of the heterocyclic aminoalkyl pyridine derivatives and the use thereof as pharmaceuticals.

    摘要翻译： 本发明涉及式（1）杂环氨基烷基吡啶衍生物，其中R 1代表包含1至3个饱和，不饱和或芳族环结构的杂环基团，并且任选与其它环结构稠合形成稠合环体系，并且其 包含总共1至4个N-，O-和/或S-原子，所述杂环任选被至少一个以下基团取代一次，两次或三次：-A，-OR 4，-N（ R4）2，-NO2，-CN，Hal，-COOR4，-CON（R4）2，-COR4，= O; R2表示任选被至少一个下列基团取代一次，两次，三次，四次或五次的苯基：Hal，A，-O-A，-NO 2， 或CN，或任选被至少一个下列基团取代一次或两次的噻吩基：Hal，A，-O-A，-NO 2，-CN或噻吩基; -X-表示-O - ， - S-，亚磺酰基，磺酰基或-C（R 4）2 - -Y-代表 - [C（R4）2] n-; -Z-代表-C（R4）2-; 并且n代表1,2,3或4.本发明还涉及杂环氨基烷基吡啶衍生物的相容性盐和溶剂化物及其作为药物的用途。

    HETEROCYCLISCHE AMINOALKYLPYRIDINDERIVATE ALS PSYCHOPHARMAKA
    9.
    发明授权
    HETEROCYCLISCHE AMINOALKYLPYRIDINDERIVATE ALS PSYCHOPHARMAKA 有权
    杂环AMINOALKYLPYRIDINDERIVATE AS药物

    公开(公告)号：EP1292592B1

    公开(公告)日：2011-04-20

    申请号：EP01956484.8

    申请日：2001-06-19

    申请人： Merck Patent GmbH

    发明人： DORSCH, Dieter ,  BÖTTCHER, Henning ,  ARLT, Michael ,  GOTTSCHLICH, Rudolf ,  SEYFRIED, Christoph ,  BARTOSZYK, Gerd ,  HARTING, Jürgen

    IPC分类号： C07D401/12 ,  C07D417/12 ,  A61K31/4427 ,  C07D405/12 ,  C07D213/64

    CPC分类号： C07D213/64 ,  C07D213/38 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12

    摘要： The invention relates to formula (1) heterocyclic aminoalkyl pyridine derivatives, whereby R1 represents the radical of a heterocycle comprising 1 to 3 ring structures which are saturated, unsaturated or aromatic and optionally annellated with other ring structures to form a condensed ring system, and which comprise a total of 1 to 4 N-, O- and/or S-atoms, said heterocycle being optionally substituted once, twice or three times by at least one of the following groups: -A, -OR?4, -N(R4)¿2, -NO2, -CN, Hal, -COOR4, -CON(R4)2, -COR4, = O; R2 represents a phenyl group which is optionally substituted once, twice, three, four or five times by at least one of the following groups: Hal, A, -O-A, -NO¿2? or CN, or a thienyl group which is optionally substituted once or twice by at least one of the following groups: Hal, A, -O-A, -NO2, -CN or thienyl; -X- represents -O-, -S-, sulfinyl, sulfonyl, or -C(R?4)¿2-; -Y- represents -[C(R4)2]n-; -Z- represents -C(R4)2-; and n represents 1, 2, 3 or 4. The invention also relates to the compatible salts and solvates of the heterocyclic aminoalkyl pyridine derivatives and the use thereof as pharmaceuticals.