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公开(公告)号：EP3197451A1
公开(公告)日：2017-08-02
申请号：EP15843799.6
申请日：2015-09-23
发明人： CAI, Jiaqiang , CRESPO, Alejandro , DU, Xiaoxing , DUBOIS, Byron Gabriel , LIU, Ping , LIU, Rongqiang , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： A61K31/4355
CPC分类号： C07D491/048 , A61P7/06 , A61P9/10
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物或其药学上可接受的盐，它们用于增强促红细胞生成素的内源性产生，以及用于治疗与促红细胞生成素内源性产生减少有关的病症，例如贫血等疾病，以及 包含这种化合物和药物载体的药物组合物。
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公开(公告)号：EP3197455A1
公开(公告)日：2017-08-02
申请号：EP15845304.3
申请日：2015-09-23
发明人： CAI, Jiaqiang , COLANDREA, Vincent , CRESPO, Alejandro , DEBENHAM, John , DU, Xiaoxing , GUIADEEN, Deodialsingh , LIU, Ping , LIU, Rongqiang , MADSEN-DUGGAN, Cristina, B. , MCCOY, Joshua, G. , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： A61K31/4704
CPC分类号： C07D491/052 , C07D215/56 , C07D221/22 , C07D417/06 , C07D471/04
摘要： The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物或其药学上可接受的盐，它们用于增强促红细胞生成素的内源性产生，以及用于治疗与促红细胞生成素内源性产生减少相关的疾病如贫血等疾病， 以及包含这种化合物和药物载体的药物组合物。
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公开(公告)号：EP3197452A1
公开(公告)日：2017-08-02
申请号：EP15844485.1
申请日：2015-09-23
发明人： CAI, Jiaqiang , CRESPO, Alejandro , DEBENHAM, John , DU, Xiaoxing , LIU, Ping , LIU, Rongqiang , MADSEN-DUGGAN, Cristina, B. , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： A61K31/4355
CPC分类号： C07D495/04 , A61P7/06 , C07D491/048
摘要： The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物或其药学上可接受的盐，它们用于增强促红细胞生成素的内源性产生，以及用于治疗与促红细胞生成素内源性产生减少有关的病症，例如贫血等疾病，以及 包含这种化合物和药物载体的药物组合物。
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公开(公告)号：EP3197452B1
公开(公告)日：2020-02-26
申请号：EP15844485.1
申请日：2015-09-23
发明人： CAI, Jiaqiang , CRESPO, Alejandro , DEBENHAM, John , DU, Xiaoxing , LIU, Ping , LIU, Rongqiang , MADSEN-DUGGAN, Cristina, B. , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： C07D491/048 , C07D495/04 , A61K31/4355 , A61P7/06
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公开(公告)号：EP3197900B1
公开(公告)日：2020-02-12
申请号：EP15843683.2
申请日：2015-09-23
发明人： CAI, Jiaqiang , CRESPO, Alejandro , DU, Xiaoxing , DUBOIS, Byron Gabriel , GUIADEEN, Deodialsingh , KOTHANDARAMAN, Shankaran , LIU, Ping , LIU, Rongqiang , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： C07D471/04 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04 , C07D513/06 , A61K31/497 , A61P7/06
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公开(公告)号：EP2871957A1
公开(公告)日：2015-05-20
申请号：EP13817154.1
申请日：2013-07-10
发明人： REGER, Thomas , WALJI, Abbas , SANDERS, John , WAI, John , WANG, Liping
CPC分类号： C07D498/18 , A61K31/427 , A61K31/55 , A61K31/553 , A61K45/06 , C07D487/18 , C07D515/18 , A61K31/513 , A61K2300/00
摘要： The present invention relates to Macrocyclic Compounds. The present invention also relates to compositions comprising at least one Macrocyclic Compound, and methods of using the Macrocyclic Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：EP2276756B9
公开(公告)日：2012-08-15
申请号：EP09726601.9
申请日：2009-04-02
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HA, Sookhee, Nicole , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-Ming , WANG, Liping , ZHU, Cheng
IPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D487/04 , A61P13/00 , A61K31/4178 , A61K31/506
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
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8.发明授权HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS 有权羟基甲基ALSβ3肾上腺素能REZEPTORAGONISTEN
公开(公告)号：EP2276756B1
公开(公告)日：2011-11-30
申请号：EP09726601.9
申请日：2009-04-02
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HA, Sookhee, Nicole , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-Ming , WANG, Liping , ZHU, Cheng
IPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D487/04 , A61P13/00 , A61K31/4178 , A61K31/506
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
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公开(公告)号：EP3197900A1
公开(公告)日：2017-08-02
申请号：EP15843683.2
申请日：2015-09-23
发明人： CAI, Jiaqiang , CRESPO, Alejandro , DU, Xiaoxing , DUBOIS, Byron Gabriel , GUIADEEN, Deodialsingh , KOTHANDARAMAN, Shankaran , LIU, Ping , LIU, Rongqiang , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： C07D498/06
CPC分类号： C07D513/06 , C07D471/04 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP2274296B1
公开(公告)日：2012-10-17
申请号：EP09726940.1
申请日：2009-03-23
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HARPER, Bart , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-ming , WANG, Liping , WENDT, Harvey , ZHU, Cheng
IPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/4406 , A61P13/10
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D495/04
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