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公开(公告)号：EP3291817B1
公开(公告)日：2019-10-02
申请号：EP16789873.3
申请日：2016-05-02
IPC分类号： A61K31/513 , C07D403/04 , C07D239/36
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2.发明公开
公开(公告)号：EP3302484A1
公开(公告)日：2018-04-11
申请号：EP16804001.2
申请日：2016-05-24
发明人： SHEN, Dong-Ming , DWYER, Michael, P. , SINZ, Christopher, J. , WANG, Deping , STACHEL, Shawn, J. , PAONE, Daniel, V. , FORSTER, Ashley , BERGER, Richard , SHIPE, William, D. , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei , FU, Jianmin , GUO, Zhigang , LI, Haitang , BO, Yingjian
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28
摘要： The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：EP2568812A1
公开(公告)日：2013-03-20
申请号：EP11781053.1
申请日：2011-05-06
发明人： HALE, Jeffrey, J. , JIANG, Jinlong , SHEN, Dong-Ming , SHI, Zhi-Cai , SHU, Min , WU, Zhicai , YANG, Cangming
IPC分类号： A01N43/56 , A61K31/415
CPC分类号： C07D401/04 , C07D401/14
摘要： Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
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公开(公告)号：EP2470021A1
公开(公告)日：2012-07-04
申请号：EP10812498.3
申请日：2010-08-17
发明人： EDMONDSON, Scott, D. , BERGER, Richard , CHANG, Lehua , COLANDREA, Vincent, J. , HALE, Jeffrey, J. , HARPER, Bart , KAR, Nam Fung , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Christopher, R. , SHA, Deyou , SHEN, Dong-Ming , WANG, Liping , WENDT, Harvey, R. , ZHU, Cheng
CPC分类号： C07D403/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/147 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D498/04 , C07D513/04 , C07D513/20
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
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公开(公告)号：EP2571855B1
公开(公告)日：2014-12-24
申请号：EP11783980.3
申请日：2011-05-12
发明人： DEBENHAM, John, S. , SHEN, Dong-Ming , GRAHAM, Thomas, H. , CLEMENTS, Matthew, J. , ZHANG, Yong
IPC分类号： C07D235/02
CPC分类号： C07C237/24 , A61K31/165 , A61K31/397 , A61K31/40 , A61K31/4164 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K45/06 , C07C271/24 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/85 , C07D233/56 , C07D233/61 , C07D239/26 , C07D241/12 , C07D295/15 , C07D295/155
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公开(公告)号：EP2276756B9
公开(公告)日：2012-08-15
申请号：EP09726601.9
申请日：2009-04-02
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HA, Sookhee, Nicole , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-Ming , WANG, Liping , ZHU, Cheng
IPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D487/04 , A61P13/00 , A61K31/4178 , A61K31/506
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
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公开(公告)号：EP2470012A1
公开(公告)日：2012-07-04
申请号：EP10812548.5
申请日：2010-08-24
发明人： EDMONDSON, Scott, D. , CHANG, Lehua , KAR, Nam Fung , MORRIELLO, Gregori, J. , MOYES, Christopher, J. , SHEN, Dong-Ming , ZHU, Cheng , ANTHONY, Neville, J. , JONES, Philip , SMITH, Graham, F. , SCOTT, Mark, E. , THOMPSON, Christopher, F. , JUNG, Joon , CAMMARANO, Carolyn , HOFFMAN, Dawn Marie
IPC分类号： A01N43/38
CPC分类号： C07D401/12 , C07D207/08 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
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8.发明授权HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS 有权羟基甲基ALSβ3肾上腺素能REZEPTORAGONISTEN
公开(公告)号：EP2276756B1
公开(公告)日：2011-11-30
申请号：EP09726601.9
申请日：2009-04-02
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HA, Sookhee, Nicole , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-Ming , WANG, Liping , ZHU, Cheng
IPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D487/04 , A61P13/00 , A61K31/4178 , A61K31/506
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
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公开(公告)号：EP3500556A1
公开(公告)日：2019-06-26
申请号：EP17758764.9
申请日：2017-08-21
发明人： SHEN, Dong-Ming , KUANG, Rongze , KUMAR, Puneet , DUFFY, Joseph, L. , ZHU, Cheng , ALI, Amjad , YANG, Meng , DEBENHAM, John, S.
IPC分类号： C07D213/89 , A61K31/4425 , A61P7/02
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公开(公告)号：EP3302486A1
公开(公告)日：2018-04-11
申请号：EP16804194.5
申请日：2016-05-31
发明人： SHEN, Dong-Ming , DWYER, Michael P. , SINZ, Christopher J. , WANG, Deping , STACHEL, Shawn , PAONE, Daniel V. , FORSTER, Ashley , BERGER, Richard , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
摘要： The present invention is directed to dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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