公开(公告)号：EP2278997B1

公开(公告)日：2016-08-10

申请号：EP09734640.7

申请日：2009-04-21

申请人： Nanobio Corporation

发明人： BAKER, James, R. ,  HAMOUDA, Tarek ,  SUTCLIFFE, Joyce, A.

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61L2/00

CPC分类号： A61K39/145 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/1075 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/58 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16234 ,  C12N2760/16271

公开(公告)号：EP1633322A2

公开(公告)日：2006-03-15

申请号：EP04809431.2

申请日：2004-06-03

申请人： Nanobio Corporation

发明人： BAKER, James, R. ,  ANNIS, Ted, C. ,  HAMOUDA, Tarek

IPC分类号： A61K9/00

CPC分类号： A61K31/7048 ,  A61K9/1075

摘要： Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.

摘要翻译： 纳米乳液组合物具有低毒性没表现出微生物或预防疾病的广谱失活中描述。 所述纳米乳剂包含在wässrige相到油相，其包含油和有机溶剂的，和一种或多种表面活性剂。 因此，提供制备纳米乳剂和灭活病原微生物的方法。

公开(公告)号：EP3023107A1

公开(公告)日：2016-05-25

申请号：EP15182207.9

申请日：2009-04-21

申请人： Nanobio Corporation

发明人： BAKER, James R. ,  HAMOUDA, Tarek ,  SUTCLIFFE, Joyce A.

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61L2/00

CPC分类号： A61K39/145 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/1075 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/58 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16234 ,  C12N2760/16271

摘要： The present invention relates to methods for including an immune response to influenza in a subject comprising administering a nanoemulsion vaccine composition comprising an influenza immunogen or protein.

摘要翻译： 本发明涉及在受试者中包括对流感的免疫应答的方法，包括施用包含流感免疫原或蛋白质的纳米乳剂疫苗组合物。

公开(公告)号：EP2753354A1

公开(公告)日：2014-07-16

申请号：EP12829559.9

申请日：2012-09-10

申请人： Nanobio Corporation

发明人： HAMOUDA, Tarek ,  FATTOM, Ali, I. ,  BAKER, James, R. , 

IPC分类号： A61K39/155

CPC分类号： A61K39/155 ,  A61K9/1075 ,  A61K39/12 ,  A61K47/10 ,  A61K47/186 ,  A61K47/26 ,  A61K47/44 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N2760/18034

摘要： The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.

公开(公告)号：EP2349209A2

公开(公告)日：2011-08-03

申请号：EP09793025.9

申请日：2009-09-25

申请人： Nanobio Corporation

发明人： BAKER, James, R., Jr. ,  HAMOUDA, Tarek ,  SUTCLIFFE, Joyce, A.

IPC分类号： A61K9/107 ,  A61P11/00

CPC分类号： A61K31/198 ,  A61K9/1075 ,  A61K31/045 ,  A61K31/047 ,  A61K31/14 ,  A61K31/341 ,  A61K31/4425 ,  A61K45/06

摘要： The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

公开(公告)号：EP3488863A1

公开(公告)日：2019-05-29

申请号：EP18192928.2

申请日：2012-09-10

申请人： Nanobio Corporation

发明人： BITKO, Vira ,  HAMOUDA, Tarek ,  FATTOM, Ali, I. ,  BAKER, James, R.

IPC分类号： A61K39/155 ,  A61K47/10 ,  A61K47/26 ,  A61K47/44 ,  A61K47/18 ,  A61K9/107 ,  A61K39/00 ,  A61K39/12

摘要： The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion (F) and Glycoprotein (G) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.

公开(公告)号：EP2729169A1

公开(公告)日：2014-05-14

申请号：EP12735418.1

申请日：2012-07-06

申请人： Nanobio Corporation ,  Hamouda, Tarek ,  Bitko, Vira

发明人： HAMOUDA, Tarek ,  BITKO, Vira ,  FATTOM, Ali, I. ,  LUKACS, Nicolas ,  BAKER, James, R.

IPC分类号： A61K39/155 ,  B82Y99/00

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/1075 ,  A61K9/1271 ,  A61K9/5115 ,  A61K31/716 ,  A61K31/722 ,  A61K47/26 ,  A61K47/38 ,  A61K47/44 ,  A61K2039/5252 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55583 ,  C07K16/1027 ,  C07K2317/33 ,  C07K2317/76 ,  C12N7/00 ,  C12N2760/18521 ,  C12N2760/18522 ,  C12N2760/18534 ,  A61K2300/00

摘要： The present invention relates to RSV vaccines and methods for inducing an immune response to RSV in a subject comprising administering an RSV vaccine.

摘要翻译： 本发明涉及RSV疫苗和在受试者中诱导针对RSV的免疫应答的方法，包括施用RSV疫苗。

公开(公告)号：EP2588135A2

公开(公告)日：2013-05-08

申请号：EP11801436.4

申请日：2011-06-30

申请人： The Regents of The University of Michigan ,  Nanobio Corporation

发明人： BAKER, Jr., James R. ,  HAMOUDA, Tarek ,  CIOTTI, Susan M.

IPC分类号： A61K39/145 ,  A61K47/48 ,  A61K9/10 ,  A61K9/107 ,  A61P31/00

CPC分类号： A61K9/1075 ,  A61K39/39 ,  A61K2039/55566 ,  C12N2760/16134 ,  Y02A50/394 ,  Y02A50/403 ,  Y02A50/469

摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more immunogens within the oil phase of the nanoemulsion and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the invention find use in, among other things, clinical (e.g., therapeutic and preventative medicine (e.g., vaccination)) and research applications.

公开(公告)号：EP2280690A2

公开(公告)日：2011-02-09

申请号：EP09732999.9

申请日：2009-04-17

申请人： Nanobio Corporation

发明人： FLACK, Mary, R. ,  CIOTTI, Marie ,  HAMOUDA, Tarek ,  SUTCLIFFE, Joyce, A. ,  BAKER, James, R.

IPC分类号： A61K9/107

CPC分类号： A61K9/1075 ,  A61K9/0014

摘要： The present invention relates to methods for treating, killing, and/or inhibiting the growth of Herpes viruses in human subjects comprising topically administering to a human subject in need thereof a nanoemulsion composition having antiviral properties.

摘要翻译： 本发明涉及用于治疗，杀死和/或抑制人类受试者中疱疹病毒生长的方法，其包括向有需要的人受试者局部施用具有抗病毒性质的纳米乳剂组合物。

公开(公告)号：EP2278997A1

公开(公告)日：2011-02-02

申请号：EP09734640.7

申请日：2009-04-21

申请人： Nanobio Corporation

发明人： BAKER, James, R. ,  HAMOUDA, Tarek ,  SUTCLIFFE, Joyce, A.

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61L2/00

CPC分类号： A61K39/145 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/1075 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/58 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16234 ,  C12N2760/16271

摘要： The present invention relates to methods for inducing an immune response to influenza in a subject comprising administering a nanoemulsion vaccine composition comprising an influenza immunogen or protein.