公开(公告)号：EP0794788B1

公开(公告)日：2003-05-14

申请号：EP95943691.6

申请日：1995-12-06

申请人： NEORX CORPORATION

发明人： THEODORE, Louis J. ,  AXWORTHY, Donald B. ,  RENO, John M.

IPC分类号： A61K31/715 ,  A61K38/14 ,  A61K51/06 ,  C07H15/02 ,  C07K9/00

CPC分类号： B82Y5/00 ,  A61K47/6893 ,  A61K51/0465 ,  A61K2121/00 ,  C07H15/04 ,  C07H15/14

摘要： Hepatic-directed compounds, reagents useful in making such compounds and methods and compositions are discussed. The hepatic-directed compounds are comprised of at least three hexose residues, preferably galactose residues, and of a functional moiety capable of reacting with a binding moiety, a targeting moiety, or an active agent. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from metabolic mechanisms encountered by compounds which are not so directed. The hepatic-directed compounds are used to deliver moieties and agents to the liver and to improve targeting ratio.

公开(公告)号：EP0794788A1

公开(公告)日：1997-09-17

申请号：EP95943691.0

申请日：1995-12-06

申请人： NEORX CORPORATION

发明人： THEODORE, Louis J. ,  AXWORTHY, Donald B. ,  RENO, John M.

IPC分类号： A61K31 ,  A61K47 ,  A61K51 ,  A61P1 ,  C07H15

CPC分类号： B82Y5/00 ,  A61K47/6893 ,  A61K51/0465 ,  A61K2121/00 ,  C07H15/04 ,  C07H15/14

摘要： Hepatic-directed compounds, reagents useful in making such compounds and methods and compositions are discussed. The hepatic-directed compounds are comprised of at least three hexose residues, preferably galactose residues, and of a functional moiety capable of reacting with a binding moiety, a targeting moiety, or an active agent. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from metabolic mechanisms encountered by compounds which are not so directed. The hepatic-directed compounds are used to deliver moieties and agents to the liver and to improve targeting ratio.

公开(公告)号：EP0733066B1

公开(公告)日：2003-11-19

申请号：EP95905334.9

申请日：1994-12-07

申请人： NeoRx Corporation

发明人： THEODORE, Louis J. ,  MEYER, Damon L. ,  MALLETT, Robert W. ,  KASINA, Sudhakar ,  RENO, John M. ,  AXWORTHY, Donald B. ,  GUSTAVSON, Linda M.

IPC分类号： C07K14/52 ,  C07K14/525 ,  C07K14/53 ,  C07K14/535 ,  C07K14/54 ,  C07K14/555 ,  C07K16/00 ,  C07K16/30 ,  A61K38/17 ,  A61K38/38 ,  A61K47/48

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/557 ,  A61K47/6851 ,  A61K47/6897 ,  A61K48/00 ,  A61K51/1093 ,  A61K2039/505 ,  C07F13/005 ,  C07K14/765 ,  C07K16/30 ,  C12N15/87

摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed.

公开(公告)号：EP1138334A2

公开(公告)日：2001-10-04

申请号：EP01201994.9

申请日：1993-06-07

申请人： NEORX CORPORATION

发明人： AXWORTHY, Donald B. ,  THEODORE, Louis J. ,  GUSTAVSON, Linda M. ,  RENO, John M.

IPC分类号： A61K51/04 ,  A61K47/48

CPC分类号： C07D495/04 ,  A61K47/54 ,  A61K47/557 ,  A61K47/665 ,  A61K47/68 ,  A61K47/6887 ,  A61K47/6893 ,  A61K47/6898 ,  A61K51/0497 ,  A61K51/1268 ,  A61K2121/00 ,  A61K2123/00 ,  B82Y5/00

摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.

摘要翻译： 公开了与诊断和治疗剂的预靶向递送相关的方法，化合物，组合物和试剂盒。 特别地，描述了用于生物素的放射性金属标记和改善生物素的放射性卤化的方法以及相关化合物。 此外，讨论了清除剂，抗配体靶向部分缀合物，靶细胞保留增强部分和另外的方法。

公开(公告)号：EP0799050B1

公开(公告)日：2004-08-11

申请号：EP95942562.0

申请日：1995-12-06

申请人： NEORX CORPORATION

发明人： THEODORE, Louis J. ,  KASINA, Sudhakar ,  RENO, John M.

IPC分类号： A61K51/08 ,  C07K14/47

CPC分类号： A61K51/088 ,  A61K47/547 ,  A61K51/0478 ,  A61K51/087

摘要： Radiolabeled annexin-galactose cluster conjugates useful for imaging vascular thrombi are discussed. Methods for making such radiolabeled annexin-galactose cluster conjugates are also addressed.

公开(公告)号：EP0799050A1

公开(公告)日：1997-10-08

申请号：EP95942562.0

申请日：1995-12-06

申请人： NEORX CORPORATION

发明人： THEODORE, Louis J. ,  KASINA, Sudhakar ,  RENO, John M.

IPC分类号： A61K51

CPC分类号： A61K51/088 ,  A61K47/547 ,  A61K51/0478 ,  A61K51/087

摘要： Radiolabeled annexin-galactose cluster conjugates useful for imaging vascular thrombi are discussed. Methods for making such radiolabeled annexin-galactose cluster conjugates are also addressed.

公开(公告)号：EP0733066A1

公开(公告)日：1996-09-25

申请号：EP95905334.0

申请日：1994-12-07

申请人： NEORX CORPORATION

发明人： THEODORE, Louis J. ,  MEYER, Damon L. ,  MALLETT, Robert W. ,  KASINA, Sudhakar ,  RENO, John M. ,  AXWORTHY, Donald B. ,  GUSTAVSON, Linda M.

IPC分类号： G01N33 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K47 ,  A61K48 ,  A61K49 ,  A61K51 ,  A61P3 ,  A61P7 ,  A61P9 ,  A61P25 ,  A61P27 ,  A61P29 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07D495 ,  C07F13 ,  C07K14 ,  C07K16 ,  C12N15

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K47/557 ,  A61K47/6851 ,  A61K47/6897 ,  A61K48/00 ,  A61K51/1093 ,  A61K2039/505 ,  C07F13/005 ,  C07K14/765 ,  C07K16/30 ,  C12N15/87

摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed.

公开(公告)号：EP0732943A1

公开(公告)日：1996-09-25

申请号：EP95907933.0

申请日：1994-11-23

申请人： NEORX CORPORATION

发明人： THEODORE, Louis J. ,  RENO, John M. ,  GUSTAVSON, Linda M.

IPC分类号： C07H13 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K47 ,  A61K48 ,  A61K51 ,  A61P35

CPC分类号： B82Y5/00 ,  A61K47/54 ,  A61K47/557 ,  A61K47/665 ,  A61K47/6887 ,  A61K47/6893 ,  A61K47/6897 ,  A61K47/6898 ,  A61K51/0497 ,  A61K51/1268 ,  A61K2121/00 ,  A61K2123/00

摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, three-step pretargeting methods are described.