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公开(公告)号：EP0733066B1
公开(公告)日：2003-11-19
申请号：EP95905334.9
申请日：1994-12-07
申请人： NeoRx Corporation
发明人： THEODORE, Louis J. , MEYER, Damon L. , MALLETT, Robert W. , KASINA, Sudhakar , RENO, John M. , AXWORTHY, Donald B. , GUSTAVSON, Linda M.
IPC分类号： C07K14/52 , C07K14/525 , C07K14/53 , C07K14/535 , C07K14/54 , C07K14/555 , C07K16/00 , C07K16/30 , A61K38/17 , A61K38/38 , A61K47/48
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/557 , A61K47/6851 , A61K47/6897 , A61K48/00 , A61K51/1093 , A61K2039/505 , C07F13/005 , C07K14/765 , C07K16/30 , C12N15/87
摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed.
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公开(公告)号：EP1138334A2
公开(公告)日：2001-10-04
申请号：EP01201994.9
申请日：1993-06-07
申请人： NEORX CORPORATION
CPC分类号： C07D495/04 , A61K47/54 , A61K47/557 , A61K47/665 , A61K47/68 , A61K47/6887 , A61K47/6893 , A61K47/6898 , A61K51/0497 , A61K51/1268 , A61K2121/00 , A61K2123/00 , B82Y5/00
摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.
摘要翻译： 公开了与诊断和治疗剂的预靶向递送相关的方法，化合物，组合物和试剂盒。 特别地，描述了用于生物素的放射性金属标记和改善生物素的放射性卤化的方法以及相关化合物。 此外，讨论了清除剂，抗配体靶向部分缀合物，靶细胞保留增强部分和另外的方法。
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3.发明公开S 3N CHELATING COMPOUNDS FOR THE RADIOLABELING OF LIGANDS, ANTI-LIGANDS OR OTHER PROTEINS 失效小号3N切拉动物END化合物配体的抗配体或其他蛋白质的RADIO MARK
公开(公告)号：EP0724601A1
公开(公告)日：1996-08-07
申请号：EP94925919.0
申请日：1994-08-17
申请人： NEORX CORPORATION
CPC分类号： C07D495/04 , A61K51/0478 , A61K51/1045 , A61K51/1093 , A61K2121/00 , C07B59/004 , C07D339/06 , C07F13/005 , G01N33/534
摘要： Novel chelating compounds and the corresponding radionuclide metal chelates are useful for radiolabeling proteins such as antibodies, ligands such as biotin and anti-ligands such as streptavidin with radionuclide metals such as ?99mTc, 186¿Re, and 188Re. The radiolabeled proteins, ligands and anti-ligands have diagnostic or therapeutic use, depending on the radionuclide metal chosen.
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公开(公告)号：EP0713395A1
公开(公告)日：1996-05-29
申请号：EP94923410.0
申请日：1994-07-12
申请人： NEORX CORPORATION
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/62 , A61K47/6883 , A61K47/6897 , A61K47/6898 , C07K14/36 , C07K14/465 , C07K14/47 , C07K14/473 , C07K14/721 , C07K14/723 , C07K14/76
摘要： Polymeric carriers are polypeptides comprising at least one drug-binding domain that non-covalently binds a drug. A polymeric carrier may be attached to an antibody specific for desired target cells to form immunoconjugates that deliver a drug to the target cells in vivo. A polymeric carrier may be attached to a proteinaceous or a non-proteinaceous ligand or anti-ligand to form a conjugate useful in pretargeting protocols to deliver a drug to target cells in vivo. The carriers are derived from drug-binding proteins and produced through peptide synthesis or recombinant DNA technology.
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公开(公告)号：EP0683676A1
公开(公告)日：1995-11-29
申请号：EP94909508.0
申请日：1994-01-26
申请人： NEORX CORPORATION
IPC分类号： A61K51
CPC分类号： A61K51/0497 , A61K51/065 , A61K51/083 , A61K51/088 , A61K51/1093 , A61K2121/00 , A61K2123/00
摘要： The present invention provides methods for directing the biodistribution of molecules that are not generally specifically excreted via the renal pathway to renal excretion. The methods employ conjugates or complexes containing a directed biodistribution molecule (DBM) and one or more bound molecules, wherein the biodistribution of the conjugate or complex is directed to renal excretion in vivo by the DBM component thereof.
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公开(公告)号：EP1138334A3
公开(公告)日：2002-04-03
申请号：EP01201994.9
申请日：1993-06-07
申请人： NEORX CORPORATION
IPC分类号： A61K47/48
CPC分类号： C07D495/04 , A61K47/54 , A61K47/557 , A61K47/665 , A61K47/68 , A61K47/6887 , A61K47/6893 , A61K47/6898 , A61K51/0497 , A61K51/1268 , A61K2121/00 , A61K2123/00 , B82Y5/00
摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.
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7.发明公开RADIONUCLIDE METAL CHELATES FOR THE RADIOLABELING OF LIGANDS, ANTI-LIGANDS OR OTHER PROTEINS 失效放射性核素螯合物配体抗配体或不同的蛋白RADIO MARK
公开(公告)号：EP0792170A1
公开(公告)日：1997-09-03
申请号：EP94924458.0
申请日：1994-07-12
申请人： NEORX CORPORATION
CPC分类号： C07K5/06139 , A61K51/0497 , A61K51/1054 , C07F13/005 , C07K5/0606
摘要： Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies as well as proteinaceous and non-proteinaceous ligands and anti-ligands. The radiolabeled antibodies, ligands or anti-ligands, or catabolites thereof, demonstrate improved biodistribution properties, including reduced localization within the intestines.
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公开(公告)号：EP0733066A1
公开(公告)日：1996-09-25
申请号：EP95905334.0
申请日：1994-12-07
申请人： NEORX CORPORATION
发明人： THEODORE, Louis J. , MEYER, Damon L. , MALLETT, Robert W. , KASINA, Sudhakar , RENO, John M. , AXWORTHY, Donald B. , GUSTAVSON, Linda M.
IPC分类号： G01N33 , A61K38 , A61K39 , A61K45 , A61K47 , A61K48 , A61K49 , A61K51 , A61P3 , A61P7 , A61P9 , A61P25 , A61P27 , A61P29 , A61P35 , A61P37 , A61P43 , C07D495 , C07F13 , C07K14 , C07K16 , C12N15
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/557 , A61K47/6851 , A61K47/6897 , A61K48/00 , A61K51/1093 , A61K2039/505 , C07F13/005 , C07K14/765 , C07K16/30 , C12N15/87
摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed.
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公开(公告)号：EP0732943A1
公开(公告)日：1996-09-25
申请号：EP95907933.0
申请日：1994-11-23
申请人： NEORX CORPORATION
CPC分类号： B82Y5/00 , A61K47/54 , A61K47/557 , A61K47/665 , A61K47/6887 , A61K47/6893 , A61K47/6897 , A61K47/6898 , A61K51/0497 , A61K51/1268 , A61K2121/00 , A61K2123/00
摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, three-step pretargeting methods are described.
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