公开(公告)号：EP2682134A1

公开(公告)日：2014-01-08

申请号：EP12752063.3

申请日：2012-02-28

Applicant: Tokyo Women's Medical University ,  Osaka University

Inventor： KINOOKA, Masahiro ,  SAITO, Atsuhiro ,  SAWA, Yoshiki ,  SHIMIZU, Tatsuya ,  OKANO, Teruo

IPC: A61L27/00 ,  C12M3/04

CPC classification number: A61K35/33 ,  A61K35/34 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3886 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/64 ,  A61L2430/20 ,  C12N5/0691 ,  C12N2502/1323 ,  C12N2502/1335 ,  C12N2502/28 ,  C12N2533/52

Abstract: The types and relative proportions of cells constituting a cell sheet stack, and the number of cells to be seeded are altered to change the state of the cells in the cell sheet stack, whereby production of an angiogenesis-promoting cytokine as well as construction of a vascular endothelial network can be optimized.

Abstract translation: 改变构成细胞片叠层的细胞的种类和相对比例，以及待接种的细胞数目，以改变细胞片叠层细胞的状态，从而产生促血管生成细胞因子以及 血管内皮网可以优化。

公开(公告)号：EP3998333A1

公开(公告)日：2022-05-18

申请号：EP20836408.3

申请日：2020-07-10

Applicant: Osaka University

Inventor： KINOOKA, Masahiro ,  KIM, Meehae

IPC: C12N5/071 ,  C12N5/10

Abstract: Provided is a method that is able to simply promote cell proliferation.
An aspect relates to a method for promoting proliferation of cells. The method includes adding a precursor of AGEs to a culture medium containing a cell aggregate, and culturing the cell aggregate in the culture medium to which the precursor of AGEs has been added

公开(公告)号：EP4477744A1

公开(公告)日：2024-12-18

申请号：EP23749881.1

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： KINOOKA, Masahiro ,  KIM, Meehae ,  FUJINAGA, Yukako

IPC: C12N5/071 ,  C07K14/33

Abstract: A method for producing a retinal pigment epithelial (RPE) cell, including promoting differentiation induction from a pluripotent stem cell into an RPE cell by culturing the pluripotent stem cell in a medium containing an E-cadherin inhibitor is provided by the present invention.

公开(公告)号：EP4477743A1

公开(公告)日：2024-12-18

申请号：EP23749882.9

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： KINOOKA, Masahiro ,  KIM, Meehae ,  FUJINAGA, Yukako

IPC: C12N5/02 ,  C12N5/0735 ,  C12N5/10

Abstract: The present invention provides an agent for directional control of differentiation induction of a pluripotent stem cell, comprising an E-cadherin inhibitor.

公开(公告)号：EP3715378A1

公开(公告)日：2020-09-30

申请号：EP18880123.7

申请日：2018-11-22

Applicant: National University Corporation Kanazawa University ,  Osaka University

Inventor： FUJINAGA, Yukako ,  AMATSU, Sho ,  KINOOKA, Masahiro

IPC: C07K19/00 ,  C07K14/33 ,  C12N5/071 ,  C12N15/31 ,  C12N15/62 ,  C12P21/02

Abstract: The present invention provides a miniaturized hemagglutinin complex protein having function inhibitory activity against E-cadherin, wherein
(a) all or a part of at least HA1 subcomponent, and/or a part of HA3 subcomponent are/is deleted,
(b) regions in HA2 and HA3 subcomponents that contribute to binding with E-cadherin are present, and
(c) the HA3 subcomponent is derived from Clostridium botulinum type A or type B, and an E-cadherin function inhibitor containing the hemagglutinin complex protein.