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    CELL STRUCTURE AND METHOD FOR PRODUCING CELL STRUCTURE
    5.
    发明公开
    CELL STRUCTURE AND METHOD FOR PRODUCING CELL STRUCTURE 审中-公开
    细胞结构和产生细胞结构的方法

    公开(公告)号：EP3320925A1

    公开(公告)日：2018-05-16

    申请号：EP16824394.7

    申请日：2016-07-08

    申请人： Fujifilm Corporation

    发明人： NAKAMURA Kentaro

    IPC分类号： A61L27/00 ,  A61K35/28 ,  A61K35/33 ,  A61K35/34 ,  A61K35/407 ,  A61K35/44 ,  A61P1/16 ,  A61P1/18 ,  A61P9/04 ,  A61P9/10 ,  A61P13/12 ,  A61P25/02 ,  A61P27/02 ,  C12N5/071

    CPC分类号： A61L27/3886 ,  A61K35/28 ,  A61K35/33 ,  A61K35/34 ,  A61K35/407 ,  A61K35/44 ,  A61L27/00 ,  A61L27/222

    摘要： An object of the present invention is to provide a cell structure which can be produced within a short period of time and has a predetermined or larger size, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure including: a biocompatible macromolecular block; and two or more kinds of cells, in which a plurality of the biocompatible macromolecular blocks are arranged in gaps between a plurality of the cells, and in which the two or more kinds of cells contain at least one kind of first cell selected from the group consisting of vascular endothelial cells, cardiac muscle cells, pancreatic islet cells, liver cells, epithelial cells, endothelial cells, nerve cells, embryonic stem cells, induced pluripotent stem cells, corneal epithelial cells, and retinal pigment epithelial cells, and at least one kind of second cell selected from the group consisting of mesenchymal cells, stromal cells, fibroblasts, smooth muscle cells, myoblasts, mesenchymal stem cells, adipose-derived stem cells, and umbilical cord-derived stem cells.

    摘要翻译： 本发明的目的在于提供一种能够在短时间内制造并且具有预定尺寸或更大尺寸的蜂窝结构以及用于制造上述蜂窝结构的方法。 根据本发明，提供了一种细胞结构，其包含：生物相容性高分子块; 以及多个所述生物相容性高分子块排列在多个所述细胞间的间隙中的两种以上的细胞，所述两种以上的细胞含有选自所述组中的至少一种第一细胞 由血管内皮细胞，心肌细胞，胰岛细胞，肝细胞，上皮细胞，内皮细胞，神经细胞，胚胎干细胞，诱导多能干细胞，角膜上皮细胞和视网膜色素上皮细胞组成，并且至少一种 选自间充质细胞，基质细胞，成纤维细胞，平滑肌细胞，成肌细胞，间充质干细胞，脂肪来源的干细胞和来自脐带的干细胞的第二细胞。

    METHOD OF TREATING PANCREATIC AND LIVER CONDITIONS BY TRANSPLANTATION OF STEM CELLS INTO BILE DUCT WALLS
    9.
    发明公开
    METHOD OF TREATING PANCREATIC AND LIVER CONDITIONS BY TRANSPLANTATION OF STEM CELLS INTO BILE DUCT WALLS 审中-公开
    肝胰腺和处理方法受苦BY移植干细胞瘿GANG墙

    公开(公告)号：EP2970879A4

    公开(公告)日：2016-12-28

    申请号：EP14763985

    申请日：2014-03-13

    申请人： UNIV NORTH CAROLINA CHAPEL HILL ,  UNIV MIAMI ,  SAPIENZA UNIV DI ROMA

    发明人： REID LOLA MCADAMS ,  WANG YUNFANG ,  GERBER DAVID A ,  LANZONI GIACOMO ,  INVERARDI LUCA ,  DOMINGUEZ-BENDALA JUAN ,  ALVARO DOMENICO ,  CARDINALE VINCENZO ,  GAUDIO EUGENIO ,  CARPINO GUIDO

    IPC分类号： A61L27/38 ,  A61L27/54

    CPC分类号： A61K35/407 ,  A61L27/3834 ,  A61L27/3886 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/28

    摘要： A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem cells, hepatic stem cells, pancreatic stem cells or their descendants, committed progenitor cells, from healthy tissue of the patient or of the biliary tree of a non-autologous donor and engrafting the cells into the wall of bile ducts near to the organ to be treated. The graft consists of stem cells or progenitors that are admixed with biomaterials and, optionally, with cytokines and/or native epithelial-mesenchymal cells appropriate for the maturational lineage stage of the cells to be engrafted. The cells are specifically introduced to the hepato-pancreatic common duct of the subject for treatment of pancreatic conditions or to the bile duct wall near to the liver for treatment of liver conditions and allowed to migrate to the pancreas or to the liver and expand and then rebuild part or the entirety of the diseased or dysfunctional organ.

    摘要翻译： 提供修复患病的或不正常的胰腺或肝的方法。 该方法涉及制备的悬浮液的干细胞和/或祖细胞的：如胆管树干细胞，肝干细胞，胰腺干细胞或它们的后代，定型祖细胞，从患者的健康组织或的胆管树的 非自体供体和移植的细胞分化成胆管的壁附近的器官来对待。 干细胞或祖细胞的移植物besteht没有被混有生物材料和任选地，用细胞因子和/或天然的上皮 - 间充质细胞的适当的细胞的成熟谱系阶段被嫁接。 将细胞专门介绍可用于治疗胰条件或接近至肝脏用于治疗肝脏疾病的胆管壁受试者的肝胰共同管和允许迁移到胰腺或肝和扩展，然后 重建部分或病变或功能失调器官的全部。