-
1.发明公开
公开(公告)号：EP0655992A1
公开(公告)日：1995-06-07
申请号：EP94918525.0
申请日：1994-06-15
发明人： TANAKA, Tatsuyoshi 7-10, Aza-nakase-nakanokoshi, , SAKURAI, Yohji , FUJISAWA, Nobutaka 16-7, Aza-nakase-nishinokoshi, , HONGOH, Osamu 1-10-50, Minamiokinosu , NISHI, Takao 2-28, Aza-sotobiraki, Tarohachisu
IPC分类号： C07C49 , C07C65 , C07C69 , C07C225 , C07C229 , C07C255 , C07C323 , C07D213 , C07D233 , C07D235 , C07D239 , C07D241 , C07D263 , C07D295 , C07D521
CPC分类号： C07D213/70 , C07C49/747 , C07C49/755 , C07C49/757 , C07C65/24 , C07C69/00 , C07C225/18 , C07C229/14 , C07C255/36 , C07C323/22 , C07C2601/14 , C07C2603/00 , C07C2603/18 , C07D231/12 , C07D233/56 , C07D233/84 , C07D235/28 , C07D239/42 , C07D241/20 , C07D249/08 , C07D263/14 , C07D295/116
摘要： The present invention provides novel fluorenone derivatives represented by formula (A) (wherein Ra-Rg are defined in the specification), and a method for repairing and protecting central or peripheral nerve degeneration comprising use of a fluorenone derivative represented by formula (1) (wherein R1, R2, p and q are as defined in the specification) as an active component.
摘要翻译： 本发明提供由式表示的新的芴酮衍生物（A）（R worin -R
在说明书中定义），和代表用于修复和保护中枢或外周神经变性，其包括使用芴酮衍生物的方法 由式（1）（worin - [R <1>，R <2>中，p和q如说明书中所定义）作为活性组分。 -
2.发明授权PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS 有权PIPERAZIN-SUBSTITUIERTE BENZOTHIOPHENDERIVATE ALS ANTIPSYCHOTISCHE WIRKSTOFFE
公开(公告)号：EP2753617B9
公开(公告)日：2017-01-25
申请号：EP12766485.2
申请日：2012-09-07
发明人： YAMASHITA, Hiroshi , SAKURAI, Yohji , MIYAMOTO, Motoyuki , NAKAMURA, Yuichi , KURODA, Hideaki , MINOWA, Takuya
IPC分类号： C07D409/12 , A61K31/4704 , A61P25/00
CPC分类号： A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K31/695 , C07D409/12 , C07D409/14
摘要： Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供了一种具有较好的溶解度的优异的新型杂环化合物，例如芝麻油和苯甲酸苄酯，其具有较宽的处理光谱，副作用较小，耐受性和安全性优异，且使用方便。 由式（I）表示的杂环化合物，其中每个符号如说明书中所定义，或其盐。
-
3.发明授权N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-取代的3-氨基吡咯烷化合物可用作单胺再用抑制剂
公开(公告)号：EP1881975B8
公开(公告)日：2014-04-09
申请号：EP06756356.9
申请日：2006-05-12
发明人： KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Haruhiko , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
-
4.发明授权N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-二SUBSTIUIERTE健身3-氨基吡咯烷作为MONO胺回收抑制剂的
公开(公告)号：EP1881975B1
公开(公告)日：2014-01-08
申请号：EP06756356.9
申请日：2006-05-12
发明人： KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Harukiho , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
-
公开(公告)号：EP2435046A1
公开(公告)日：2012-04-04
申请号：EP10726330.3
申请日：2010-05-27
IPC分类号： A61K31/519 , C07D471/04 , A61P25/22 , A61P25/24
CPC分类号： C07D471/04 , A61K31/519 , C07D491/048 , C07D491/056 , C07D495/04 , C07D519/00
摘要： The present invention provides a novel heterocyclic compound. A heterocyclic compound represented by general formula (1) wherein, R
1 and R
2 , each independently represent hydrogen; a phenyl lower alkyl group that may have a substituent(s) selected from the group consisting of a lower alkyl group and the like on a benzene ring and/or a lower alkyl group; or a cyclo C3-C8 alkyl lower alkyl group; or the like; R
3 represents a lower alkynyl group or the like; R
4 represents a phenyl group that may have a substituent(s) selected from the group consisting of a 1,3,4-oxadiazolyl group that may have e.g., halogen or a heterocyclic group selected from pyridyl group and the like; the heterocyclic group may have at least one substituent(s) selected from a lower alkoxy group and the like or a salt thereof.-
6.发明公开N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS 有权N，N-二SUBSTIUIERTE健身3-氨基吡咯烷作为MONO胺回收抑制剂的
公开(公告)号：EP1881975A1
公开(公告)日：2008-01-30
申请号：EP06756356.9
申请日：2006-05-12
发明人： KURIMURA, Muneaki , TAIRA, Shinichi , TOMOYASU, Takahiro , ITO, Nobuaki , TAI, Kuninori , TAKEMURA, Noriaki , MATSUZAKI, Takayuki , MENJO, Yasuhiro , MIYAMURA, Shin , SAKURAI, Yohji , WATANABE, Akihito , SAKATA, Yasuyo , MASUMOTO, Takumi , AKAZAWA, Kohei , SUGINO, Harukiho , AMADA, Naoki , OHASHI, Satoshi , SHINOHARA, Tomoichi , SASAKI, Hirofumi , MORITA, Chisako , YAMASHITA, Junko , NAKAJIMA, Satoko
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D207/14 , C07D405/12 , C07D407/12 , A61K31/497 , A61K31/4439 , A61K31/40 , A61P25/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D407/14
CPC分类号： C07D205/04 , C07D207/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F7/10
摘要： The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.
-
公开(公告)号：EP0666840A1
公开(公告)日：1995-08-16
申请号：EP94922362.0
申请日：1994-08-11
发明人： SAKURAI, Yohji , KURAHASHI, Nobuyuki , HIROSE, Tsuyoshi , MIWA, Takashi , MORI, Atsushi , NISHI, Takao
IPC分类号： C07C217
CPC分类号： C07C217/58 , C07C2601/02 , C07C2601/04 , C07C2601/14
摘要： An object of the present invention is to provide a benzylamine derivative or salt thereof having anti-depressant and antianxiety activities. The benzylamine derivative according to the present invention is represented by general formula (I), wherein R1 is a lower alkyl group; R2 is a cycloalkyl group; and R3 is a halogen atom.
摘要翻译： PCT No.PCT / JP94 / 01332 Sec。 371日期：1995年4月28日 102（e）1995年4月28日PCT PCT 1994年8月11日PCT公布。 出版物WO95 / 06630 日期：1995年3月9日具有抗抑郁和抗焦虑活性的苄胺衍生物或其盐具有以下通式：其中R 1为低级烷基; R2是环烷基; 并且R 3是卤素原子; 或其盐。
-
公开(公告)号：EP3022199A1
公开(公告)日：2016-05-25
申请号：EP14748306.9
申请日：2014-07-16
发明人： SATO, Seiji , MATSUDA, Satoshi , MATSUMURA, Chiharu , ITOTANI, Motohiro , SHINOHARA, Toshio , FUJITA, Shigekazu , SAKURAI, Yohji , TAI, Kuninori , FUKUSHIMA, Tae , KANEMOTO, Naohide , OKAMOTO, Takashi
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D411/12 , C07D411/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D249/04 , C07D249/06 , A61K31/4192
CPC分类号： C07D249/06 , C07D249/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D409/12 , C07D409/14 , C07D411/12 , C07D411/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07F9/5456
摘要： This invention relates to a cyanotriazole compound represented by the formula (1): wherein each symbols are defined in the specification, or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.
摘要翻译： 本发明涉及由式（1）表示的氰基三唑化合物或其盐，其中每个符号在说明书中定义。 该化合物或其盐可以刺激柠檬酸循环活性和/或改善高血糖症，副作用少，安全性优异，因此可用于治疗和/或预防柠檬酸循环活性化和/或预防 高血糖的改善具有预防和/或治疗效果，例如糖尿病，葡萄糖耐量降低，胰岛素抵抗，糖尿病并发症，肥胖症，血脂异常，肝脂肪变性，动脉粥样硬化和/或心血管疾病以及有益于的疾病或病症 从刺激能源开支。
-
9.发明授权
公开(公告)号：EP2753617B1
公开(公告)日：2016-04-13
申请号：EP12766485.2
申请日：2012-09-07
发明人： YAMASHITA, Hiroshi , SAKURAI, Yohji , MIYAMOTO, Motoyuki , NAKAMURA, Yuichi , KURODA, Hideaki , MINOWA, Takuya
IPC分类号： C07D409/12 , A61K31/4704 , A61P25/00
CPC分类号： A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K31/695 , C07D409/12 , C07D409/14
摘要： Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.
-
公开(公告)号：EP2435046B1
公开(公告)日：2013-09-04
申请号：EP10726330.3
申请日：2010-05-27
IPC分类号： C07D491/048 , C07D491/056 , C07D495/04 , C07D519/00 , C07D471/04 , A61K31/519 , A61P25/22 , A61P25/24
CPC分类号： C07D471/04 , A61K31/519 , C07D491/048 , C07D491/056 , C07D495/04 , C07D519/00
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.03 秒)
