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1.发明授权CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED NITROGEN-CONTAINING 5-MEMBERED HETEROCYCLES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR GAMMA 有权甲酰胺或磺酰胺取代的氮含有5元杂环THAN孤儿受体ROR GAMMA调节剂
公开(公告)号：EP2882710B1
公开(公告)日：2016-09-07
申请号：EP13725577.4
申请日：2013-05-29
IPC分类号： C07D207/34 , C07D231/14 , C07D249/10 , C07D401/04 , C07D405/04 , A61K31/40 , A61P29/00
CPC分类号： C07D207/34 , C07D231/14 , C07D249/10 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D491/107 , C07D495/10
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2.发明授权PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORGAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES 有权PYRROLOSULFONAMIDVERBINDUNGEN调制与孤核受体相关RAR孤儿受体γ放射性活度的（ROR-γ，NR1F3）和用于慢性炎症和自身免疫性的治疗
公开(公告)号：EP2697197B1
公开(公告)日：2015-06-03
申请号：EP12714232.1
申请日：2012-04-13
IPC分类号： C07D209/30 , C07D207/36 , C07D401/04 , C07D403/04 , C07D403/10
CPC分类号： C07D209/30 , C07D207/36 , C07D401/04 , C07D403/04 , C07D403/10
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3.发明公开PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORY, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES 审中-公开与CORE受体RAR相关孤儿受体GAMMA-ACTIVITY孤儿PYRROLOCARBOXAMIDE AS调制器（RORY，NR1F3）和慢性炎症性和自身免疫性疾病的治疗
公开(公告)号：EP2800745A1
公开(公告)日：2014-11-12
申请号：EP12795742.1
申请日：2012-12-03
IPC分类号： C07D261/20 , C07D311/96 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D498/20 , C07D207/337 , A61K31/40
CPC分类号： C07D513/10 , C07D207/337 , C07D207/34 , C07D261/20 , C07D311/96 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D471/04 , C07D498/20
摘要： The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administrating these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of Formula (1) and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof.
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4.发明公开NOVEL COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (ROR GAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASE 有权新化合物与孤儿核受体RAR相关孤儿受体γ活性（ROR-GAMMA，NR1F3活性）的调制和用于慢性疾病炎症和自身免疫性于治疗
公开(公告)号：EP2542537A1
公开(公告)日：2013-01-09
申请号：EP11706184.6
申请日：2011-02-28
发明人： KINZEL, Olaf , STEENECK, Christoph , KLEYMANN, Gerald , ALBERS, Michael , HOFFMANN, Thomas , KREMOSER, Claus , PEROVIC-OTTSTADT, Sanja , SCHLÜTER, Thomas
IPC分类号： C07D245/06 , C07D267/22 , C07D413/10 , C07D413/12 , C07D417/12 , A61P29/00 , A61P37/00 , A61K31/395 , C07D281/18 , C07D403/12 , C07D487/04 , C07D498/04
CPC分类号： C07D267/22 , C07D245/06 , C07D281/18 , C07D403/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： The invention provides modulators for the orphan nuclear receptor ROR³ and methods for treating ROR³ mediated diseases by administrating these novel ROR³ modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of formula (1) or (2) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
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公开(公告)号：EP2800745B1
公开(公告)日：2020-02-12
申请号：EP12795742.1
申请日：2012-12-03
IPC分类号： C07D261/20 , C07D311/96 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D498/20 , C07D207/337 , A61K31/40
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6.发明授权NOVEL COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (ROR GAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASE 有权新化合物与孤儿核受体RAR相关孤儿受体γ活性（ROR-GAMMA，NR1F3活性）的调制和用于慢性疾病炎症和自身免疫性于治疗
公开(公告)号：EP2542537B1
公开(公告)日：2014-05-21
申请号：EP11706184.6
申请日：2011-02-28
发明人： KINZEL, Olaf , STEENECK, Christoph , KLEYMANN, Gerald , ALBERS, Michael , HOFFMANN, Thomas , KREMOSER, Claus , PEROVIC-OTTSTADT, Sanja , SCHLÜTER, Thomas
IPC分类号： C07D245/06 , C07D267/22 , C07D413/10 , C07D413/12 , C07D417/12 , A61P29/00 , A61P37/00 , A61K31/395 , C07D281/18 , C07D403/12 , C07D487/04 , C07D498/04
CPC分类号： C07D267/22 , C07D245/06 , C07D281/18 , C07D403/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04
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7.发明公开
公开(公告)号：EP4093739A1
公开(公告)日：2022-11-30
申请号：EP21702195.5
申请日：2021-01-22
发明人： KINZEL, Olaf , STEENECK, Christoph , CZEKANSKA, Marta , PINTO, Sheena , SEKTIOGLU, Ibrahim Murathan , DEUSCHLE, Ulrich
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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8.发明公开CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED NITROGEN-CONTAINING 5-MEMBERED HETEROCYCLES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR GAMMA 有权甲酰胺或磺酰胺取代的氮含有5元杂环THAN孤儿受体ROR GAMMA调节剂
公开(公告)号：EP2882710A1
公开(公告)日：2015-06-17
申请号：EP13725577.4
申请日：2013-05-29
IPC分类号： C07D207/34 , C07D231/14 , C07D249/10 , C07D401/04 , C07D405/04 , A61K31/40 , A61P29/00
CPC分类号： C07D207/34 , C07D231/14 , C07D249/10 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D491/107 , C07D495/10
摘要： The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide containing cyclic compounds of Formula (1) to Formula (5) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.
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公开(公告)号：EP2467366A1
公开(公告)日：2012-06-27
申请号：EP10747171.6
申请日：2010-08-19
IPC分类号： C07D249/06 , C07D261/08 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/4192 , A61K31/42 , A61K31/443 , A61K31/4439 , A61P1/16 , A61P3/10 , A61P35/00
CPC分类号： C07D261/08 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/423 , A61K31/4439 , C07D249/06 , C07D413/04 , C07D413/12 , C07D413/14 , Y02A50/409 , Y02A50/414 , Y02A50/415
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
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10.发明公开CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] 审中-公开CARBOXAMIDOODER SULFONAMIDSUBSTITUIERTE THIAZOLE UNDZUGEHÖRIGEDERIVATE ALS MODULATORENFÜRORPHAN-NUKLEARREZEPTOR ROR？
公开(公告)号：EP2855440A1
公开(公告)日：2015-04-08
申请号：EP13727805.7
申请日：2013-05-29
IPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , A61K31/427 , A61P3/10 , A61P17/06 , A61P19/02 , C07D333/38 , C07D239/28 , C07D413/12 , C07D263/34 , C07D493/08 , C07D493/10 , C07D495/10
CPC分类号： C07D277/56 , C07D239/28 , C07D263/34 , C07D277/36 , C07D277/46 , C07D277/52 , C07D307/68 , C07D333/38 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D453/02 , C07D455/02 , C07D487/08 , C07D491/10 , C07D493/08 , C07D493/10 , C07D495/10 , C07D498/08
摘要： The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1′), (100), (100′), (200) and (200′) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明提供了用于孤儿核受体RORy的调节剂以及通过将这些新型RORY调节剂投予需要其的人或哺乳动物来治疗RORy介导的疾病的方法。 具体地说，本发明提供了含有式（1），（1'），（100），（100'），（200）和（200'）的环状化合物和对映异构体，非对映异构体，互变异构体 氧化物，溶剂化物和药学上可接受的盐。
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