公开(公告)号：EP3819310A1

公开(公告)日：2021-05-12

申请号：EP20197556.2

申请日：2016-10-24

申请人： SANOFI ,  THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： YANG, Zhi-Yong ,  NABEL, Gary J. ,  XU, Ling ,  WEI, Ronnie ,  QIU, Huawei ,  BENINGA, Jochen ,  KRUIP, Jochen ,  RAO, Ercole ,  LEUSCHNER, Wulf Dirk ,  BEIL, Christian ,  LANGE, Christian ,  CONNORS, Mark ,  MASCOLA, John R. ,  KOUP, Richard A. ,  HUANG, Jinghe ,  DORIA-ROSE, Nicole A. ,  ZHOU, Tongqing ,  KWONG, Peter D. ,  KWON, Young Do. ,  PEGU, Amarendra ,  ASOKAN, Mangaiarkarasi

IPC分类号： C07K16/10 ,  A61P31/18 ,  A61K47/68 ,  C07K16/46 ,  A61K39/42

摘要： Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.