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1.发明公开
公开(公告)号：EP3365366A1
公开(公告)日：2018-08-29
申请号：EP16794472.7
申请日：2016-10-24
发明人： YANG, Zhi-Yong , NABEL, Gary, J. , XU, Ling , WEI, Ronnie , QIU, Huawei , BENINGA, Jochen , KRUIP, Jochen , RAO, Ercole , LEUSCHNER, Wulf, Dirk , BEIL, Christian , LANGE, Christian , CONNORS, Mark , MASCOLA, John, R. , KOUP, Richard, A. , HUANG, Jinghe , DORIA-ROSE, Nicole, A. , ZHOU, Tongqing , KWONG, Peter, D. , KWON, Young, Do , PEGU, Amarendra , ASOKAN, Mangaiarkarasi
CPC分类号： A61K47/6881 , A61K39/42 , C07K16/1063 , C07K16/468 , C07K2317/31 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided herein are compositions comprising trispecifie and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, where in a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecifie and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.
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2.发明公开
公开(公告)号：EP3819310A1
公开(公告)日：2021-05-12
申请号：EP20197556.2
申请日：2016-10-24
发明人： YANG, Zhi-Yong , NABEL, Gary J. , XU, Ling , WEI, Ronnie , QIU, Huawei , BENINGA, Jochen , KRUIP, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian , LANGE, Christian , CONNORS, Mark , MASCOLA, John R. , KOUP, Richard A. , HUANG, Jinghe , DORIA-ROSE, Nicole A. , ZHOU, Tongqing , KWONG, Peter D. , KWON, Young Do. , PEGU, Amarendra , ASOKAN, Mangaiarkarasi
摘要： Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.
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3.发明公开
公开(公告)号：EP3812398A3
公开(公告)日：2021-07-21
申请号：EP20170198.4
申请日：2016-01-22
申请人： SANOFI
发明人： ALBRECHT, Jana , BARRIERE, Cédric , BEIL, Christian , BENINGA, Jochen , CARREZ, Chantal , GUERIF, Stéphane , KROLL, Katja , LANGE, Christian , LEMOINE, Cendrine , LEUSCHNER, Wulf-Dirk , RAO, Ercole , SCHNEIDER, Marion , WETZEL, Marie-Cécile , WONEROW, Peter
摘要： The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.
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公开(公告)号：EP3484924A1
公开(公告)日：2019-05-22
申请号：EP17749380.6
申请日：2017-07-17
申请人： Sanofi
发明人： ALBRECHT, Jana , BEIL, Christian , BENINGA, Jochen , KROLL, Katja , LANGE, Christian , LEUSCHNER, Wulf Dirk , RAO, Ercole , SCHNEIDER, Marion , WONEROW, Peter , GUERIF, Stéphane
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
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5.发明授权DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION 有权抗体结合带双可变区相关蛋白及结合区域交叉对准
公开(公告)号：EP2691416B1
公开(公告)日：2016-05-18
申请号：EP12716818.5
申请日：2012-03-28
申请人： SANOFI
发明人： BAURIN, Nicolas , BEIL, Christian , CORVEY, Carsten , LANGE, Christian , LI, Danxi , MIKOL, Vincent , STEINMETZ, Anke , RAO, Ercole
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.
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6.发明公开IMMUNO IMAGING AGENT FOR USE WITH ANTIBODY-DRUG CONJUGATE THERAPY 有权IMMUNKONTRASTMITTELFÜRANTIKÖRPER-WIRKSTOFF-KONJUGAT-THERAPIE
公开(公告)号：EP2953977A1
公开(公告)日：2015-12-16
申请号：EP14717073.2
申请日：2014-02-05
申请人： SANOFI
CPC分类号： C07K16/3092 , C07K2317/24 , C07K2317/35 , C07K2317/56 , C07K2317/626 , C07K2317/64 , C07K2317/92 , C07K2317/94 , C07K2319/21 , G01N2800/52
摘要： The invention relates to a companion diagnostic antibody-like binding protein based on the humanized monoclonal antibody, DS6, to be used as diagnostic tool for
in vivo detection and quantification of the tumor-associated MUCl-sialoglycotope, CA6.摘要翻译： 本发明涉及一种基于人源化单克隆抗体DS6的伴随诊断抗体样结合蛋白，用作用于体内检测和定量肿瘤相关MUCI-唾液酸多糖CA6的诊断工具。
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公开(公告)号：EP4257193A2
公开(公告)日：2023-10-11
申请号：EP23179697.0
申请日：2017-04-13
申请人： Sanofi
发明人： YANG, Zhi-Yong , LANGE, Christian , CORVEY, Carsten , NABEL, Gary J. , WU, Lan , SEUNG, Edward , WEI, Ronnie , BENINGA, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian
IPC分类号： A61P29/00
摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
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8.发明公开
公开(公告)号：EP4039710A3
公开(公告)日：2022-10-19
申请号：EP22152787.2
申请日：2016-01-22
申请人： SANOFI
发明人： ALBRECHT, Jana , BARRIERE, Cédric , BEIL, Christian , BENINGA, Jochen , CARREZ, Chantal , GUERIF, Stéphane , KROLL, Katja , LANGE, Christian , LEMOINE, Cendrine , LEUSCHNER, Wulf-Dirk , RAO, Ercole , SCHNEIDER, Marion , WETZEL, Marie-Cécile , WONEROW, Peter
摘要： The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.
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公开(公告)号：EP3319986A1
公开(公告)日：2018-05-16
申请号：EP16736427.2
申请日：2016-07-06
申请人： SANOFI
发明人： CORVEY, Carsten , STUMP, Heike , KRUIP, Jochen , LANGE, Christian , FOCKEN, Ingo , RAT, Dorothea , STUEDEMANN, Thomas , RASSER, Hans-Falk , SCHAEFER, Juergen , CALANDRA, Bernhard , REY, Astrid , MOUREZ, Michael , FRAISSE, Laurent , ROTHE, Christine , ALLERSDORFER, Andrea , WIEDENMANN, Alexander , HINNER, Marlon , LUNDE, Bradley , JENSEN, Kristian , HÜLSMEYER, Martin
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/50 , C07K2319/70
摘要： The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.
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公开(公告)号：EP2953977B1
公开(公告)日：2017-10-25
申请号：EP14717073.2
申请日：2014-02-05
申请人： SANOFI
CPC分类号： C07K16/3092 , C07K2317/24 , C07K2317/35 , C07K2317/56 , C07K2317/626 , C07K2317/64 , C07K2317/92 , C07K2317/94 , C07K2319/21 , G01N2800/52
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