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1.发明公开
公开(公告)号：EP3819310A1
公开(公告)日：2021-05-12
申请号：EP20197556.2
申请日：2016-10-24
发明人： YANG, Zhi-Yong , NABEL, Gary J. , XU, Ling , WEI, Ronnie , QIU, Huawei , BENINGA, Jochen , KRUIP, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian , LANGE, Christian , CONNORS, Mark , MASCOLA, John R. , KOUP, Richard A. , HUANG, Jinghe , DORIA-ROSE, Nicole A. , ZHOU, Tongqing , KWONG, Peter D. , KWON, Young Do. , PEGU, Amarendra , ASOKAN, Mangaiarkarasi
摘要： Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.
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2.发明公开
公开(公告)号：EP3365366A1
公开(公告)日：2018-08-29
申请号：EP16794472.7
申请日：2016-10-24
发明人： YANG, Zhi-Yong , NABEL, Gary, J. , XU, Ling , WEI, Ronnie , QIU, Huawei , BENINGA, Jochen , KRUIP, Jochen , RAO, Ercole , LEUSCHNER, Wulf, Dirk , BEIL, Christian , LANGE, Christian , CONNORS, Mark , MASCOLA, John, R. , KOUP, Richard, A. , HUANG, Jinghe , DORIA-ROSE, Nicole, A. , ZHOU, Tongqing , KWONG, Peter, D. , KWON, Young, Do , PEGU, Amarendra , ASOKAN, Mangaiarkarasi
CPC分类号： A61K47/6881 , A61K39/42 , C07K16/1063 , C07K16/468 , C07K2317/31 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided herein are compositions comprising trispecifie and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, where in a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecifie and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.
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公开(公告)号：EP3953388A1
公开(公告)日：2022-02-16
申请号：EP20722422.1
申请日：2020-04-08
申请人： SANOFI
发明人： BIRKENFELD, Joerg , NABEL, Gary J. , QIU, Huawei , REGULA, Joerg , SEUNG, Edward , WEI, Ronnie , WU, Lan , XING, Zhen , XU, Ling , PRADES, Catherine , DABDOUBI, Tarik , CAMERON, Béatrice , LEMOINE, Cendrine , YANG, Zhi-Yong
IPC分类号： C07K16/28 , C12N5/0783
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公开(公告)号：EP3583126A1
公开(公告)日：2019-12-25
申请号：EP18711427.7
申请日：2018-02-16
申请人： Sanofi
发明人： SEVIGNY, Leila , BEIL, Christian , BRONDYK, William, H. , CHEN, Yangde , CHENG, Seng, H. , CONNORS, Timothy, D. , DEVAUD, Catherine , HOFFMANN, Dietmar , LANGE, Christian , MAGNAY, Maureen , MAGNAY, Tristan , PRADES, Catherine , RAO, Ercole , WEI, Ronnie , ZHAO, Hongmei , ZHU, Yunxiang
IPC分类号： C07K16/18 , C07K16/28 , A61K39/395 , A61P21/00
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公开(公告)号：EP3443006A2
公开(公告)日：2019-02-20
申请号：EP17732263.3
申请日：2017-04-13
申请人： Sanofi
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公开(公告)号：EP4249068A2
公开(公告)日：2023-09-27
申请号：EP23173927.7
申请日：2018-10-09
申请人： Sanofi
发明人： WU, Lan , PRADES, Catherine , XU, Ling , SEUNG, Edward , WEI, Ronnie , NABEL, Gary , YANG, Zhi-Yong , DABDOUBI, Tarik , CAMERON, Béatrice , LEMOINE, Cendrine
IPC分类号： A61P35/00
摘要： The disclosure provides binding proteins that bind CD38 polypeptides, e.g., human and cynomolgus monkey CD38 polypeptides. For example, the binding proteins can be monospecific, bispecific, or trispecific binding proteins with at least one antigen binding domain that binds a CD38 polypeptide. The disclosure also provides methods for making binding proteins that bind CD38 polypeptides and uses of such binding proteins.
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公开(公告)号：EP3694882A2
公开(公告)日：2020-08-19
申请号：EP18792827.0
申请日：2018-10-09
申请人： Sanofi
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公开(公告)号：EP4257193A3
公开(公告)日：2024-01-24
申请号：EP23179697.0
申请日：2017-04-13
申请人： Sanofi
发明人： YANG, Zhi-Yong , LANGE, Christian , CORVEY, Carsten , NABEL, Gary J. , WU, Lan , SEUNG, Edward , WEI, Ronnie , BENINGA, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian
摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
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公开(公告)号：EP4249068A3
公开(公告)日：2023-11-22
申请号：EP23173927.7
申请日：2018-10-09
申请人： Sanofi
发明人： WU, Lan , PRADES, Catherine , XU, Ling , SEUNG, Edward , WEI, Ronnie , NABEL, Gary , YANG, Zhi-Yong , DABDOUBI, Tarik , CAMERON, Béatrice , LEMOINE, Cendrine
摘要： The disclosure provides binding proteins that bind CD38 polypeptides, e.g., human and cynomolgus monkey CD38 polypeptides. For example, the binding proteins can be monospecific, bispecific, or trispecific binding proteins with at least one antigen binding domain that binds a CD38 polypeptide. The disclosure also provides methods for making binding proteins that bind CD38 polypeptides and uses of such binding proteins.
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公开(公告)号：EP4257193A2
公开(公告)日：2023-10-11
申请号：EP23179697.0
申请日：2017-04-13
申请人： Sanofi
发明人： YANG, Zhi-Yong , LANGE, Christian , CORVEY, Carsten , NABEL, Gary J. , WU, Lan , SEUNG, Edward , WEI, Ronnie , BENINGA, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian
IPC分类号： A61P29/00
摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
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