公开(公告)号：EP4262802A1

公开(公告)日：2023-10-25

申请号：EP21907719.5

申请日：2021-12-15

申请人： Children's Hospital Medical Center ,  The USA, as represented by The Secretary, Department of Health and Human Services ,  Kurome Therapeutics, Inc.

发明人： HOYT, Scott, Bryan ,  THOMAS, Craig, Joseph ,  STARCZYNOWSKI, Daniel, T. ,  SUTTER, Patrick, Joseph ,  TAWA, Gregory, James ,  FINOCCHIO, Chris, James ,  ROSENBAUM, Jan, Susan ,  GRACIA MALDONADO, Gabriel

IPC分类号： A61K31/5025 ,  C07D487/04 ,  C07D401/04 ,  C07D401/14 ,  A61P35/00

公开(公告)号：EP4185243A1

公开(公告)日：2023-05-31

申请号：EP21845838.8

申请日：2021-07-20

申请人： The USA, as represented by The Secretary, Department of Health and Human Services

发明人： LEDERMAN, Robert J. ,  ROGERS, Toby

IPC分类号： A61F2/24

公开(公告)号：EP3688142A1

公开(公告)日：2020-08-05

申请号：EP18782605.2

申请日：2018-09-17

申请人： The USA, as represented by The Secretary, Department of Health and Human Services

发明人： DENIGER, Drew C. ,  ROSENBERG, Steven A. ,  MALEKZADEH, Parisa

IPC分类号： C12N5/0783 ,  C12N5/0784 ,  A61K35/17 ,  A61K39/00 ,  C07K14/47

公开(公告)号：EP2035003A1

公开(公告)日：2009-03-18

申请号：EP07795945.0

申请日：2007-06-08

申请人： The Govt Of The USA, As Represented By The Secretary, Department Of Health And Human Services

发明人： HELLMANN, Kurt ,  GREIG, Nigel, H.

IPC分类号： A61K31/496 ,  A61P25/28 ,  A61P25/16 ,  A61P25/00 ,  A61P43/00

CPC分类号： A61K31/496

摘要： Disclosed are methods of reducing amyloid-β peptide levels in a subject. The method involves administering to the subject a therapeutically effective amount of a bisdioxopiperazine or a pharmaceutically acceptable salt thereof to reduce β-amyloid peptide levels.

公开(公告)号：EP1996615A2

公开(公告)日：2008-12-03

申请号：EP07861245.4

申请日：2007-02-21

申请人： Government of the USA, as Represented by the Secretary, Department of Health and Human Services

发明人： NABEL, Gary J. ,  KIM, Jae Ouk

IPC分类号： C07K14/47 ,  C12N9/20 ,  A61P31/12 ,  A61P31/18 ,  A61K38/46 ,  C12N15/62

CPC分类号： C12N9/20 ,  A61K38/00 ,  C07K14/4726 ,  C07K2319/01 ,  C07K2319/33 ,  Y02A50/385

摘要： The instant invention provides compositions and methods for the treatment of viral infections caused by enveloped viruses comprising phospholipase nucleic acid molecules or polypeptides, or fusion molecules comprising phospholipase molecules or functional fragments thereof.

公开(公告)号：EP4284798A1

公开(公告)日：2023-12-06

申请号：EP22705222.2

申请日：2022-01-26

申请人： The USA, as represented by The Secretary, Department of Health and Human Services

发明人： ZHAO, Xuezhi ,  WANG, Wenjie ,  LOUNTOS, George, Themistoclis ,  KISELEV, Evgeny, Anatolyevich ,  WAUGH, David, Spencer ,  POMMIER, Yves, Georges ,  BURKE, Terrence, Richard, Jr.

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61P35/00 ,  A61K31/437 ,  A61K31/4985

公开(公告)号：EP4069213A1

公开(公告)日：2022-10-12

申请号：EP20825386.4

申请日：2020-12-03

申请人： The USA, as represented by The Secretary, Department of Health and Human Services

发明人： LEVINE, Stewart, J. ,  YAO, Xianglan ,  KALER, Maryann ,  REMALEY, Alan, T. ,  BAROCHIA, Amisha, V.

IPC分类号： A61K31/167 ,  A61K31/192 ,  A61K31/365 ,  A61K31/415 ,  A61K31/42 ,  A61K31/616 ,  A61K31/635 ,  A61K45/06 ,  A61P11/06 ,  G01N33/48

公开(公告)号：EP3823567A1

公开(公告)日：2021-05-26

申请号：EP19756444.6

申请日：2019-07-18

申请人： The USA, as represented by The Secretary, Department of Health and Human Services

发明人： SIEVING, Paul Albert ,  BUSH, Ronald Avery ,  SONG, Hongman ,  WEI, Lisa L. ,  ZENG, Yong ,  WILEY, Henry Ernest

IPC分类号： A61F9/00 ,  A61N1/30 ,  A61N1/32 ,  A61K9/00 ,  A61N1/36 ,  A61K48/00 ,  C12N15/87 ,  A61K9/51

公开(公告)号：EP3365366A1

公开(公告)日：2018-08-29

申请号：EP16794472.7

申请日：2016-10-24

申请人： SANOFI ,  THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： YANG, Zhi-Yong ,  NABEL, Gary, J. ,  XU, Ling ,  WEI, Ronnie ,  QIU, Huawei ,  BENINGA, Jochen ,  KRUIP, Jochen ,  RAO, Ercole ,  LEUSCHNER, Wulf, Dirk ,  BEIL, Christian ,  LANGE, Christian ,  CONNORS, Mark ,  MASCOLA, John, R. ,  KOUP, Richard, A. ,  HUANG, Jinghe ,  DORIA-ROSE, Nicole, A. ,  ZHOU, Tongqing ,  KWONG, Peter, D. ,  KWON, Young, Do ,  PEGU, Amarendra ,  ASOKAN, Mangaiarkarasi

IPC分类号： C07K16/10 ,  A61K39/42

CPC分类号： A61K47/6881 ,  A61K39/42 ,  C07K16/1063 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Provided herein are compositions comprising trispecifie and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, where in a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecifie and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.

公开(公告)号：EP2200639B1

公开(公告)日：2016-03-30

申请号：EP08870520.7

申请日：2008-09-24

申请人： Government of the USA, as Represented by the Secretary, Department of Health and Human Services

发明人： BERZOFSKY, Jay, A. ,  ZHU, Qing ,  BELYAKOV, Igor

IPC分类号： A61K39/39 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K39/21 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/57 ,  C12N7/00 ,  C12N2740/16034 ,  Y02A50/394

摘要： The present invention provides immunostimulatory combinations of TLR ligands and therapeutic and/or prophylactic methods that include administering an immunostimulatory combination to a subject. In general, the immunostimulatory combinations described herein can provide an increased immune response compared to other immunostimulatory combinations and/or compositions.