公开(公告)号：EP3819310A1

公开(公告)日：2021-05-12

申请号：EP20197556.2

申请日：2016-10-24

申请人： SANOFI ,  THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： YANG, Zhi-Yong ,  NABEL, Gary J. ,  XU, Ling ,  WEI, Ronnie ,  QIU, Huawei ,  BENINGA, Jochen ,  KRUIP, Jochen ,  RAO, Ercole ,  LEUSCHNER, Wulf Dirk ,  BEIL, Christian ,  LANGE, Christian ,  CONNORS, Mark ,  MASCOLA, John R. ,  KOUP, Richard A. ,  HUANG, Jinghe ,  DORIA-ROSE, Nicole A. ,  ZHOU, Tongqing ,  KWONG, Peter D. ,  KWON, Young Do. ,  PEGU, Amarendra ,  ASOKAN, Mangaiarkarasi

IPC分类号： C07K16/10 ,  A61P31/18 ,  A61K47/68 ,  C07K16/46 ,  A61K39/42

摘要： Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.

公开(公告)号：EP3365366A1

公开(公告)日：2018-08-29

申请号：EP16794472.7

申请日：2016-10-24

申请人： SANOFI ,  THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： YANG, Zhi-Yong ,  NABEL, Gary, J. ,  XU, Ling ,  WEI, Ronnie ,  QIU, Huawei ,  BENINGA, Jochen ,  KRUIP, Jochen ,  RAO, Ercole ,  LEUSCHNER, Wulf, Dirk ,  BEIL, Christian ,  LANGE, Christian ,  CONNORS, Mark ,  MASCOLA, John, R. ,  KOUP, Richard, A. ,  HUANG, Jinghe ,  DORIA-ROSE, Nicole, A. ,  ZHOU, Tongqing ,  KWONG, Peter, D. ,  KWON, Young, Do ,  PEGU, Amarendra ,  ASOKAN, Mangaiarkarasi

IPC分类号： C07K16/10 ,  A61K39/42

CPC分类号： A61K47/6881 ,  A61K39/42 ,  C07K16/1063 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Provided herein are compositions comprising trispecifie and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, where in a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecifie and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.

公开(公告)号：EP3812398A3

公开(公告)日：2021-07-21

申请号：EP20170198.4

申请日：2016-01-22

申请人： SANOFI

发明人： ALBRECHT, Jana ,  BARRIERE, Cédric ,  BEIL, Christian ,  BENINGA, Jochen ,  CARREZ, Chantal ,  GUERIF, Stéphane ,  KROLL, Katja ,  LANGE, Christian ,  LEMOINE, Cendrine ,  LEUSCHNER, Wulf-Dirk ,  RAO, Ercole ,  SCHNEIDER, Marion ,  WETZEL, Marie-Cécile ,  WONEROW, Peter

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  A61P35/02

摘要： The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.

公开(公告)号：EP3484924A1

公开(公告)日：2019-05-22

申请号：EP17749380.6

申请日：2017-07-17

申请人： Sanofi

发明人： ALBRECHT, Jana ,  BEIL, Christian ,  BENINGA, Jochen ,  KROLL, Katja ,  LANGE, Christian ,  LEUSCHNER, Wulf Dirk ,  RAO, Ercole ,  SCHNEIDER, Marion ,  WONEROW, Peter ,  GUERIF, Stéphane

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K39/00

公开(公告)号：EP2691416B1

公开(公告)日：2016-05-18

申请号：EP12716818.5

申请日：2012-03-28

申请人： SANOFI

发明人： BAURIN, Nicolas ,  BEIL, Christian ,  CORVEY, Carsten ,  LANGE, Christian ,  LI, Danxi ,  MIKOL, Vincent ,  STEINMETZ, Anke ,  RAO, Ercole

IPC分类号： C07K16/00 ,  C07K16/24 ,  C07K16/28 ,  C07K16/32 ,  C07K16/46

CPC分类号： C07K16/46 ,  C07K16/00 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/247 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/32 ,  C07K16/461 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2318/00

摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.

公开(公告)号：EP4257193A2

公开(公告)日：2023-10-11

申请号：EP23179697.0

申请日：2017-04-13

申请人： Sanofi

发明人： YANG, Zhi-Yong ,  LANGE, Christian ,  CORVEY, Carsten ,  NABEL, Gary J. ,  WU, Lan ,  SEUNG, Edward ,  WEI, Ronnie ,  BENINGA, Jochen ,  RAO, Ercole ,  LEUSCHNER, Wulf Dirk ,  BEIL, Christian

IPC分类号： A61P29/00

摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

公开(公告)号：EP4039710A3

公开(公告)日：2022-10-19

申请号：EP22152787.2

申请日：2016-01-22

申请人： SANOFI

发明人： ALBRECHT, Jana ,  BARRIERE, Cédric ,  BEIL, Christian ,  BENINGA, Jochen ,  CARREZ, Chantal ,  GUERIF, Stéphane ,  KROLL, Katja ,  LANGE, Christian ,  LEMOINE, Cendrine ,  LEUSCHNER, Wulf-Dirk ,  RAO, Ercole ,  SCHNEIDER, Marion ,  WETZEL, Marie-Cécile ,  WONEROW, Peter

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  A61P35/02

摘要： The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.

公开(公告)号：EP2513147B1

公开(公告)日：2016-07-20

申请号：EP10813028.7

申请日：2010-12-17

申请人： SANOFI

发明人： BAURIN, Nicolas ,  BLANCHE, Francis ,  CAMERON, Béatrice ,  CORVEY, Carsten ,  DABDOUBI, Tarik ,  ENGEL, Christian ,  FLORIAN, Peter ,  FOCKEN, Ingo ,  KROLL, Katja ,  KRUIP, Jochen ,  LANGE, Christian ,  LANGER, Thomas ,  LORENZ, Martin ,  MIKOL, Vincent ,  RAO, Ercole ,  WONEROW, Peter

IPC分类号： C07K16/28 ,  A61K39/00 ,  C07K1/107

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K1/1075 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP2525807B1

公开(公告)日：2014-11-12

申请号：EP11700669.2

申请日：2011-01-21

申请人： SANOFI

发明人： SOMMERFELD, Mark ,  SCHAEFER, Hans-Ludwig ,  BOSCHEINEN, Oliver ,  HABERMANN, Paul ,  RAO, Ercole ,  DREYER, Matthias

IPC分类号： A61K38/18 ,  A61K38/26 ,  A61P3/00

CPC分类号： A61K38/1825 ,  A61K38/26 ,  A61K45/06 ,  C07K14/50 ,  C07K2319/30 ,  A61K2300/00

公开(公告)号：EP2205640B1

公开(公告)日：2013-11-20

申请号：EP08839958.9

申请日：2008-10-14

申请人： SANOFI

发明人： RAO, Ercole ,  MIKOL, Vincent ,  LI, Danxi ,  KRUIP, Jochen ,  DAVISON, Matthew

IPC分类号： C07K16/46 ,  C07K16/24 ,  A61K39/395 ,  A61P35/00 ,  A61P37/08 ,  A61P11/06

CPC分类号： C07K16/468 ,  C07K16/244 ,  C07K16/247 ,  C07K2317/31 ,  C07K2317/64 ,  C07K2317/76

摘要： The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.

摘要翻译： 本发明涉及多价双特异性抗体形式，其包含作为恒定重链的第一多肽和作为恒定轻链的第二多肽，其中所述第一多肽连接至重链的两个或更多个可变结构域，并且 第二多肽连接到轻链的两个或多个可变结构域。 本发明的优选实施方案是指四价双特异性串联免疫球蛋白（TBTI）。 本发明的多价双特异性抗体类似并保持免疫球蛋白分子的稳定性特征，在两个不同的多肽上表达重链和轻链，并结合恒定的重区域和恒定的光区域，以稳定可变重的 和可变光域并强制相应的VHNL的正确配对。 本发明还涉及这种多价双特异性抗体的用途。