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    TRICYCLIC HETEROCYCLIC DERIVATIVE HAVING HIV REPLICATION-INHIBITING EFFECT
    2.
    发明公开
    TRICYCLIC HETEROCYCLIC DERIVATIVE HAVING HIV REPLICATION-INHIBITING EFFECT 审中-公开
    干细胞移植治疗麻疹艾滋病毒感染病毒WIRKUNG

    公开(公告)号：EP3144311A1

    公开(公告)日：2017-03-22

    申请号：EP15793640.2

    申请日：2015-05-15

    申请人： Shionogi & Co., Ltd.

    发明人： KAWASUJI, Takashi ,  TANIYAMA, Daisuke ,  SUGIYAMA, Shuichi ,  TAMURA, Yoshinori

    IPC分类号： C07D487/06 ,  A61K31/519 ,  A61K31/5513 ,  A61K31/554 ,  A61P31/12 ,  A61P31/18 ,  C07D513/06

    CPC分类号： C07D513/06 ,  A61K31/519 ,  A61K31/5513 ,  A61K31/554 ,  C07D471/06 ,  C07D471/16 ,  C07D487/06 ,  Y02P20/55

    摘要： The present invention provides the following compound having anti-HIV activity of formula:

    wherein, A 1 is C, CR 1A or N;
    A 2 is C, CR 2A , or N;
    A 3 is CR 3A , CR 3A R 3B , N, NR 3c O, S, SO, or SO 2 ;
    A 4 is CR 4A , CR 4A R 4B , N, NR 4C O, S, SO, or SO2;
    A 5 is C, CR 5A , or N;
    T 1 ring is substituted or unsubstituted monocyclic carbocycle or substituted or unsubstituted monocyclic heterocycle;
    R 1 is halogen, cyano, nitro or -X 1 -R 11 ;
    R 2 is substituted or unsubstituted alkyl and the like;
    n is 1 or 2;
    R 3 is hydrogen, substituted or unsubstituted aromatic varbocyclyl;
    R 4 is hydrogen or a carboxy protecting group;
    the other symbols are as specified in the description.

    摘要翻译： 本发明提供具有下式的抗HIV活性的下列化合物：其中A 1为C，CR 1A或N; A 2为C，CR 2A或N; A 3为CR 3A，CR 3A R 3B，N，NR 3c O，S，SO或SO 2; A 4是CR 4A，CR 4A R 4B，N，NR 4C O，S，SO或SO 2; A 5为C，CR 5A或N; T 1环是取代或未取代的单环碳环或取代或未取代的单环杂环; R 1是卤素，氰基，硝基或-X 1 -R 11; R 2是取代或未取代的烷基等; n为1或2; R 3是氢，取代或未取代的芳族杂环基; R 4是氢或羧基保护基; 其他符号在说明书中指定。