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公开(公告)号：EP4186915A1
公开(公告)日：2023-05-31
申请号：EP21841411.8
申请日：2021-07-15
申请人： Sichuan University , Academy of Military Medical Sciences , Chengdu Aupone Pharmaceutical Co., Ltd.
发明人： QIN, Yong , ZHONG, Wu , XUE, Fei , LIU, Xiaoyu , WANG, Yu , ZHOU, Xiaohan , LIU, Bo , WANG, Ke , YANG, Likai , ZHOU, Ruijie , XIAO, Yaxin , XUE, Fanglin , ZHANG, Minjie , SONG, Hao , ZHENG, Zhibing , LI, Song
摘要： Disclosed is a method for preparing a C-nucleoside compound represented by Formula (III) or salt thereof. The present method has a high reaction yield, is simple to operate, uses a single metal reagent, has stable reaction temperature conditions, does not require frequent changes to the reaction system during the operation process, is suitable for scale-up synthesis, is suitable for large-scale production of Remdesivir, and has low costs.
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2.发明公开
公开(公告)号：EP4183792A1
公开(公告)日：2023-05-24
申请号：EP20944871.1
申请日：2020-07-14
发明人： LIU, Xiaoyu , QIN, Yong , ZHONG, Wu , CAO, Ruiyuan , HE, Huan , ZHENG, Zhibing , LI, Song
摘要： The invention relates to a compound represented by general Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable hydrate thereof or pharmaceutically acceptable solvate thereof, and the invention also relates to a pharmaceutical composition comprising the compound, and a preparation method for the compound and a use of the compound.
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公开(公告)号：EP4190785A1
公开(公告)日：2023-06-07
申请号：EP21850321.7
申请日：2021-07-22
发明人： QIN, Yong , ZHONG, Wu , XUE, Fei , ZHANG, Minjie , FAN, Shiyong , ZHENG, Zhibing , LI, Song
IPC分类号： C07D487/04
摘要： The present invention relates to the technical field of chemical drug synthesis, and specifically relates to a method for preparing a compound as shown in formula I, comprising: treating the compound as shown in formula VII with an acid to generate the compound as shown in formula I. The method has few synthetic process steps, raw materials which is stable and is easy to prepare, a reaction process which is easy to control, and a high overall yield and purity, and is suitable for industrial preparation.
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公开(公告)号：EP4205739A1
公开(公告)日：2023-07-05
申请号：EP21845739.8
申请日：2021-07-22
发明人： CAO, Ruiyuan , WANG, Manli , LI, Wei , ZHAO, Lei , YANG, Jingjing , LI, Yuexiang , FAN, Shiyong , ZHOU, Xinbo , XIAO, Dian , HU, Zhihong , LI, Song , ZHONG, Wu
IPC分类号： A61K31/366 , A61K31/357 , A61K31/541 , A61K31/365 , A61K31/19 , A61K31/137 , A61K9/00 , A61P31/14 , A61P11/00
摘要： The present invention relates to an application of an artemisinin compound in treatment of coronavirus infection. Specifically, the present invention provides an application of the compound, and a stereoisomer, a pharmaceutically acceptable salt, a solvate or a hydrate thereof in preparation of medicines. The medicines are used for treating diseases or infection caused by coronavirus (preferably SARS-CoV-2), and the compound is selected from one or more of artemisinin, arteether, artemether, artemisia ketone, dihydroartemisinin, artesunate, arteannuin B, and artemisinic acid.
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公开(公告)号：EP3960741A1
公开(公告)日：2022-03-02
申请号：EP20795447.0
申请日：2020-04-24
发明人： ZHONG, Wu , HAO, Tianlong , CAO, Ruiyuan , CHENG, Tong , LI, Yuexiang , FAN, Shiyong , LI, Wei , WANG, Shixu , XIA, Ningshao , LI, Song
IPC分类号： C07D471/04 , C07D498/04 , C07D519/00 , A61K31/47 , A61K31/4725 , A61K31/4745 , A61P31/12 , A61P1/00
摘要： Provided are quinoline derivative compounds of Formulae (I), (II) and (III) with an inhibitory effect on mTOR and applications of their pharmaceutically acceptable salts, their stereoisomers, their hydrates or their solvates in preparation of medicine for preventing and/or treating diseases caused by enteroviruses.
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6.发明公开
公开(公告)号：EP3845251A1
公开(公告)日：2021-07-07
申请号：EP19853328.3
申请日：2019-08-28
发明人： ZHOU, Xinbo , WANG, Yanming , LI, Song , ZHONG, Wu , FAN, Shiyong , XIAO, Dian , XIAO, Junhai , ZHENG, Zhibing , LI, Xingzhou , XIE, Yunde , CAO, Ruiyuan , WANG, Xiaokui
摘要： The present application relates to a linker containing arylnitro, an antibody-drug conjugate the linker and use of the linker, as well as a pharmaceutical composition comprising the antibody-drug conjugate and use of the antibody-drug conjugate for treatment and/or prevention of a disease.
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公开(公告)号：EP3485886A1
公开(公告)日：2019-05-22
申请号：EP17826907.2
申请日：2017-07-04
发明人： ZHONG, Wu , YANG, Meiyan , GONG, Wei , WANG, Yuli , GAO, Chunsheng , ZHOU, Xinbo , LI, Song
IPC分类号： A61K31/403 , A61K47/18 , A61K9/08 , A61P31/20
摘要： The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.
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公开(公告)号：EP3381910A1
公开(公告)日：2018-10-03
申请号：EP16867999.1
申请日：2016-11-24
发明人： LI, Song , XIAO, Junhai , XU, Libao , CAO, Ruiyuan , CAO, Fangyuan , WANG, Hongliang , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui
IPC分类号： C07D277/52 , A61K31/426 , A61P31/12 , A61P31/16 , A61P11/04 , A61P1/16 , A61P31/18 , A61P31/14
CPC分类号： A61K31/426 , C07D277/52 , Y02A50/465
摘要： The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection.
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公开(公告)号：EP3327010A1
公开(公告)日：2018-05-30
申请号：EP16817233.6
申请日：2016-06-28
发明人： LI, Song , XIAO, Junhai , LYU, Boqun , WANG, Hongqiang , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHOU, Xinbo , LI, Xingzhou , WANG, Xiaokui
摘要： The invention belongs to the technical field of medicines. In particular, the invention relates to a thiazideamide derivative compound or a pharmaceutically acceptable salt or solvate thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt or solvate thereof, a method for preparing the compound or a pharmaceutically acceptable salt or solvate thereof, and a use of the compound or a pharmaceutically acceptable salt or solvate thereof. For example, the compound or a pharmaceutically acceptable salt or solvate thereof according to the invention can be used to prevent and/or treat a neurodegenerative disease or a neuropathic disease caused by a physical trauma or a related disease.
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10.发明授权
公开(公告)号：EP3006432B1
公开(公告)日：2017-11-15
申请号：EP14804849.9
申请日：2014-05-28
发明人： LI, Song , XIAO, Junhai , ZHANG, Xian , ZHONG, Wu , ZHENG, Zhibing , WANG, Lili , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui
IPC分类号： C07D303/48 , C07D301/00 , C07D417/12 , C07D417/14 , A61K31/336 , A61K31/427 , A61K31/428 , A61P31/14 , A61P31/16
CPC分类号： C07D417/12 , C07D303/48 , C07D417/14
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