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公开(公告)号：EP3660036A1
公开(公告)日：2020-06-03
申请号：EP18838960.5
申请日：2018-07-25
申请人： Spiber Inc. , Riken
发明人： MORITA Keisuke , ABE Yunosuke , MAEKAWA Takehisa , KOTAKA Koichi , SUGAHARA Junichi , NUMATA Keiji
摘要： The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A) n motif-REP] m or Formula 2: [(A) n motif-REP] m -(A) n motif, in which the domain sequence has an amino acid sequence with a reduced content of a glutamine residue equivalent to an amino acid in which one or a plurality of glutamine residues in REP are deleted or substituted with other amino acid residues, as compared with a naturally occurring fibroin. [In Formula 1 and Formula 2, (A) n motif represents an amino acid sequence consisting of 4 to 27 amino acid residues, and the number of alanine residues with respect to the total number of amino acid residues in the (A) n motif is 80% or more. REP represents an amino acid sequence consisting of 10 to 200 amino acid residues, m represents an integer of 10 to 300. A plurality of (A) n motifs may be the same amino acid sequence or different amino acid sequences.]
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公开(公告)号：EP4036291A1
公开(公告)日：2022-08-03
申请号：EP20868406.8
申请日：2020-09-25
申请人： Spiber Inc.
发明人： ISHII Hideto , IGARASHI Mizuki , ADACHI Tatsuki , ABE Yunosuke
IPC分类号： D02J1/22 , C07K14/435 , C12N15/12 , D01F4/02
摘要： An object of the present invention is to provide a method capable of producing a protein fiber in which shrinkage at the time of first contact with moisture after production is more reliably suppressed and generation of crimp is also suppressed. A method for producing a protein fiber according to the present invention includes: a pre-shrinking step of shrinking a protein fibril in a relaxed state after drawing and before being wound; a winding step of winding the protein fibril subjected to the pre-shrinking step to obtain a wound product; and a post-shrinking step of shrinking the protein fibril subjected to the winding step in a relaxed state.
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公开(公告)号：EP3922763A1
公开(公告)日：2021-12-15
申请号：EP20753263.1
申请日：2020-02-07
申请人： Spiber Inc.
发明人： ANDO Hirotada , ISHII Hideto , KOTAKA Koichi , SATO Ryoko , KANO Hiroshi , KOBAYASHI Jun , SATO Akito , ABE Yunosuke
IPC分类号： D01F4/00 , D01F4/02 , C07K14/435 , C12N15/12
摘要： An object of the present invention is to provide a method for producing an artificial structural protein fiber having a small diameter and having a stress equal to or higher than that of the related art. A method for producing an artificial structural protein fiber according to the present invention is a method for producing an artificial structural protein fiber by a wet spinning method, the method including a coagulation step of discharging a spinning dope containing an artificial structural protein and an organic solvent from a spinneret into a coagulation liquid to coagulate the artificial structural protein, wherein a bath draft in the coagulation step is more than 0.4 and 20 or less.
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公开(公告)号：EP3919658A1
公开(公告)日：2021-12-08
申请号：EP20748244.9
申请日：2020-01-30
发明人： SEKI Masatoshi , TAKAHASHI Hideki , ITO Ren , ABE Yunosuke
摘要： Disclosed is a fiber for artificial hairs that is given a predetermined shape, the fiber being formed from a synthetic fibroin fiber containing a modified fibroin, and the fiber expanding when placed in a wet state and contracting when dried from a wet state. Also disclosed is a method for producing a fiber for artificial hairs that is given a predetermined shape, the method including retaining a fibroin fiber containing a modified fibroin in a state conforming to a predetermined shape. A wetted fibroin fiber may also be heated while being retained in a state conforming to a predetermined shape.
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公开(公告)号：EP4039858A1
公开(公告)日：2022-08-10
申请号：EP20870804.0
申请日：2020-09-28
申请人： Spiber Inc.
发明人： TAKAHASHI Kentaro , IKEDA Atsushi , KAGATA Hideki , ABE Yunosuke , SAKATA Kazuki
IPC分类号： D01F4/02 , C07K14/435 , C12N15/12 , D06M11/00
摘要： An object of the present invention is to provide a method for advantageously producing a protein molded article which can solve a problem caused by esterification of a hydroxyl group contained in a protein while maintaining a sufficient strength. A method for producing a protein molded article according to the present invention includes a step of bringing a raw material molded article containing a protein in which a hydroxyl group is esterified into contact with an acidic or basic medium in a state of applying a tensile force, thus hydrolyzing an ester group.
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公开(公告)号：EP3922764A1
公开(公告)日：2021-12-15
申请号：EP20752918.1
申请日：2020-02-07
申请人： Spiber Inc.
发明人： ABE Yunosuke , ISHII Hideto , SATO Ryoko , SATO Akito , ANDO Hirotada , KANO Hiroshi , KOTAKA Koichi , KOBAYASHI Jun
IPC分类号： D01F4/02 , A61L17/08 , A61L27/22 , C07K14/435
摘要： An object of the present invention is to provide a method for producing a modified fibroin multifilament excellent in productivity and a multifilament produced by the same. The multifilament of the present invention contains modified fibroin, in which the multifilament has 100 or more constituent single yarns, a coefficient of variation in elastic modulus is 15% or less, a coefficient of variation in strength is 15% or less, and a coefficient of variation in elongation is less than 33%.
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公开(公告)号：EP3800286A1
公开(公告)日：2021-04-07
申请号：EP19782354.5
申请日：2019-04-03
发明人： IGARASHI Takumi , IKEDA Atsushi , ABE Yunosuke , HARADA Seiji
摘要： The present invention relates to a high-shrinkage artificial fibroin spun yarn which is a shrunk artificial fibroin spun yarn including a modified fibroin and having a shrinkage rate of greater than 1% defined by the following Formula I: Shrinkage rate = 1 − length of shrunk artificial fibroin spun yarn / length of artificial fibroin spun yarn after spinning and before contact with water × 100 %
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8.发明公开
公开(公告)号：EP3626824A1
公开(公告)日：2020-03-25
申请号：EP18797659.2
申请日：2018-05-09
发明人： ABE Ayumi , MORITA Keisuke , KURACHI Kenji , ABE Yunosuke
IPC分类号： C12N15/12 , C07K14/435 , C08L89/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , D01F4/00
摘要： The present invention relates to a polypeptide solution in which polypeptide including an amino acid sequence derived from type I keratin that belongs to Cluster Ia is dissolved in a solvent including a formic acid or a solvent including an aprotic polar agent having a dipole moment of 3.0 D or more and an inorganic salt.
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