公开(公告)号：EP1780276A4

公开(公告)日：2008-04-23

申请号：EP05780291

申请日：2005-08-03

申请人： RIKEN ,  TAKEDA PHARMACEUTICAL

发明人： IKEGAWA SHIRO ,  KIZAWA HIDEKI ,  MOTOTANI HIDEYUKI

IPC分类号： C12N15/12 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P19/02 ,  A61P19/08 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50

CPC分类号： A61K38/1709 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4725 ,  C07K14/4728 ,  C07K16/28 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N2800/102 ,  G01N2800/105 ,  G01N2800/108

摘要： It is intended to provide a method of preventing and treating bone/joint diseases by controlling the expression or activity of calmodulin; a method of preventing and treating bone/joint diseases by controlling the expression or activity of asporin; a method of diagnosing genetic sensitivity to bone/joint diseases by detecting a polymorphism in CALM1 gene and/or asporin gene; and so on.

公开(公告)号：EP1479768A4

公开(公告)日：2006-02-01

申请号：EP03705107

申请日：2003-02-13

申请人： TAKEDA PHARMACEUTICAL

发明人： HINUMA SHUJI ,  HOSOYA MASAKI ,  ITO YASUAKI ,  KOBAYASHI MAKOTO ,  TANAKA HIDEYUKI ,  OKUBO SHOICHI ,  FUJII RYO ,  KIZAWA HIDEKI ,  KAWAMATA YUJI ,  OGI KAZUHIRO ,  HARADA MASATAKA ,  FUKUSUMI SHOJI

IPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P25/00 ,  A61P35/00 ,  C07K16/28

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/28 ,  C07K2319/60 ,  G01N2333/726 ,  G01N2500/00

摘要： By using (1) a G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 or its salt and (2) a fatty aid or an eicosanoid, it is possible to efficiently screen a compound, which is capable of changing the binding properties of the above receptor protein or its salt to the fatty acid or the eicosanoid, or its salt.